Core-shell Pluronic F127/chitosan based nanoparticles for effective delivery of methotrexate in the management of rheumatoid arthritis

This study was designed to improve oral bioavailability of the methotrexate (MTX) by sustaining its release profile and integration into core-shell polymeric nanoparticles. The self-micellization and ionotropic gelation technique was employed which resulted into spherical shaped nanoparticles (181-4...

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Veröffentlicht in:	International journal of biological macromolecules 2022-07, Vol.213, p.465-477
Hauptverfasser:	Shafiq, Afifa, Madni, Asadullah, Khan, Shahzeb, Sultana, Humaira, Sumaira, Shah, Hassan, Khan, Safiullah, Rehman, Sadia, Nawaz, Mehwish
Format:	Artikel
Sprache:	eng
Schlagworte:	Methotrexate Oral drug delivery system Pluronic F127 Polymeric nanoparticles Rheumatoid arthritis
Online-Zugang:	Volltext
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