Generation of transmitochondrial cybrids using a microfluidic device

Mitochondrial cloning is a promising approach to achieve homoplasmic mitochondrial DNA (mtDNA) mutations. We previously developed a microfluidic device that performs single mitochondrion transfer from a mtDNA-intact cell to a mtDNA-less (ρ0) cell by promoting cytoplasmic connection through a microtu...

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Veröffentlicht in:	Experimental cell research 2022-09, Vol.418 (1), p.113233-113233, Article 113233
Hauptverfasser:	Wada, Ken-Ichi, Hosokawa, Kazuo, Ito, Yoshihiro, Maeda, Mizuo, Harada, Yui, Yonemitsu, Yoshikazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell fusion Cybrid Homoplasmy Microfluidic device Microtunnel Mitochondrial transfer
Online-Zugang:	Volltext
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