HLA analysis of immune checkpoint inhibitor-induced and idiopathic isolated ACTH deficiency
Purpose Isolated adrenocorticotropic hormone deficiency is a rare disease; however, since immune check point inhibitors (ICIs) have become widely used, many more cases have been reported. In this study, we compared the human leukocyte antigen (HLA) signatures between ICI-induced isolated adrenocorti...
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| Veröffentlicht in: | Pituitary 2022-08, Vol.25 (4), p.615-621 |
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| creator | Ono, Mayo Fukuda, Izumi Nagao, Mototsugu Tomiyama, Keiko Okazaki-Hada, Mikiko Shuto, Yuki Kobayashi, Shunsuke Yamaguchi, Yuji Nagamine, Tomoko Nakajima, Yasushi Inagaki-Tanimura, Kyoko Sugihara, Hitoshi |
| description | Purpose
Isolated adrenocorticotropic hormone deficiency is a rare disease; however, since immune check point inhibitors (ICIs) have become widely used, many more cases have been reported. In this study, we compared the human leukocyte antigen (HLA) signatures between ICI-induced isolated adrenocorticotropic hormone deficiency (IAD) and idiopathic IAD (IIAD).
Design and methods:
Clinical features and HLA frequencies were compared among 13 patients with ICI-induced IAD, 8 patients with IIAD, and healthy controls. HLA frequencies of healthy controls were adopted from a HLA database of Japanese population.
Results
Age and body mass index were higher, while the rate of weight loss was lower, in patients with ICI-induced IAD than in those with IIAD. No HLA alleles had a significantly higher frequency in patients with ICI-induced IAD than in healthy controls, whereas the frequencies of HLA-DRB1*09:01, HLA-DQA1*03:02, and DQB1*03:03 were significantly higher in patients with IIAD than in healthy controls.
Conclusions
ICI-induced IAD and IIAD were different in terms of HLA frequencies. There were no specific HLAs related to ICI-induced IAD, whereas several HLAs in strong linkage disequilibrium were associated with IIAD. This might suggest that the two diseases have different pathological mechanisms. HLAs unique to IIAD may be helpful in predicting its pathophysiology. |
| doi_str_mv | 10.1007/s11102-022-01231-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2672704678</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2697194160</sourcerecordid><originalsourceid>FETCH-LOGICAL-c441t-aa06dd5ad9ab3af663c6174673b5f89c2ff7197d350225790c7ca79d990c99743</originalsourceid><addsrcrecordid>eNp9kEtLAzEUhYMotj7-gAsJuHEzmkwySbMsRa1QcFNBcBEyedjUmUmdzCz6702dquDCRcjl5jvn5h4ALjC6wQjx24gxRnmG8nRwTnCGD8AYF5xknCJymGoyYRmh-GUETmJcI5RkhB6DESlYQRDlY_A6X0yhalS1jT7C4KCv676xUK-sft8E33TQNytf-i60mW9Mr61JvIHe-LBR3cpr6GOoVJf609lyDo11Xnvb6O0ZOHKqivZ8f5-C5_u75WyeLZ4eHmfTRaYpxV2mFGLGFMoIVRLlGCOaYU4ZJ2XhJkLnznEsuCFF2rTgAmmuFRdGpEoITskpuB58N2346G3sZO2jtlWlGhv6KHPGc46S4SShV3_QdejbtP6OEmkMxQwlKh8o3YYYW-vkpvW1arcSI7mLXg7Ry_Qh-RW9xEl0ubfuy9qaH8l31gkgAxDTU_Nm29_Z_9h-AmVLjWs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2697194160</pqid></control><display><type>article</type><title>HLA analysis of immune checkpoint inhibitor-induced and idiopathic isolated ACTH deficiency</title><source>SpringerLink Journals - AutoHoldings</source><creator>Ono, Mayo ; Fukuda, Izumi ; Nagao, Mototsugu ; Tomiyama, Keiko ; Okazaki-Hada, Mikiko ; Shuto, Yuki ; Kobayashi, Shunsuke ; Yamaguchi, Yuji ; Nagamine, Tomoko ; Nakajima, Yasushi ; Inagaki-Tanimura, Kyoko ; Sugihara, Hitoshi</creator><creatorcontrib>Ono, Mayo ; Fukuda, Izumi ; Nagao, Mototsugu ; Tomiyama, Keiko ; Okazaki-Hada, Mikiko ; Shuto, Yuki ; Kobayashi, Shunsuke ; Yamaguchi, Yuji ; Nagamine, Tomoko ; Nakajima, Yasushi ; Inagaki-Tanimura, Kyoko ; Sugihara, Hitoshi</creatorcontrib><description>Purpose
Isolated adrenocorticotropic hormone deficiency is a rare disease; however, since immune check point inhibitors (ICIs) have become widely used, many more cases have been reported. In this study, we compared the human leukocyte antigen (HLA) signatures between ICI-induced isolated adrenocorticotropic hormone deficiency (IAD) and idiopathic IAD (IIAD).
Design and methods:
Clinical features and HLA frequencies were compared among 13 patients with ICI-induced IAD, 8 patients with IIAD, and healthy controls. HLA frequencies of healthy controls were adopted from a HLA database of Japanese population.
Results
Age and body mass index were higher, while the rate of weight loss was lower, in patients with ICI-induced IAD than in those with IIAD. No HLA alleles had a significantly higher frequency in patients with ICI-induced IAD than in healthy controls, whereas the frequencies of HLA-DRB1*09:01, HLA-DQA1*03:02, and DQB1*03:03 were significantly higher in patients with IIAD than in healthy controls.
Conclusions
ICI-induced IAD and IIAD were different in terms of HLA frequencies. There were no specific HLAs related to ICI-induced IAD, whereas several HLAs in strong linkage disequilibrium were associated with IIAD. This might suggest that the two diseases have different pathological mechanisms. HLAs unique to IIAD may be helpful in predicting its pathophysiology.</description><identifier>ISSN: 1386-341X</identifier><identifier>EISSN: 1573-7403</identifier><identifier>DOI: 10.1007/s11102-022-01231-1</identifier><identifier>PMID: 35653047</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adrenocorticotropic hormone ; Antibodies ; Antigens ; Apoptosis ; Bladder cancer ; Body mass index ; Body weight loss ; Diabetes ; Disease ; DQA1 protein ; Drb1 protein ; Endocrinology ; Histocompatibility antigen HLA ; Human Physiology ; Immune checkpoint ; Kidney cancer ; Linkage disequilibrium ; Medicine ; Medicine & Public Health ; Melanoma ; Pathophysiology ; Patients ; Rare diseases ; Thyroid gland</subject><ispartof>Pituitary, 2022-08, Vol.25 (4), p.615-621</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-aa06dd5ad9ab3af663c6174673b5f89c2ff7197d350225790c7ca79d990c99743</citedby><cites>FETCH-LOGICAL-c441t-aa06dd5ad9ab3af663c6174673b5f89c2ff7197d350225790c7ca79d990c99743</cites><orcidid>0000-0001-9115-9591</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11102-022-01231-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11102-022-01231-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35653047$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ono, Mayo</creatorcontrib><creatorcontrib>Fukuda, Izumi</creatorcontrib><creatorcontrib>Nagao, Mototsugu</creatorcontrib><creatorcontrib>Tomiyama, Keiko</creatorcontrib><creatorcontrib>Okazaki-Hada, Mikiko</creatorcontrib><creatorcontrib>Shuto, Yuki</creatorcontrib><creatorcontrib>Kobayashi, Shunsuke</creatorcontrib><creatorcontrib>Yamaguchi, Yuji</creatorcontrib><creatorcontrib>Nagamine, Tomoko</creatorcontrib><creatorcontrib>Nakajima, Yasushi</creatorcontrib><creatorcontrib>Inagaki-Tanimura, Kyoko</creatorcontrib><creatorcontrib>Sugihara, Hitoshi</creatorcontrib><title>HLA analysis of immune checkpoint inhibitor-induced and idiopathic isolated ACTH deficiency</title><title>Pituitary</title><addtitle>Pituitary</addtitle><addtitle>Pituitary</addtitle><description>Purpose
Isolated adrenocorticotropic hormone deficiency is a rare disease; however, since immune check point inhibitors (ICIs) have become widely used, many more cases have been reported. In this study, we compared the human leukocyte antigen (HLA) signatures between ICI-induced isolated adrenocorticotropic hormone deficiency (IAD) and idiopathic IAD (IIAD).
Design and methods:
Clinical features and HLA frequencies were compared among 13 patients with ICI-induced IAD, 8 patients with IIAD, and healthy controls. HLA frequencies of healthy controls were adopted from a HLA database of Japanese population.
Results
Age and body mass index were higher, while the rate of weight loss was lower, in patients with ICI-induced IAD than in those with IIAD. No HLA alleles had a significantly higher frequency in patients with ICI-induced IAD than in healthy controls, whereas the frequencies of HLA-DRB1*09:01, HLA-DQA1*03:02, and DQB1*03:03 were significantly higher in patients with IIAD than in healthy controls.
Conclusions
ICI-induced IAD and IIAD were different in terms of HLA frequencies. There were no specific HLAs related to ICI-induced IAD, whereas several HLAs in strong linkage disequilibrium were associated with IIAD. This might suggest that the two diseases have different pathological mechanisms. HLAs unique to IIAD may be helpful in predicting its pathophysiology.</description><subject>Adrenocorticotropic hormone</subject><subject>Antibodies</subject><subject>Antigens</subject><subject>Apoptosis</subject><subject>Bladder cancer</subject><subject>Body mass index</subject><subject>Body weight loss</subject><subject>Diabetes</subject><subject>Disease</subject><subject>DQA1 protein</subject><subject>Drb1 protein</subject><subject>Endocrinology</subject><subject>Histocompatibility antigen HLA</subject><subject>Human Physiology</subject><subject>Immune checkpoint</subject><subject>Kidney cancer</subject><subject>Linkage disequilibrium</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Melanoma</subject><subject>Pathophysiology</subject><subject>Patients</subject><subject>Rare diseases</subject><subject>Thyroid gland</subject><issn>1386-341X</issn><issn>1573-7403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kEtLAzEUhYMotj7-gAsJuHEzmkwySbMsRa1QcFNBcBEyedjUmUmdzCz6702dquDCRcjl5jvn5h4ALjC6wQjx24gxRnmG8nRwTnCGD8AYF5xknCJymGoyYRmh-GUETmJcI5RkhB6DESlYQRDlY_A6X0yhalS1jT7C4KCv676xUK-sft8E33TQNytf-i60mW9Mr61JvIHe-LBR3cpr6GOoVJf609lyDo11Xnvb6O0ZOHKqivZ8f5-C5_u75WyeLZ4eHmfTRaYpxV2mFGLGFMoIVRLlGCOaYU4ZJ2XhJkLnznEsuCFF2rTgAmmuFRdGpEoITskpuB58N2346G3sZO2jtlWlGhv6KHPGc46S4SShV3_QdejbtP6OEmkMxQwlKh8o3YYYW-vkpvW1arcSI7mLXg7Ry_Qh-RW9xEl0ubfuy9qaH8l31gkgAxDTU_Nm29_Z_9h-AmVLjWs</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Ono, Mayo</creator><creator>Fukuda, Izumi</creator><creator>Nagao, Mototsugu</creator><creator>Tomiyama, Keiko</creator><creator>Okazaki-Hada, Mikiko</creator><creator>Shuto, Yuki</creator><creator>Kobayashi, Shunsuke</creator><creator>Yamaguchi, Yuji</creator><creator>Nagamine, Tomoko</creator><creator>Nakajima, Yasushi</creator><creator>Inagaki-Tanimura, Kyoko</creator><creator>Sugihara, Hitoshi</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9115-9591</orcidid></search><sort><creationdate>20220801</creationdate><title>HLA analysis of immune checkpoint inhibitor-induced and idiopathic isolated ACTH deficiency</title><author>Ono, Mayo ; Fukuda, Izumi ; Nagao, Mototsugu ; Tomiyama, Keiko ; Okazaki-Hada, Mikiko ; Shuto, Yuki ; Kobayashi, Shunsuke ; Yamaguchi, Yuji ; Nagamine, Tomoko ; Nakajima, Yasushi ; Inagaki-Tanimura, Kyoko ; Sugihara, Hitoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-aa06dd5ad9ab3af663c6174673b5f89c2ff7197d350225790c7ca79d990c99743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adrenocorticotropic hormone</topic><topic>Antibodies</topic><topic>Antigens</topic><topic>Apoptosis</topic><topic>Bladder cancer</topic><topic>Body mass index</topic><topic>Body weight loss</topic><topic>Diabetes</topic><topic>Disease</topic><topic>DQA1 protein</topic><topic>Drb1 protein</topic><topic>Endocrinology</topic><topic>Histocompatibility antigen HLA</topic><topic>Human Physiology</topic><topic>Immune checkpoint</topic><topic>Kidney cancer</topic><topic>Linkage disequilibrium</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Melanoma</topic><topic>Pathophysiology</topic><topic>Patients</topic><topic>Rare diseases</topic><topic>Thyroid gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ono, Mayo</creatorcontrib><creatorcontrib>Fukuda, Izumi</creatorcontrib><creatorcontrib>Nagao, Mototsugu</creatorcontrib><creatorcontrib>Tomiyama, Keiko</creatorcontrib><creatorcontrib>Okazaki-Hada, Mikiko</creatorcontrib><creatorcontrib>Shuto, Yuki</creatorcontrib><creatorcontrib>Kobayashi, Shunsuke</creatorcontrib><creatorcontrib>Yamaguchi, Yuji</creatorcontrib><creatorcontrib>Nagamine, Tomoko</creatorcontrib><creatorcontrib>Nakajima, Yasushi</creatorcontrib><creatorcontrib>Inagaki-Tanimura, Kyoko</creatorcontrib><creatorcontrib>Sugihara, Hitoshi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pituitary</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ono, Mayo</au><au>Fukuda, Izumi</au><au>Nagao, Mototsugu</au><au>Tomiyama, Keiko</au><au>Okazaki-Hada, Mikiko</au><au>Shuto, Yuki</au><au>Kobayashi, Shunsuke</au><au>Yamaguchi, Yuji</au><au>Nagamine, Tomoko</au><au>Nakajima, Yasushi</au><au>Inagaki-Tanimura, Kyoko</au><au>Sugihara, Hitoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HLA analysis of immune checkpoint inhibitor-induced and idiopathic isolated ACTH deficiency</atitle><jtitle>Pituitary</jtitle><stitle>Pituitary</stitle><addtitle>Pituitary</addtitle><date>2022-08-01</date><risdate>2022</risdate><volume>25</volume><issue>4</issue><spage>615</spage><epage>621</epage><pages>615-621</pages><issn>1386-341X</issn><eissn>1573-7403</eissn><abstract>Purpose
Isolated adrenocorticotropic hormone deficiency is a rare disease; however, since immune check point inhibitors (ICIs) have become widely used, many more cases have been reported. In this study, we compared the human leukocyte antigen (HLA) signatures between ICI-induced isolated adrenocorticotropic hormone deficiency (IAD) and idiopathic IAD (IIAD).
Design and methods:
Clinical features and HLA frequencies were compared among 13 patients with ICI-induced IAD, 8 patients with IIAD, and healthy controls. HLA frequencies of healthy controls were adopted from a HLA database of Japanese population.
Results
Age and body mass index were higher, while the rate of weight loss was lower, in patients with ICI-induced IAD than in those with IIAD. No HLA alleles had a significantly higher frequency in patients with ICI-induced IAD than in healthy controls, whereas the frequencies of HLA-DRB1*09:01, HLA-DQA1*03:02, and DQB1*03:03 were significantly higher in patients with IIAD than in healthy controls.
Conclusions
ICI-induced IAD and IIAD were different in terms of HLA frequencies. There were no specific HLAs related to ICI-induced IAD, whereas several HLAs in strong linkage disequilibrium were associated with IIAD. This might suggest that the two diseases have different pathological mechanisms. HLAs unique to IIAD may be helpful in predicting its pathophysiology.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>35653047</pmid><doi>10.1007/s11102-022-01231-1</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-9115-9591</orcidid></addata></record> |
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| ispartof | Pituitary, 2022-08, Vol.25 (4), p.615-621 |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Adrenocorticotropic hormone Antibodies Antigens Apoptosis Bladder cancer Body mass index Body weight loss Diabetes Disease DQA1 protein Drb1 protein Endocrinology Histocompatibility antigen HLA Human Physiology Immune checkpoint Kidney cancer Linkage disequilibrium Medicine Medicine & Public Health Melanoma Pathophysiology Patients Rare diseases Thyroid gland |
| title | HLA analysis of immune checkpoint inhibitor-induced and idiopathic isolated ACTH deficiency |
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