Serological biomarkers of type I, III and IV collagen turnover are associated with the presence and future progression of stricturing and penetrating Crohnʼs disease

Summary Background Increased collagen remodelling is a key pathophysiological component underlying intestinal stricture and fistula development in Crohn's disease (CD). Aims To investigate associations between serological biomarkers of collagen turnover and disease behaviour according to the Mo...

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Veröffentlicht in:	Alimentary pharmacology & therapeutics 2022-08, Vol.56 (4), p.675-693
Hauptverfasser:	Bourgonje, Arno R., Alexdottir, Marta S., Otten, Antonius T., Loveikyte, Roberta, Bay‐Jensen, Anne‐Christine, Pehrsson, Martin, Dullemen, Hendrik M., Visschedijk, Marijn C., Festen, Eleonora A. M., Weersma, Rinse K., Karsdal, Morten A., Faber, Klaas Nico, Mortensen, Joachim H., Dijkstra, Gerard
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers Cadmium Collagen Collagen (type I) Collagen (type III) Collagen (type IV) Crohn's disease Degradation Epitopes Matrix metalloproteinase Metalloproteinase Serology
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