Phosphoproteomic studies of alamandine signaling in CHO‐MrgD and human pancreatic carcinoma cells: An antiproliferative effect is unveiled

Alamandine is a heptapeptide from the renin‐angiotensin system (RAS) with similar structure/function to angiotensin‐(1‐7) [ang‐(1‐7)], but they act via different receptors. It remains elusive whether alamandine is an antiproliferative agent like ang‐(1‐7). The goal of this study was to evaluate the...

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Veröffentlicht in:	Proteomics (Weinheim) 2022-09, Vol.22 (17), p.e2100255-n/a
Hauptverfasser:	da Silva, Filipe Alex, Rodrigues‐Ribeiro, Lucas, Melo‐Braga, Marcella Nunes, Passos‐Silva, Danielle Gomes, Sampaio, Walkyria Oliveira, Gorshkov, Vladimir, Kjeldsen, Frank, Verano‐Braga, Thiago, Santos, Robson Augusto Souza
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein alamandine Angiotensin Anticancer properties Antiproliferatives cancer FOXO1 protein Humans Oligopeptides - metabolism Oligopeptides - pharmacology Pancreatic cancer Pancreatic carcinoma Pancreatic Neoplasms Phosphatidylinositol 3-Kinases phosphoproteomics Proteomics Receptors Receptors, G-Protein-Coupled - metabolism Renin renin‐angiotensin system Signaling Structure-function relationships TOR protein tumor
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