Cerebral sinus venous thrombosis in infants after surgery for congenital heart disease
To determine the prevalence of and risk factors for cerebral sinus venous thrombosis (CSVT) in neonates undergoing congenital heart disease (CHD) repair. Neonates who had CHD repair with cardiopulmonary bypass and a post-operative brain magnetic resonance image (MRI) between 2013 and 2019 at a singl...
Gespeichert in:
| Veröffentlicht in: | The Journal of pediatrics 2022-09, Vol.248, p.59-65.e3 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 65.e3 |
|---|---|
| container_issue | |
| container_start_page | 59 |
| container_title | The Journal of pediatrics |
| container_volume | 248 |
| creator | Harrar, Dana B. Goss, Margaret Donofrio, Mary T. Murnick, Jonathan Reitz, Justus G. Zhang, Anqing Diab, Yaser Meldau, Jennifer Sinha, Pranava Yerebakan, Can Carpenter, Jessica L. |
| description | To determine the prevalence of and risk factors for cerebral sinus venous thrombosis (CSVT) in neonates undergoing congenital heart disease (CHD) repair.
Neonates who had CHD repair with cardiopulmonary bypass and a post-operative brain magnetic resonance image (MRI) between 2013 and 2019 at a single tertiary-care center were identified from institutional databases. Demographic, clinical, and surgical data were abstracted from these databases and from the medical record; 278 neonates with CHD had CPB, 184 of whom had a post-operative brain MRI.
Eight (4.3%) patients had a CSVT. Transposition of the great arteries with intact ventricular septum (D-TGA-IVS) (p |
| doi_str_mv | 10.1016/j.jpeds.2022.05.056 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2674002915</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022347622005303</els_id><sourcerecordid>2674002915</sourcerecordid><originalsourceid>FETCH-LOGICAL-c359t-2a394425915024c3a0207960de8225d66e90a9191b5d15476c289935b9c8d0763</originalsourceid><addsrcrecordid>eNp9kM1LxDAQxYMoun78BYL06KXrJGnS5uBBFr9A8KJeQ5pMNctuu2a6gv-9WVc9Cg_mMG_m8X6MnXKYcuD6Yj6drzDQVIAQU1BZeodNOJi61I2Uu2wCeVPKqtYH7JBoDgCmAthnB1JpXVdVM2EvM0zYJrcoKPZrKj6wH_IY39KwbAeKVMQ-q3P9SIXrRkwFrdMrps-iG1Lhh_4V-zjm-zd0aSxCJHSEx2yvcwvCk595xJ5vrp9md-XD4-397Oqh9FKZsRROmqoSynAFovLSgYDaaAjYCKGC1mjAGW54qwJXuYgXjTFStcY3AWotj9j59u8qDe9rpNEuI3lcLFyPuYcVuWamkP9nq9xafRqIEnZ2leLSpU_LwW6A2rn9Bmo3QC2orE3A2U_Aul1i-Lv5JZgNl1sD5pofEZMlH7H3GGJCP9owxH8DvgBk_och</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2674002915</pqid></control><display><type>article</type><title>Cerebral sinus venous thrombosis in infants after surgery for congenital heart disease</title><source>Elsevier ScienceDirect Journals</source><creator>Harrar, Dana B. ; Goss, Margaret ; Donofrio, Mary T. ; Murnick, Jonathan ; Reitz, Justus G. ; Zhang, Anqing ; Diab, Yaser ; Meldau, Jennifer ; Sinha, Pranava ; Yerebakan, Can ; Carpenter, Jessica L.</creator><creatorcontrib>Harrar, Dana B. ; Goss, Margaret ; Donofrio, Mary T. ; Murnick, Jonathan ; Reitz, Justus G. ; Zhang, Anqing ; Diab, Yaser ; Meldau, Jennifer ; Sinha, Pranava ; Yerebakan, Can ; Carpenter, Jessica L.</creatorcontrib><description>To determine the prevalence of and risk factors for cerebral sinus venous thrombosis (CSVT) in neonates undergoing congenital heart disease (CHD) repair.
Neonates who had CHD repair with cardiopulmonary bypass and a post-operative brain magnetic resonance image (MRI) between 2013 and 2019 at a single tertiary-care center were identified from institutional databases. Demographic, clinical, and surgical data were abstracted from these databases and from the medical record; 278 neonates with CHD had CPB, 184 of whom had a post-operative brain MRI.
Eight (4.3%) patients had a CSVT. Transposition of the great arteries with intact ventricular septum (D-TGA-IVS) (p<0.01) and interrupted aortic arch (IAA) (p=0.02) were associated with an increased risk for CSVT. Other risk factors for CSVT included cross-clamp time (98 minutes [interquartile range (IQR) 77.5-120] v. 67 minutes [IQR 44-102], p=0.03), units of platelets (3.63 [IQR 3-4] v. 2.17 [IQR 1-4], p<0.01) and packed red blood cells (0.81 [IQR 0.25-1] v. 1.21 [IQR 1-1], p=0.03) transfused intra-operatively, and time between surgery and MRI (10 days [IQR 7-12.5] v. 20 days [IQR 12-35], p<0.01). Five patients (62.5%) were treated with anticoagulation. All patients had complete or partial resolution of their CSVT, regardless of treatment.
Brain MRI after CPB in neonates revealed a low prevalence of CSVT (4.3%). Further studies are needed to establish best practices for surveillance, prevention, and treatment of CSVT in this population.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/j.jpeds.2022.05.056</identifier><identifier>PMID: 35667448</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Cardiac surgery ; magnetic resonance imaging ; magnetic resonance venography</subject><ispartof>The Journal of pediatrics, 2022-09, Vol.248, p.59-65.e3</ispartof><rights>2022 Elsevier Inc.</rights><rights>Copyright © 2022 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-2a394425915024c3a0207960de8225d66e90a9191b5d15476c289935b9c8d0763</citedby><cites>FETCH-LOGICAL-c359t-2a394425915024c3a0207960de8225d66e90a9191b5d15476c289935b9c8d0763</cites><orcidid>0000-0001-6382-8479</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022347622005303$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35667448$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harrar, Dana B.</creatorcontrib><creatorcontrib>Goss, Margaret</creatorcontrib><creatorcontrib>Donofrio, Mary T.</creatorcontrib><creatorcontrib>Murnick, Jonathan</creatorcontrib><creatorcontrib>Reitz, Justus G.</creatorcontrib><creatorcontrib>Zhang, Anqing</creatorcontrib><creatorcontrib>Diab, Yaser</creatorcontrib><creatorcontrib>Meldau, Jennifer</creatorcontrib><creatorcontrib>Sinha, Pranava</creatorcontrib><creatorcontrib>Yerebakan, Can</creatorcontrib><creatorcontrib>Carpenter, Jessica L.</creatorcontrib><title>Cerebral sinus venous thrombosis in infants after surgery for congenital heart disease</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>To determine the prevalence of and risk factors for cerebral sinus venous thrombosis (CSVT) in neonates undergoing congenital heart disease (CHD) repair.
Neonates who had CHD repair with cardiopulmonary bypass and a post-operative brain magnetic resonance image (MRI) between 2013 and 2019 at a single tertiary-care center were identified from institutional databases. Demographic, clinical, and surgical data were abstracted from these databases and from the medical record; 278 neonates with CHD had CPB, 184 of whom had a post-operative brain MRI.
Eight (4.3%) patients had a CSVT. Transposition of the great arteries with intact ventricular septum (D-TGA-IVS) (p<0.01) and interrupted aortic arch (IAA) (p=0.02) were associated with an increased risk for CSVT. Other risk factors for CSVT included cross-clamp time (98 minutes [interquartile range (IQR) 77.5-120] v. 67 minutes [IQR 44-102], p=0.03), units of platelets (3.63 [IQR 3-4] v. 2.17 [IQR 1-4], p<0.01) and packed red blood cells (0.81 [IQR 0.25-1] v. 1.21 [IQR 1-1], p=0.03) transfused intra-operatively, and time between surgery and MRI (10 days [IQR 7-12.5] v. 20 days [IQR 12-35], p<0.01). Five patients (62.5%) were treated with anticoagulation. All patients had complete or partial resolution of their CSVT, regardless of treatment.
Brain MRI after CPB in neonates revealed a low prevalence of CSVT (4.3%). Further studies are needed to establish best practices for surveillance, prevention, and treatment of CSVT in this population.</description><subject>Cardiac surgery</subject><subject>magnetic resonance imaging</subject><subject>magnetic resonance venography</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kM1LxDAQxYMoun78BYL06KXrJGnS5uBBFr9A8KJeQ5pMNctuu2a6gv-9WVc9Cg_mMG_m8X6MnXKYcuD6Yj6drzDQVIAQU1BZeodNOJi61I2Uu2wCeVPKqtYH7JBoDgCmAthnB1JpXVdVM2EvM0zYJrcoKPZrKj6wH_IY39KwbAeKVMQ-q3P9SIXrRkwFrdMrps-iG1Lhh_4V-zjm-zd0aSxCJHSEx2yvcwvCk595xJ5vrp9md-XD4-397Oqh9FKZsRROmqoSynAFovLSgYDaaAjYCKGC1mjAGW54qwJXuYgXjTFStcY3AWotj9j59u8qDe9rpNEuI3lcLFyPuYcVuWamkP9nq9xafRqIEnZ2leLSpU_LwW6A2rn9Bmo3QC2orE3A2U_Aul1i-Lv5JZgNl1sD5pofEZMlH7H3GGJCP9owxH8DvgBk_och</recordid><startdate>20220901</startdate><enddate>20220901</enddate><creator>Harrar, Dana B.</creator><creator>Goss, Margaret</creator><creator>Donofrio, Mary T.</creator><creator>Murnick, Jonathan</creator><creator>Reitz, Justus G.</creator><creator>Zhang, Anqing</creator><creator>Diab, Yaser</creator><creator>Meldau, Jennifer</creator><creator>Sinha, Pranava</creator><creator>Yerebakan, Can</creator><creator>Carpenter, Jessica L.</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6382-8479</orcidid></search><sort><creationdate>20220901</creationdate><title>Cerebral sinus venous thrombosis in infants after surgery for congenital heart disease</title><author>Harrar, Dana B. ; Goss, Margaret ; Donofrio, Mary T. ; Murnick, Jonathan ; Reitz, Justus G. ; Zhang, Anqing ; Diab, Yaser ; Meldau, Jennifer ; Sinha, Pranava ; Yerebakan, Can ; Carpenter, Jessica L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-2a394425915024c3a0207960de8225d66e90a9191b5d15476c289935b9c8d0763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Cardiac surgery</topic><topic>magnetic resonance imaging</topic><topic>magnetic resonance venography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harrar, Dana B.</creatorcontrib><creatorcontrib>Goss, Margaret</creatorcontrib><creatorcontrib>Donofrio, Mary T.</creatorcontrib><creatorcontrib>Murnick, Jonathan</creatorcontrib><creatorcontrib>Reitz, Justus G.</creatorcontrib><creatorcontrib>Zhang, Anqing</creatorcontrib><creatorcontrib>Diab, Yaser</creatorcontrib><creatorcontrib>Meldau, Jennifer</creatorcontrib><creatorcontrib>Sinha, Pranava</creatorcontrib><creatorcontrib>Yerebakan, Can</creatorcontrib><creatorcontrib>Carpenter, Jessica L.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harrar, Dana B.</au><au>Goss, Margaret</au><au>Donofrio, Mary T.</au><au>Murnick, Jonathan</au><au>Reitz, Justus G.</au><au>Zhang, Anqing</au><au>Diab, Yaser</au><au>Meldau, Jennifer</au><au>Sinha, Pranava</au><au>Yerebakan, Can</au><au>Carpenter, Jessica L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerebral sinus venous thrombosis in infants after surgery for congenital heart disease</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>2022-09-01</date><risdate>2022</risdate><volume>248</volume><spage>59</spage><epage>65.e3</epage><pages>59-65.e3</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><abstract>To determine the prevalence of and risk factors for cerebral sinus venous thrombosis (CSVT) in neonates undergoing congenital heart disease (CHD) repair.
Neonates who had CHD repair with cardiopulmonary bypass and a post-operative brain magnetic resonance image (MRI) between 2013 and 2019 at a single tertiary-care center were identified from institutional databases. Demographic, clinical, and surgical data were abstracted from these databases and from the medical record; 278 neonates with CHD had CPB, 184 of whom had a post-operative brain MRI.
Eight (4.3%) patients had a CSVT. Transposition of the great arteries with intact ventricular septum (D-TGA-IVS) (p<0.01) and interrupted aortic arch (IAA) (p=0.02) were associated with an increased risk for CSVT. Other risk factors for CSVT included cross-clamp time (98 minutes [interquartile range (IQR) 77.5-120] v. 67 minutes [IQR 44-102], p=0.03), units of platelets (3.63 [IQR 3-4] v. 2.17 [IQR 1-4], p<0.01) and packed red blood cells (0.81 [IQR 0.25-1] v. 1.21 [IQR 1-1], p=0.03) transfused intra-operatively, and time between surgery and MRI (10 days [IQR 7-12.5] v. 20 days [IQR 12-35], p<0.01). Five patients (62.5%) were treated with anticoagulation. All patients had complete or partial resolution of their CSVT, regardless of treatment.
Brain MRI after CPB in neonates revealed a low prevalence of CSVT (4.3%). Further studies are needed to establish best practices for surveillance, prevention, and treatment of CSVT in this population.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>35667448</pmid><doi>10.1016/j.jpeds.2022.05.056</doi><orcidid>https://orcid.org/0000-0001-6382-8479</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3476 |
| ispartof | The Journal of pediatrics, 2022-09, Vol.248, p.59-65.e3 |
| issn | 0022-3476 1097-6833 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2674002915 |
| source | Elsevier ScienceDirect Journals |
| subjects | Cardiac surgery magnetic resonance imaging magnetic resonance venography |
| title | Cerebral sinus venous thrombosis in infants after surgery for congenital heart disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T13%3A05%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cerebral%20sinus%20venous%20thrombosis%20in%20infants%20after%20surgery%20for%20congenital%20heart%20disease&rft.jtitle=The%20Journal%20of%20pediatrics&rft.au=Harrar,%20Dana%20B.&rft.date=2022-09-01&rft.volume=248&rft.spage=59&rft.epage=65.e3&rft.pages=59-65.e3&rft.issn=0022-3476&rft.eissn=1097-6833&rft_id=info:doi/10.1016/j.jpeds.2022.05.056&rft_dat=%3Cproquest_cross%3E2674002915%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2674002915&rft_id=info:pmid/35667448&rft_els_id=S0022347622005303&rfr_iscdi=true |