Phage display of environmental protein toxins and virulence factors reveals the prevalence, persistence, and genetics of antibody responses

Microbial exposures are crucial environmental factors that impact healthspan by sculpting the immune system and microbiota. Antibody profiling via Phage ImmunoPrecipitation Sequencing (PhIP-Seq) provides a high-throughput, cost-effective approach for detecting exposure and response to microbial prot...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2022-06, Vol.55 (6), p.1051-1066.e4
Hauptverfasser:	Angkeow, Julia W., Monaco, Daniel R., Chen, Athena, Venkataraman, Thiagarajan, Jayaraman, Sahana, Valencia, Cristian, Sie, Brandon M., Liechti, Thomas, Farhadi, Payam N., Funez-dePagnier, Gabriela, Sherman-Baust, Cheryl A., Wong, May Q., Ruczinski, Ingo, Caturegli, Patrizio, Sears, Cynthia L., Simner, Patricia J., Round, June L., Duggal, Priya, Laserson, Uri, Steiner, Theodore S., Sen, Ranjan, Lloyd, Thomas E., Roederer, Mario, Mammen, Andrew L., Longman, Randy S., Rider, Lisa G., Larman, H. Benjamin
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antibodies antibody epitoe profiling Antibody Formation Bacteriophages - genetics Crohn's disease Genome-Wide Association Study Humans humoral immunity Immunodominant Epitopes immunogenetics juvenile dermatomyositis microbiome Peptide Library Prevalence ToxScan Virulence Factors - genetics
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