The Dihydrouridine landscape from tRNA to mRNA: a perspective on synthesis, structural impact and function

The universal dihydrouridine (D) epitranscriptomic mark results from a reduction of uridine by the Dus family of NADPH-dependent reductases and is typically found within the eponym D-loop of tRNAs. Despite its apparent simplicity, D is structurally unique, with the potential to deeply affect the RNA...

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Veröffentlicht in:	RNA biology 2022-12, Vol.19 (1), p.735-750
Hauptverfasser:	Finet, Olivier, Yague-Sanz, Carlo, Marchand, Florian, Hermand, Damien
Format:	Artikel
Sprache:	eng
Schlagworte:	Dihydrouridine Dus epitranscriptome Humans Oxidoreductases - genetics Review RNA - chemistry RNA modification RNA, Messenger - genetics RNA, Transfer - chemistry RNA, Transfer - genetics Uridine - chemistry
Online-Zugang:	Volltext
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