Evaluation of antioxidant, enzyme inhibition, nitric oxide production inhibitory activities and chemical profiles of the active extracts from the medicinal and edible plant: Althaea officinalis
[Display omitted] •Phenolic and flavonoid of various extracts/fractions obtained from the aerial parts of Althaea officinalis were measured.•The Althaea officinalis extracts showed stronger antioxidant activity and excellent α-glucosidase, 5-lipoxygenase and nitric oxide inhibitory activities.•For t...
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| Veröffentlicht in: | Food research international 2022-06, Vol.156, p.111166-111166, Article 111166 |
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| creator | Xue, Tao-Tao Yang, Yuan-Gui Tang, Zhi-Shu Duan, Jin-Ao Song, Zhong-Xing Hu, Xiao-Hui Yang, Hao-Dong Xu, Hong-Bo |
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•Phenolic and flavonoid of various extracts/fractions obtained from the aerial parts of Althaea officinalis were measured.•The Althaea officinalis extracts showed stronger antioxidant activity and excellent α-glucosidase, 5-lipoxygenase and nitric oxide inhibitory activities.•For the first time, a total of 76 compounds, including 8 phenolic acids, 17 flavonoids, 6 coumarins, 9 triterpenes and 11 alkaloids have been identified in Althaea officinalis by UPLC-DAD-ESI-Q-TOF-MSn analysis.
To develop the medicinal and edible plant resources of Althaea officinalis Linn in Europe and other places, this study concentrated on the bioactive ingredients of its different extracts. The phytochemical compositions of MeOH extracts were evaluated by UPLC-DAD-ESI-Q-TOF-MSn analysis. The in vitro antioxidant properties, enzymes inhibitory effects and nitric oxide (NO) production inhibitory activities of fractions obtained from the aerial parts of Althaea officinalis (APAO) were evaluated. The results identified 76 compounds, including 8 phenolic acids, 17 flavonoids, 6 coumarins, 9 triterpenes and 11 alkaloids. Fr. C-2 of APAO was found to have the highest TPC (175.8 ± 1.5 mg GAE/g) and TFC (466.9 ± 5.0 mg RE/g) with the highest antioxidant capacity in DPPH, ABTS, CUPRAC, FRAP and β-carotene bleaching assays. Fr. A showed noticeable inhibition of α-glucosidase with an IC50 value of 3.8 ± 0.1 μg/mL. However, Fr. B displayed stronger inhibitory activity on 5-lipoxygenase than quercetin, with the IC50 value of 8.4 ± 1.6 μg/mL. In addition, Fr. B also possessed potent inhibitory activities on NO production toward LPS-activated RAW 264.7 Cells with an IC50 value of 15.7 ± 1.6 μg/mL. Our findings suggest that different Althaea officinalis extracts may be considered sources of phenolic and flavonoid compounds with high potential as natural antioxidants, anti-inflammatory agents and blood sugar regulators. In addition, they can also be used in food and nutraceutical products with enhanced bioactivities. |
| doi_str_mv | 10.1016/j.foodres.2022.111166 |
| format | Article |
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•Phenolic and flavonoid of various extracts/fractions obtained from the aerial parts of Althaea officinalis were measured.•The Althaea officinalis extracts showed stronger antioxidant activity and excellent α-glucosidase, 5-lipoxygenase and nitric oxide inhibitory activities.•For the first time, a total of 76 compounds, including 8 phenolic acids, 17 flavonoids, 6 coumarins, 9 triterpenes and 11 alkaloids have been identified in Althaea officinalis by UPLC-DAD-ESI-Q-TOF-MSn analysis.
To develop the medicinal and edible plant resources of Althaea officinalis Linn in Europe and other places, this study concentrated on the bioactive ingredients of its different extracts. The phytochemical compositions of MeOH extracts were evaluated by UPLC-DAD-ESI-Q-TOF-MSn analysis. The in vitro antioxidant properties, enzymes inhibitory effects and nitric oxide (NO) production inhibitory activities of fractions obtained from the aerial parts of Althaea officinalis (APAO) were evaluated. The results identified 76 compounds, including 8 phenolic acids, 17 flavonoids, 6 coumarins, 9 triterpenes and 11 alkaloids. Fr. C-2 of APAO was found to have the highest TPC (175.8 ± 1.5 mg GAE/g) and TFC (466.9 ± 5.0 mg RE/g) with the highest antioxidant capacity in DPPH, ABTS, CUPRAC, FRAP and β-carotene bleaching assays. Fr. A showed noticeable inhibition of α-glucosidase with an IC50 value of 3.8 ± 0.1 μg/mL. However, Fr. B displayed stronger inhibitory activity on 5-lipoxygenase than quercetin, with the IC50 value of 8.4 ± 1.6 μg/mL. In addition, Fr. B also possessed potent inhibitory activities on NO production toward LPS-activated RAW 264.7 Cells with an IC50 value of 15.7 ± 1.6 μg/mL. Our findings suggest that different Althaea officinalis extracts may be considered sources of phenolic and flavonoid compounds with high potential as natural antioxidants, anti-inflammatory agents and blood sugar regulators. In addition, they can also be used in food and nutraceutical products with enhanced bioactivities.</description><identifier>ISSN: 0963-9969</identifier><identifier>EISSN: 1873-7145</identifier><identifier>DOI: 10.1016/j.foodres.2022.111166</identifier><identifier>PMID: 35651032</identifier><language>eng</language><publisher>Canada: Elsevier Ltd</publisher><subject>Althaea officinalis ; Anti-inflammatory ; Antioxidant ; Chemical profiles ; Enzyme-inhibitory activity ; NO production</subject><ispartof>Food research international, 2022-06, Vol.156, p.111166-111166, Article 111166</ispartof><rights>2022 Elsevier Ltd</rights><rights>Copyright © 2022 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-b1771ae3289dd0baa0a079df758a766d3e209df7ea8d203ff090f931083c18b3</citedby><cites>FETCH-LOGICAL-c365t-b1771ae3289dd0baa0a079df758a766d3e209df7ea8d203ff090f931083c18b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.foodres.2022.111166$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35651032$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xue, Tao-Tao</creatorcontrib><creatorcontrib>Yang, Yuan-Gui</creatorcontrib><creatorcontrib>Tang, Zhi-Shu</creatorcontrib><creatorcontrib>Duan, Jin-Ao</creatorcontrib><creatorcontrib>Song, Zhong-Xing</creatorcontrib><creatorcontrib>Hu, Xiao-Hui</creatorcontrib><creatorcontrib>Yang, Hao-Dong</creatorcontrib><creatorcontrib>Xu, Hong-Bo</creatorcontrib><title>Evaluation of antioxidant, enzyme inhibition, nitric oxide production inhibitory activities and chemical profiles of the active extracts from the medicinal and edible plant: Althaea officinalis</title><title>Food research international</title><addtitle>Food Res Int</addtitle><description>[Display omitted]
•Phenolic and flavonoid of various extracts/fractions obtained from the aerial parts of Althaea officinalis were measured.•The Althaea officinalis extracts showed stronger antioxidant activity and excellent α-glucosidase, 5-lipoxygenase and nitric oxide inhibitory activities.•For the first time, a total of 76 compounds, including 8 phenolic acids, 17 flavonoids, 6 coumarins, 9 triterpenes and 11 alkaloids have been identified in Althaea officinalis by UPLC-DAD-ESI-Q-TOF-MSn analysis.
To develop the medicinal and edible plant resources of Althaea officinalis Linn in Europe and other places, this study concentrated on the bioactive ingredients of its different extracts. The phytochemical compositions of MeOH extracts were evaluated by UPLC-DAD-ESI-Q-TOF-MSn analysis. The in vitro antioxidant properties, enzymes inhibitory effects and nitric oxide (NO) production inhibitory activities of fractions obtained from the aerial parts of Althaea officinalis (APAO) were evaluated. The results identified 76 compounds, including 8 phenolic acids, 17 flavonoids, 6 coumarins, 9 triterpenes and 11 alkaloids. Fr. C-2 of APAO was found to have the highest TPC (175.8 ± 1.5 mg GAE/g) and TFC (466.9 ± 5.0 mg RE/g) with the highest antioxidant capacity in DPPH, ABTS, CUPRAC, FRAP and β-carotene bleaching assays. Fr. A showed noticeable inhibition of α-glucosidase with an IC50 value of 3.8 ± 0.1 μg/mL. However, Fr. B displayed stronger inhibitory activity on 5-lipoxygenase than quercetin, with the IC50 value of 8.4 ± 1.6 μg/mL. In addition, Fr. B also possessed potent inhibitory activities on NO production toward LPS-activated RAW 264.7 Cells with an IC50 value of 15.7 ± 1.6 μg/mL. Our findings suggest that different Althaea officinalis extracts may be considered sources of phenolic and flavonoid compounds with high potential as natural antioxidants, anti-inflammatory agents and blood sugar regulators. In addition, they can also be used in food and nutraceutical products with enhanced bioactivities.</description><subject>Althaea officinalis</subject><subject>Anti-inflammatory</subject><subject>Antioxidant</subject><subject>Chemical profiles</subject><subject>Enzyme-inhibitory activity</subject><subject>NO production</subject><issn>0963-9969</issn><issn>1873-7145</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNqFkc9u1DAQxi0EokvhEUA-cmgW_2nshAuqqlKQKnHp3XLssdarJC52sur27XgzJs3Ctb7YM_59M2N_hHzkbMsZV1_225CSz1C2ggmx5biUekU2vNGy0vyyfk02rFWyalvVnpF3pewZY6rW7VtyJmtVcybFhvy5Odh-tlNMI02B2hFPj9HjfkFhfDoOQOO4i11ciAs6xilHRxcE6ENOfnbP0hOT8pFazBwQh4LVPHU7GKKz_UKH2GMW20w7WDmg8DhlPBYachqeLwbw0cURJYseg67HXj2O9JVe9dPOgsUaYWVieU_eBNsX-HDaz8n995v76x_V3a_bn9dXd5WTqp6qjmvNLUjRtN6zzlpmmW590HVjtVJegmBLCLbxgskQWMtCKzlrpONNJ8_J57UsvuP3DGUyQywOepwL0lyMUFpodik1Q7ReUZdTKRmCechxsPloODOLeWZvTuaZxTyzmoe6T6cWc4ef8F_1zy0Evq0A4DsPEbIpLsLo8I8yuMn4FF9o8RfvQrMg</recordid><startdate>202206</startdate><enddate>202206</enddate><creator>Xue, Tao-Tao</creator><creator>Yang, Yuan-Gui</creator><creator>Tang, Zhi-Shu</creator><creator>Duan, Jin-Ao</creator><creator>Song, Zhong-Xing</creator><creator>Hu, Xiao-Hui</creator><creator>Yang, Hao-Dong</creator><creator>Xu, Hong-Bo</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202206</creationdate><title>Evaluation of antioxidant, enzyme inhibition, nitric oxide production inhibitory activities and chemical profiles of the active extracts from the medicinal and edible plant: Althaea officinalis</title><author>Xue, Tao-Tao ; Yang, Yuan-Gui ; Tang, Zhi-Shu ; Duan, Jin-Ao ; Song, Zhong-Xing ; Hu, Xiao-Hui ; Yang, Hao-Dong ; Xu, Hong-Bo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-b1771ae3289dd0baa0a079df758a766d3e209df7ea8d203ff090f931083c18b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Althaea officinalis</topic><topic>Anti-inflammatory</topic><topic>Antioxidant</topic><topic>Chemical profiles</topic><topic>Enzyme-inhibitory activity</topic><topic>NO production</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xue, Tao-Tao</creatorcontrib><creatorcontrib>Yang, Yuan-Gui</creatorcontrib><creatorcontrib>Tang, Zhi-Shu</creatorcontrib><creatorcontrib>Duan, Jin-Ao</creatorcontrib><creatorcontrib>Song, Zhong-Xing</creatorcontrib><creatorcontrib>Hu, Xiao-Hui</creatorcontrib><creatorcontrib>Yang, Hao-Dong</creatorcontrib><creatorcontrib>Xu, Hong-Bo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Food research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xue, Tao-Tao</au><au>Yang, Yuan-Gui</au><au>Tang, Zhi-Shu</au><au>Duan, Jin-Ao</au><au>Song, Zhong-Xing</au><au>Hu, Xiao-Hui</au><au>Yang, Hao-Dong</au><au>Xu, Hong-Bo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of antioxidant, enzyme inhibition, nitric oxide production inhibitory activities and chemical profiles of the active extracts from the medicinal and edible plant: Althaea officinalis</atitle><jtitle>Food research international</jtitle><addtitle>Food Res Int</addtitle><date>2022-06</date><risdate>2022</risdate><volume>156</volume><spage>111166</spage><epage>111166</epage><pages>111166-111166</pages><artnum>111166</artnum><issn>0963-9969</issn><eissn>1873-7145</eissn><abstract>[Display omitted]
•Phenolic and flavonoid of various extracts/fractions obtained from the aerial parts of Althaea officinalis were measured.•The Althaea officinalis extracts showed stronger antioxidant activity and excellent α-glucosidase, 5-lipoxygenase and nitric oxide inhibitory activities.•For the first time, a total of 76 compounds, including 8 phenolic acids, 17 flavonoids, 6 coumarins, 9 triterpenes and 11 alkaloids have been identified in Althaea officinalis by UPLC-DAD-ESI-Q-TOF-MSn analysis.
To develop the medicinal and edible plant resources of Althaea officinalis Linn in Europe and other places, this study concentrated on the bioactive ingredients of its different extracts. The phytochemical compositions of MeOH extracts were evaluated by UPLC-DAD-ESI-Q-TOF-MSn analysis. The in vitro antioxidant properties, enzymes inhibitory effects and nitric oxide (NO) production inhibitory activities of fractions obtained from the aerial parts of Althaea officinalis (APAO) were evaluated. The results identified 76 compounds, including 8 phenolic acids, 17 flavonoids, 6 coumarins, 9 triterpenes and 11 alkaloids. Fr. C-2 of APAO was found to have the highest TPC (175.8 ± 1.5 mg GAE/g) and TFC (466.9 ± 5.0 mg RE/g) with the highest antioxidant capacity in DPPH, ABTS, CUPRAC, FRAP and β-carotene bleaching assays. Fr. A showed noticeable inhibition of α-glucosidase with an IC50 value of 3.8 ± 0.1 μg/mL. However, Fr. B displayed stronger inhibitory activity on 5-lipoxygenase than quercetin, with the IC50 value of 8.4 ± 1.6 μg/mL. In addition, Fr. B also possessed potent inhibitory activities on NO production toward LPS-activated RAW 264.7 Cells with an IC50 value of 15.7 ± 1.6 μg/mL. Our findings suggest that different Althaea officinalis extracts may be considered sources of phenolic and flavonoid compounds with high potential as natural antioxidants, anti-inflammatory agents and blood sugar regulators. In addition, they can also be used in food and nutraceutical products with enhanced bioactivities.</abstract><cop>Canada</cop><pub>Elsevier Ltd</pub><pmid>35651032</pmid><doi>10.1016/j.foodres.2022.111166</doi><tpages>1</tpages></addata></record> |
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| subjects | Althaea officinalis Anti-inflammatory Antioxidant Chemical profiles Enzyme-inhibitory activity NO production |
| title | Evaluation of antioxidant, enzyme inhibition, nitric oxide production inhibitory activities and chemical profiles of the active extracts from the medicinal and edible plant: Althaea officinalis |
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