Irisin attenuates sepsis-induced cardiac dysfunction by attenuating inflammation-induced pyroptosis through a mitochondrial ubiquitin ligase-dependent mechanism

Sepsis-induced cardiac dysfunction is a leading cause of mortality in intensive care units. However, the molecular mechanisms underlying septic cardiomyopathy remain elusive. Irisin is a cleaved product of fibronectin type III domain-containing protein 5 (FNDC5) that protects the heart from ischemia...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2022-08, Vol.152, p.113199-113199, Article 113199
Hauptverfasser:	Xiong, Xiang, Lu, Linhe, Wang, Zhenyi, Ma, Jipeng, Shao, Yalan, Liu, Yang, Zhai, Mengen, Jin, Ping, Yang, Jian, Zheng, Qijun, Liu, Jincheng, Yang, Lifang
Format:	Artikel
Sprache:	eng
Schlagworte:	Gasdermin D Irisin (FNDC5) Mitochondrial ubiquitin ligase Pyroptosis Septic cardiomyopathy
Online-Zugang:	Volltext
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