Apoptotic Cell Membrane-Inspired Polymer for Immunosuppression

Apoptotic Cell Membrane-Inspired Polymer for Immunosuppression

Apoptotic cell death serves important roles in homeostasis by eliminating dangerous, damaged, or unnecessary cells without causing an inflammatory response by externalizing phosphatidylserine to the outer leaflet in the phospholipid bilayer. In this study, we newly designed apoptotic cell membrane-i...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:ACS macro letters 2017-09, Vol.6 (9), p.1020-1024
Hauptverfasser: Nakagawa, Yasuhiro, Saitou, Atsuhiro, Aoyagi, Takao, Naito, Masanobu, Ebara, Mitsuhiro
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 1024
container_issue 9
container_start_page 1020
container_title ACS macro letters
container_volume 6
creator Nakagawa, Yasuhiro
Saitou, Atsuhiro
Aoyagi, Takao
Naito, Masanobu
Ebara, Mitsuhiro
description Apoptotic cell death serves important roles in homeostasis by eliminating dangerous, damaged, or unnecessary cells without causing an inflammatory response by externalizing phosphatidylserine to the outer leaflet in the phospholipid bilayer. In this study, we newly designed apoptotic cell membrane-inspired monomer and polymer which have the phosphoryl serine group as the anti-inflammatory functional moiety and demonstrate here for the first time that administration of an apoptotic cell membrane-inspired phosphorylserine polymer can protect murine macrophages (RAW 264.7) from lipopolysaccharide-induced inflammation. Interestingly, statistical copolymers with phosphorylcholine monomer that mimicked more precisely the apoptotic cell membrane result in more effective suppression of macrophage activation. This study provides new insights into the rational design of effective polymeric materials for anti-inflammatory therapies.
doi_str_mv 10.1021/acsmacrolett.7b00592
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2672705578</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2672705578</sourcerecordid><originalsourceid>FETCH-LOGICAL-a348t-6fd85955f03d35b0e2dea41e589861ef2ce7b25cecd1dd602b39ee4a928296883</originalsourceid><addsrcrecordid>eNp9kD9PwzAQxS0EolXpN0AoI0uK7cSOsyBVEX8qFcEAs-XEFylVHBs7GfrtcdWCOnHL3fDe3bsfQrcErwim5EE1wajG2x7GcVXUGLOSXqA5JZykhLPs8myeoWUIOxyLcSLK_BrNMsYZFoLO0ePaWTfasWuSCvo-eQNTezVAuhmC6zzo5MP2ewM-aa1PNsZMgw2Tcx5C6Oxwg65a1QdYnvoCfT0_fVav6fb9ZVOtt6nKcjGmvNWClYy1ONMZqzFQDSonwEQpOIGWNlDUlDXQaKI1x7TOSoBclVTQkguRLdD9ca_z9nuCMErThSYGjlHtFCTlBS0wY8VBmh-lEU8IHlrpfGeU30uC5QGePIcnT_Ci7e50YaoN6D_TL6oowEdBtMudnfwQH_5_5w-nkn8o</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2672705578</pqid></control><display><type>article</type><title>Apoptotic Cell Membrane-Inspired Polymer for Immunosuppression</title><source>ACS Publications</source><creator>Nakagawa, Yasuhiro ; Saitou, Atsuhiro ; Aoyagi, Takao ; Naito, Masanobu ; Ebara, Mitsuhiro</creator><creatorcontrib>Nakagawa, Yasuhiro ; Saitou, Atsuhiro ; Aoyagi, Takao ; Naito, Masanobu ; Ebara, Mitsuhiro</creatorcontrib><description>Apoptotic cell death serves important roles in homeostasis by eliminating dangerous, damaged, or unnecessary cells without causing an inflammatory response by externalizing phosphatidylserine to the outer leaflet in the phospholipid bilayer. In this study, we newly designed apoptotic cell membrane-inspired monomer and polymer which have the phosphoryl serine group as the anti-inflammatory functional moiety and demonstrate here for the first time that administration of an apoptotic cell membrane-inspired phosphorylserine polymer can protect murine macrophages (RAW 264.7) from lipopolysaccharide-induced inflammation. Interestingly, statistical copolymers with phosphorylcholine monomer that mimicked more precisely the apoptotic cell membrane result in more effective suppression of macrophage activation. This study provides new insights into the rational design of effective polymeric materials for anti-inflammatory therapies.</description><identifier>ISSN: 2161-1653</identifier><identifier>EISSN: 2161-1653</identifier><identifier>DOI: 10.1021/acsmacrolett.7b00592</identifier><identifier>PMID: 35650882</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><ispartof>ACS macro letters, 2017-09, Vol.6 (9), p.1020-1024</ispartof><rights>Copyright © 2017 American Chemical Society</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a348t-6fd85955f03d35b0e2dea41e589861ef2ce7b25cecd1dd602b39ee4a928296883</citedby><cites>FETCH-LOGICAL-a348t-6fd85955f03d35b0e2dea41e589861ef2ce7b25cecd1dd602b39ee4a928296883</cites><orcidid>0000-0002-7906-0350 ; 0000-0001-7198-819X ; 0000-0002-2152-3519</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acsmacrolett.7b00592$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acsmacrolett.7b00592$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2751,27055,27903,27904,56717,56767</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35650882$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakagawa, Yasuhiro</creatorcontrib><creatorcontrib>Saitou, Atsuhiro</creatorcontrib><creatorcontrib>Aoyagi, Takao</creatorcontrib><creatorcontrib>Naito, Masanobu</creatorcontrib><creatorcontrib>Ebara, Mitsuhiro</creatorcontrib><title>Apoptotic Cell Membrane-Inspired Polymer for Immunosuppression</title><title>ACS macro letters</title><addtitle>ACS Macro Lett</addtitle><description>Apoptotic cell death serves important roles in homeostasis by eliminating dangerous, damaged, or unnecessary cells without causing an inflammatory response by externalizing phosphatidylserine to the outer leaflet in the phospholipid bilayer. In this study, we newly designed apoptotic cell membrane-inspired monomer and polymer which have the phosphoryl serine group as the anti-inflammatory functional moiety and demonstrate here for the first time that administration of an apoptotic cell membrane-inspired phosphorylserine polymer can protect murine macrophages (RAW 264.7) from lipopolysaccharide-induced inflammation. Interestingly, statistical copolymers with phosphorylcholine monomer that mimicked more precisely the apoptotic cell membrane result in more effective suppression of macrophage activation. This study provides new insights into the rational design of effective polymeric materials for anti-inflammatory therapies.</description><issn>2161-1653</issn><issn>2161-1653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp9kD9PwzAQxS0EolXpN0AoI0uK7cSOsyBVEX8qFcEAs-XEFylVHBs7GfrtcdWCOnHL3fDe3bsfQrcErwim5EE1wajG2x7GcVXUGLOSXqA5JZykhLPs8myeoWUIOxyLcSLK_BrNMsYZFoLO0ePaWTfasWuSCvo-eQNTezVAuhmC6zzo5MP2ewM-aa1PNsZMgw2Tcx5C6Oxwg65a1QdYnvoCfT0_fVav6fb9ZVOtt6nKcjGmvNWClYy1ONMZqzFQDSonwEQpOIGWNlDUlDXQaKI1x7TOSoBclVTQkguRLdD9ca_z9nuCMErThSYGjlHtFCTlBS0wY8VBmh-lEU8IHlrpfGeU30uC5QGePIcnT_Ci7e50YaoN6D_TL6oowEdBtMudnfwQH_5_5w-nkn8o</recordid><startdate>20170919</startdate><enddate>20170919</enddate><creator>Nakagawa, Yasuhiro</creator><creator>Saitou, Atsuhiro</creator><creator>Aoyagi, Takao</creator><creator>Naito, Masanobu</creator><creator>Ebara, Mitsuhiro</creator><general>American Chemical Society</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7906-0350</orcidid><orcidid>https://orcid.org/0000-0001-7198-819X</orcidid><orcidid>https://orcid.org/0000-0002-2152-3519</orcidid></search><sort><creationdate>20170919</creationdate><title>Apoptotic Cell Membrane-Inspired Polymer for Immunosuppression</title><author>Nakagawa, Yasuhiro ; Saitou, Atsuhiro ; Aoyagi, Takao ; Naito, Masanobu ; Ebara, Mitsuhiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a348t-6fd85955f03d35b0e2dea41e589861ef2ce7b25cecd1dd602b39ee4a928296883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Nakagawa, Yasuhiro</creatorcontrib><creatorcontrib>Saitou, Atsuhiro</creatorcontrib><creatorcontrib>Aoyagi, Takao</creatorcontrib><creatorcontrib>Naito, Masanobu</creatorcontrib><creatorcontrib>Ebara, Mitsuhiro</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>ACS macro letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakagawa, Yasuhiro</au><au>Saitou, Atsuhiro</au><au>Aoyagi, Takao</au><au>Naito, Masanobu</au><au>Ebara, Mitsuhiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Apoptotic Cell Membrane-Inspired Polymer for Immunosuppression</atitle><jtitle>ACS macro letters</jtitle><addtitle>ACS Macro Lett</addtitle><date>2017-09-19</date><risdate>2017</risdate><volume>6</volume><issue>9</issue><spage>1020</spage><epage>1024</epage><pages>1020-1024</pages><issn>2161-1653</issn><eissn>2161-1653</eissn><abstract>Apoptotic cell death serves important roles in homeostasis by eliminating dangerous, damaged, or unnecessary cells without causing an inflammatory response by externalizing phosphatidylserine to the outer leaflet in the phospholipid bilayer. In this study, we newly designed apoptotic cell membrane-inspired monomer and polymer which have the phosphoryl serine group as the anti-inflammatory functional moiety and demonstrate here for the first time that administration of an apoptotic cell membrane-inspired phosphorylserine polymer can protect murine macrophages (RAW 264.7) from lipopolysaccharide-induced inflammation. Interestingly, statistical copolymers with phosphorylcholine monomer that mimicked more precisely the apoptotic cell membrane result in more effective suppression of macrophage activation. This study provides new insights into the rational design of effective polymeric materials for anti-inflammatory therapies.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>35650882</pmid><doi>10.1021/acsmacrolett.7b00592</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-7906-0350</orcidid><orcidid>https://orcid.org/0000-0001-7198-819X</orcidid><orcidid>https://orcid.org/0000-0002-2152-3519</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 2161-1653
ispartof ACS macro letters, 2017-09, Vol.6 (9), p.1020-1024
issn 2161-1653
2161-1653
language eng
recordid cdi_proquest_miscellaneous_2672705578
source ACS Publications
title Apoptotic Cell Membrane-Inspired Polymer for Immunosuppression
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T10%3A56%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Apoptotic%20Cell%20Membrane-Inspired%20Polymer%20for%20Immunosuppression&rft.jtitle=ACS%20macro%20letters&rft.au=Nakagawa,%20Yasuhiro&rft.date=2017-09-19&rft.volume=6&rft.issue=9&rft.spage=1020&rft.epage=1024&rft.pages=1020-1024&rft.issn=2161-1653&rft.eissn=2161-1653&rft_id=info:doi/10.1021/acsmacrolett.7b00592&rft_dat=%3Cproquest_cross%3E2672705578%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2672705578&rft_id=info:pmid/35650882&rfr_iscdi=true