PatDREB Transcription Factor Activates Patchoulol Synthase Gene Promoter and Positively Regulates Jasmonate-Induced Patchoulol Biosynthesis
The production of patchoulol in the patchouli (Pogostemon cablin) plant determines its application value, as it is the principal active sesquiterpene of essential oil extracted from this plant. Here, the promoter of patchoulol synthase gene (PatPTS pro) was isolated and found to be methyl jasmonate...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2022-06, Vol.70 (23), p.7188-7201 |
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| container_title | Journal of agricultural and food chemistry |
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| creator | Chen, Xiuzhen Wang, Xiaobing Wu, Daidi Li, Junren Huang, Huiling Wang, Xilin Zhan, Ruoting Chen, Likai |
| description | The production of patchoulol in the patchouli (Pogostemon cablin) plant determines its application value, as it is the principal active sesquiterpene of essential oil extracted from this plant. Here, the promoter of patchoulol synthase gene (PatPTS pro) was isolated and found to be methyl jasmonate (MeJA)-induced. A nucleus-localized AP2/ERF transcription factor PatDREB was identified as a transcription activator binding to PatPTS pro, regulating patchoulol biosynthesis through modulating the gene expression. PatDREB also interacts with jasmonate ZIM-domain 4 (JAZ4). Furthermore, PatDREB could physically interact with the MYB-related transcription factor PatSWC4 and synergistically facilitate patchoulol biosynthesis. However, the transcriptional activation activity of the PatDREB-PatSWC4 complex could be inhibited by PatJAZ4, and JA could reverse this interference. Overall, we demonstrated the positive roles of PatDREB and the PatDREB-PatSWC4 complex in regulating patchoulol production, which advance our understanding of the regulatory network of patchoulol biosynthesis. |
| doi_str_mv | 10.1021/acs.jafc.2c01660 |
| format | Article |
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Here, the promoter of patchoulol synthase gene (PatPTS pro) was isolated and found to be methyl jasmonate (MeJA)-induced. A nucleus-localized AP2/ERF transcription factor PatDREB was identified as a transcription activator binding to PatPTS pro, regulating patchoulol biosynthesis through modulating the gene expression. PatDREB also interacts with jasmonate ZIM-domain 4 (JAZ4). Furthermore, PatDREB could physically interact with the MYB-related transcription factor PatSWC4 and synergistically facilitate patchoulol biosynthesis. However, the transcriptional activation activity of the PatDREB-PatSWC4 complex could be inhibited by PatJAZ4, and JA could reverse this interference. Overall, we demonstrated the positive roles of PatDREB and the PatDREB-PatSWC4 complex in regulating patchoulol production, which advance our understanding of the regulatory network of patchoulol biosynthesis.</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/acs.jafc.2c01660</identifier><identifier>PMID: 35654756</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Biotechnology and Biological Transformations ; Cyclopentanes - pharmacology ; Gene Expression Regulation, Plant ; Isomerases ; Oxylipins - pharmacology ; Sesquiterpenes - metabolism ; Transcription Factors - genetics ; Transcription Factors - metabolism</subject><ispartof>Journal of agricultural and food chemistry, 2022-06, Vol.70 (23), p.7188-7201</ispartof><rights>2022 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a266t-30333f9451bb8c70560c5fa731a935861bf4369e58ba258715d2da15ce035a003</citedby><cites>FETCH-LOGICAL-a266t-30333f9451bb8c70560c5fa731a935861bf4369e58ba258715d2da15ce035a003</cites><orcidid>0000-0001-5769-7660 ; 0000-0001-7273-575X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.jafc.2c01660$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.jafc.2c01660$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2751,27055,27903,27904,56716,56766</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35654756$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Xiuzhen</creatorcontrib><creatorcontrib>Wang, Xiaobing</creatorcontrib><creatorcontrib>Wu, Daidi</creatorcontrib><creatorcontrib>Li, Junren</creatorcontrib><creatorcontrib>Huang, Huiling</creatorcontrib><creatorcontrib>Wang, Xilin</creatorcontrib><creatorcontrib>Zhan, Ruoting</creatorcontrib><creatorcontrib>Chen, Likai</creatorcontrib><title>PatDREB Transcription Factor Activates Patchoulol Synthase Gene Promoter and Positively Regulates Jasmonate-Induced Patchoulol Biosynthesis</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>The production of patchoulol in the patchouli (Pogostemon cablin) plant determines its application value, as it is the principal active sesquiterpene of essential oil extracted from this plant. Here, the promoter of patchoulol synthase gene (PatPTS pro) was isolated and found to be methyl jasmonate (MeJA)-induced. A nucleus-localized AP2/ERF transcription factor PatDREB was identified as a transcription activator binding to PatPTS pro, regulating patchoulol biosynthesis through modulating the gene expression. PatDREB also interacts with jasmonate ZIM-domain 4 (JAZ4). Furthermore, PatDREB could physically interact with the MYB-related transcription factor PatSWC4 and synergistically facilitate patchoulol biosynthesis. However, the transcriptional activation activity of the PatDREB-PatSWC4 complex could be inhibited by PatJAZ4, and JA could reverse this interference. Overall, we demonstrated the positive roles of PatDREB and the PatDREB-PatSWC4 complex in regulating patchoulol production, which advance our understanding of the regulatory network of patchoulol biosynthesis.</description><subject>Biotechnology and Biological Transformations</subject><subject>Cyclopentanes - pharmacology</subject><subject>Gene Expression Regulation, Plant</subject><subject>Isomerases</subject><subject>Oxylipins - pharmacology</subject><subject>Sesquiterpenes - metabolism</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctu2zAQRYmgQeI89lkVXHZRuUPRpORl3kkRIEYea2FEUY0CiXQ5VAF_Q3-6dOwU2WQ1szj3ADOXsRMBUwG5-IGGpq_YmmluQGgNO2wiVA6ZEqL8wiaQmKxUWuyzA6JXAChVAXtsXyqtZoXSE_Z3gfHi4fKMPwV0ZEK3jJ13_ApN9IGfmtj9wWiJJ8y8-LH3PX9cufiCZPm1dZYvgh98tIGja_jCU5cStl_xB_tr7N-iP5EG79Ka3bpmNLb5KDvrPK19ljo6Yrst9mSPt_OQPV9dPp3fZHf317fnp3cZ5lrHTIKUsp3PlKjr0hSgNBjVYiEFzqUqtajbmdRzq8oac1UWQjV5g0IZC1IhgDxk3zbeZfC_R0uxGjoytu_RWT9SletCyvSookwobFATPFGwbbUM3YBhVQmo1hVUqYJqXUG1rSBFvm7tYz3Y5n_g_ecJ-L4B3qJ-DC4d-7nvHxhulDU</recordid><startdate>20220615</startdate><enddate>20220615</enddate><creator>Chen, Xiuzhen</creator><creator>Wang, Xiaobing</creator><creator>Wu, Daidi</creator><creator>Li, Junren</creator><creator>Huang, Huiling</creator><creator>Wang, Xilin</creator><creator>Zhan, Ruoting</creator><creator>Chen, Likai</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5769-7660</orcidid><orcidid>https://orcid.org/0000-0001-7273-575X</orcidid></search><sort><creationdate>20220615</creationdate><title>PatDREB Transcription Factor Activates Patchoulol Synthase Gene Promoter and Positively Regulates Jasmonate-Induced Patchoulol Biosynthesis</title><author>Chen, Xiuzhen ; Wang, Xiaobing ; Wu, Daidi ; Li, Junren ; Huang, Huiling ; Wang, Xilin ; Zhan, Ruoting ; Chen, Likai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a266t-30333f9451bb8c70560c5fa731a935861bf4369e58ba258715d2da15ce035a003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biotechnology and Biological Transformations</topic><topic>Cyclopentanes - pharmacology</topic><topic>Gene Expression Regulation, Plant</topic><topic>Isomerases</topic><topic>Oxylipins - pharmacology</topic><topic>Sesquiterpenes - metabolism</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Xiuzhen</creatorcontrib><creatorcontrib>Wang, Xiaobing</creatorcontrib><creatorcontrib>Wu, Daidi</creatorcontrib><creatorcontrib>Li, Junren</creatorcontrib><creatorcontrib>Huang, Huiling</creatorcontrib><creatorcontrib>Wang, Xilin</creatorcontrib><creatorcontrib>Zhan, Ruoting</creatorcontrib><creatorcontrib>Chen, Likai</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Xiuzhen</au><au>Wang, Xiaobing</au><au>Wu, Daidi</au><au>Li, Junren</au><au>Huang, Huiling</au><au>Wang, Xilin</au><au>Zhan, Ruoting</au><au>Chen, Likai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PatDREB Transcription Factor Activates Patchoulol Synthase Gene Promoter and Positively Regulates Jasmonate-Induced Patchoulol Biosynthesis</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2022-06-15</date><risdate>2022</risdate><volume>70</volume><issue>23</issue><spage>7188</spage><epage>7201</epage><pages>7188-7201</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><abstract>The production of patchoulol in the patchouli (Pogostemon cablin) plant determines its application value, as it is the principal active sesquiterpene of essential oil extracted from this plant. Here, the promoter of patchoulol synthase gene (PatPTS pro) was isolated and found to be methyl jasmonate (MeJA)-induced. A nucleus-localized AP2/ERF transcription factor PatDREB was identified as a transcription activator binding to PatPTS pro, regulating patchoulol biosynthesis through modulating the gene expression. PatDREB also interacts with jasmonate ZIM-domain 4 (JAZ4). Furthermore, PatDREB could physically interact with the MYB-related transcription factor PatSWC4 and synergistically facilitate patchoulol biosynthesis. However, the transcriptional activation activity of the PatDREB-PatSWC4 complex could be inhibited by PatJAZ4, and JA could reverse this interference. Overall, we demonstrated the positive roles of PatDREB and the PatDREB-PatSWC4 complex in regulating patchoulol production, which advance our understanding of the regulatory network of patchoulol biosynthesis.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>35654756</pmid><doi>10.1021/acs.jafc.2c01660</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0001-5769-7660</orcidid><orcidid>https://orcid.org/0000-0001-7273-575X</orcidid></addata></record> |
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| subjects | Biotechnology and Biological Transformations Cyclopentanes - pharmacology Gene Expression Regulation, Plant Isomerases Oxylipins - pharmacology Sesquiterpenes - metabolism Transcription Factors - genetics Transcription Factors - metabolism |
| title | PatDREB Transcription Factor Activates Patchoulol Synthase Gene Promoter and Positively Regulates Jasmonate-Induced Patchoulol Biosynthesis |
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