Overexpression of pigment epithelium-derived factor in breast cancer cell-derived exosomes induces M1 polarization in macrophages

•Transfection of MDA–MB-231 cells with PEDF expressing vector increases PEDF expression in isolated exosomes from transfected cell.•Exosomes can be used as a nanocarrier for delivery of PEDF into macrophages.•Exosome-mediated delivery of PEDF into macrophages results in the re-polarization of macrop...

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Veröffentlicht in:	Immunology letters 2022-08, Vol.248, p.31-36
Hauptverfasser:	Moradi-Chaleshtori, Maryam, Koochaki, Ameneh, Shojaei, Samaneh, Paryan, Mahdi, Safarzadeh, Mehrnoush, Hashemi, Seyed Mahmoud, Mohammadi-Yeganeh, Samira
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast cancer Exosome Macrophage polarization PEDF
Online-Zugang:	Volltext
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