The DUX4 protein is a co‐repressor of the progesterone and glucocorticoid nuclear receptors

DUX4 is a transcription factor required during early embryonic development in placental mammals. In this work, we provide evidence that DUX4 is a co‐repressor of nuclear receptors (NRs) of progesterone (PR) and glucocorticoids (GR). The DUX4 C‐ter and N‐ter regions, including the nuclear localizatio...

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Veröffentlicht in:	FEBS letters 2022-10, Vol.596 (20), p.2644-2658
Hauptverfasser:	Quintero, Julieta, Saad, Nizar Y., Pagnoni, Sabrina M., Jacquelin, Daniela K., Gatica, Laura V., Harper, Scott Q., Rosa, Alberto L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Co-Repressor Proteins co‐regulator DUX4 facioscapulohumeral muscular dystrophy Female Glucocorticoids Homeodomain Proteins - genetics Homeodomain Proteins - metabolism hormone nuclear receptor Mammals Muscular Dystrophy, Facioscapulohumeral - genetics Muscular Dystrophy, Facioscapulohumeral - metabolism Nuclear Localization Signals Placenta - metabolism Pregnancy Progesterone Receptors, Cytoplasmic and Nuclear Receptors, Glucocorticoid - genetics Transcription Factors
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