The implications of cell‐free DNAs derived from tumor viruses as biomarkers of associated cancers
Cancer is still ranked as a leading cause of death according to estimates from the World Health Organization (WHO) and the strong link between tumor viruses and human cancers have been proved for almost six decades. Cell‐free DNA (cfDNA) has drawn enormous attention for its dynamic, instant, and non...
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| Veröffentlicht in: | Journal of medical virology 2022-10, Vol.94 (10), p.4677-4688 |
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| container_title | Journal of medical virology |
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| creator | Wang, Yiwei Li, Yanling Liang, Xinyu Xin, Shuyu Yang, Li Cao, Pengfei Jiang, Mingjuan Xin, Yujie Zhang, Senmiao Yang, Yang Lu, Jianhong |
| description | Cancer is still ranked as a leading cause of death according to estimates from the World Health Organization (WHO) and the strong link between tumor viruses and human cancers have been proved for almost six decades. Cell‐free DNA (cfDNA) has drawn enormous attention for its dynamic, instant, and noninvasive advantages as one popular type of cancer biomarker. cfDNAs are mainly released from apoptotic cells and exosomes released from cancer cells, including those infected with viruses. Although cfDNAs are present at low concentrations in peripheral blood, they can reflect tumor load with high sensitivity. Considering the relevance of the tumor viruses to the associated cancers, cfDNAs derived from viruses may serve as good biomarkers for the early screening, diagnosis, and treatment monitoring. In this review, we summarize the methods and newly developed analytic techniques for the detection of cfDNAs from different body fluids, and discuss the implications of cfDNAs derived from different tumor viruses in the detection and treatment monitoring of virus‐associated cancers. A better understanding of cfDNAs derived from tumor viruses may help formulate novel antitumoral strategies to decrease the burden of cancers that attributed to viruses. |
| doi_str_mv | 10.1002/jmv.27903 |
| format | Article |
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Cell‐free DNA (cfDNA) has drawn enormous attention for its dynamic, instant, and noninvasive advantages as one popular type of cancer biomarker. cfDNAs are mainly released from apoptotic cells and exosomes released from cancer cells, including those infected with viruses. Although cfDNAs are present at low concentrations in peripheral blood, they can reflect tumor load with high sensitivity. Considering the relevance of the tumor viruses to the associated cancers, cfDNAs derived from viruses may serve as good biomarkers for the early screening, diagnosis, and treatment monitoring. In this review, we summarize the methods and newly developed analytic techniques for the detection of cfDNAs from different body fluids, and discuss the implications of cfDNAs derived from different tumor viruses in the detection and treatment monitoring of virus‐associated cancers. A better understanding of cfDNAs derived from tumor viruses may help formulate novel antitumoral strategies to decrease the burden of cancers that attributed to viruses.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.27903</identifier><identifier>PMID: 35652186</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Apoptosis ; biomarker ; Biomarkers ; Body fluids ; Cancer ; cell‐free DNA ; Deoxyribonucleic acid ; DNA ; Exosomes ; Low concentrations ; Monitoring ; Peripheral blood ; tumor virus ; Tumor viruses ; Tumors ; Virology ; Viruses ; virus‐associated cancers</subject><ispartof>Journal of medical virology, 2022-10, Vol.94 (10), p.4677-4688</ispartof><rights>2022 Wiley Periodicals LLC.</rights><rights>This article is protected by copyright. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2833-ba7af79e5d87764abfa189e1192a60e1a89528fb95b161e6677d3fca714b28dd3</citedby><cites>FETCH-LOGICAL-c2833-ba7af79e5d87764abfa189e1192a60e1a89528fb95b161e6677d3fca714b28dd3</cites><orcidid>0000-0003-2999-8727 ; 0000-0002-4436-1217</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmv.27903$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmv.27903$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35652186$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Yiwei</creatorcontrib><creatorcontrib>Li, Yanling</creatorcontrib><creatorcontrib>Liang, Xinyu</creatorcontrib><creatorcontrib>Xin, Shuyu</creatorcontrib><creatorcontrib>Yang, Li</creatorcontrib><creatorcontrib>Cao, Pengfei</creatorcontrib><creatorcontrib>Jiang, Mingjuan</creatorcontrib><creatorcontrib>Xin, Yujie</creatorcontrib><creatorcontrib>Zhang, Senmiao</creatorcontrib><creatorcontrib>Yang, Yang</creatorcontrib><creatorcontrib>Lu, Jianhong</creatorcontrib><title>The implications of cell‐free DNAs derived from tumor viruses as biomarkers of associated cancers</title><title>Journal of medical virology</title><addtitle>J Med Virol</addtitle><description>Cancer is still ranked as a leading cause of death according to estimates from the World Health Organization (WHO) and the strong link between tumor viruses and human cancers have been proved for almost six decades. Cell‐free DNA (cfDNA) has drawn enormous attention for its dynamic, instant, and noninvasive advantages as one popular type of cancer biomarker. cfDNAs are mainly released from apoptotic cells and exosomes released from cancer cells, including those infected with viruses. Although cfDNAs are present at low concentrations in peripheral blood, they can reflect tumor load with high sensitivity. Considering the relevance of the tumor viruses to the associated cancers, cfDNAs derived from viruses may serve as good biomarkers for the early screening, diagnosis, and treatment monitoring. In this review, we summarize the methods and newly developed analytic techniques for the detection of cfDNAs from different body fluids, and discuss the implications of cfDNAs derived from different tumor viruses in the detection and treatment monitoring of virus‐associated cancers. A better understanding of cfDNAs derived from tumor viruses may help formulate novel antitumoral strategies to decrease the burden of cancers that attributed to viruses.</description><subject>Apoptosis</subject><subject>biomarker</subject><subject>Biomarkers</subject><subject>Body fluids</subject><subject>Cancer</subject><subject>cell‐free DNA</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Exosomes</subject><subject>Low concentrations</subject><subject>Monitoring</subject><subject>Peripheral blood</subject><subject>tumor virus</subject><subject>Tumor viruses</subject><subject>Tumors</subject><subject>Virology</subject><subject>Viruses</subject><subject>virus‐associated cancers</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp10MtOAyEUBmBiNFovC1_AkLjRxVRgOjAsTb3Hy0bdEoY5ROpMqdCpcecj-Iw-ibRVFyauTkI-_pzzI7RLSZ8Swo5G7azPhCT5CupRInkmiaCrqEfogGec02IDbcY4IoSUkrF1tJEXvGC05D1k7p8Au3bSOKOnzo8j9hYbaJrP9w8bAPDJ7XHENQQ3gxrb4Fs87Vof8MyFLkLEOuLK-VaHZwiLzzpGb5yeJm702KTXbbRmdRNh53tuoYez0_vhRXZ9d345PL7ODCvzPKu00FZIKOpSCD7QldW0lECpZJoToLqUBSttJYuKcgqcC1Hn1mhBBxUr6zrfQgfL3EnwLx3EqWpdnN-ix-C7qBgXTBAuCpno_h868l0Yp-1UIkyIgg3m6nCpTPAxBrBqElw69U1RoubNq9S8WjSf7N53Yle1UP_Kn6oTOFqCV9fA2_9J6urmcRn5BTj3jg4</recordid><startdate>202210</startdate><enddate>202210</enddate><creator>Wang, Yiwei</creator><creator>Li, Yanling</creator><creator>Liang, Xinyu</creator><creator>Xin, Shuyu</creator><creator>Yang, Li</creator><creator>Cao, Pengfei</creator><creator>Jiang, Mingjuan</creator><creator>Xin, Yujie</creator><creator>Zhang, Senmiao</creator><creator>Yang, Yang</creator><creator>Lu, Jianhong</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2999-8727</orcidid><orcidid>https://orcid.org/0000-0002-4436-1217</orcidid></search><sort><creationdate>202210</creationdate><title>The implications of cell‐free DNAs derived from tumor viruses as biomarkers of associated cancers</title><author>Wang, Yiwei ; 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Cell‐free DNA (cfDNA) has drawn enormous attention for its dynamic, instant, and noninvasive advantages as one popular type of cancer biomarker. cfDNAs are mainly released from apoptotic cells and exosomes released from cancer cells, including those infected with viruses. Although cfDNAs are present at low concentrations in peripheral blood, they can reflect tumor load with high sensitivity. Considering the relevance of the tumor viruses to the associated cancers, cfDNAs derived from viruses may serve as good biomarkers for the early screening, diagnosis, and treatment monitoring. In this review, we summarize the methods and newly developed analytic techniques for the detection of cfDNAs from different body fluids, and discuss the implications of cfDNAs derived from different tumor viruses in the detection and treatment monitoring of virus‐associated cancers. 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| subjects | Apoptosis biomarker Biomarkers Body fluids Cancer cell‐free DNA Deoxyribonucleic acid DNA Exosomes Low concentrations Monitoring Peripheral blood tumor virus Tumor viruses Tumors Virology Viruses virus‐associated cancers |
| title | The implications of cell‐free DNAs derived from tumor viruses as biomarkers of associated cancers |
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