Strategies for targeting the P2Y12 receptor in the central nervous system

[Display omitted] The purinergic 2Y type 12 receptor (P2Y12R) is a well-known biological target for anti-thrombotic drugs due to its role in platelet aggregation and blood clotting. While the importance of the P2Y12R in the periphery has been known for decades, much less is known about its expressio...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2022-09, Vol.71, p.128837-128837, Article 128837
Hauptverfasser:	Ma, Ben B., Montgomery, Andrew P., Chen, Biling, Kassiou, Michael, Danon, Jonathan J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood–brain barrier Central nervous system Microglia Molecular modelling P2Y12 PET imaging Physicochemical property prediction
Online-Zugang:	Volltext
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