Autoimmunity in Primary Immunodeficiencies (PID)
Primary immunodeficiency (PID) may impact any component of the immune system. The number of PID and immune dysregulation disorders is growing steadily with advancing genetic detection methods. These expansive recognition methods have changed the way we characterize PID. While PID were once character...
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| Veröffentlicht in: | Clinical reviews in allergy & immunology 2023-08, Vol.65 (1), p.1-18 |
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| creator | Padron, Grace T. Hernandez-Trujillo, Vivian P. |
| description | Primary immunodeficiency (PID) may impact any component of the immune system. The number of PID and immune dysregulation disorders is growing steadily with advancing genetic detection methods. These expansive recognition methods have changed the way we characterize PID. While PID were once characterized by their susceptibility to infection, the increase in genetic analysis has elucidated the intertwined relationship between PID and non-infectious manifestations including autoimmunity. The defects permitting opportunistic infections to take hold may also lead the way to the development of autoimmune disease. In some cases, it is the non-infectious complications that may be the presenting sign of PID autoimmune diseases, such as autoimmune cytopenia, enteropathy, endocrinopathies, and arthritis among others, have been reported in PID. While autoimmunity may occur with any PID, this review will look at certain immunodeficiencies most often associated with autoimmunity, as well as their diagnosis and management strategies. |
| doi_str_mv | 10.1007/s12016-022-08942-0 |
| format | Article |
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The number of PID and immune dysregulation disorders is growing steadily with advancing genetic detection methods. These expansive recognition methods have changed the way we characterize PID. While PID were once characterized by their susceptibility to infection, the increase in genetic analysis has elucidated the intertwined relationship between PID and non-infectious manifestations including autoimmunity. The defects permitting opportunistic infections to take hold may also lead the way to the development of autoimmune disease. In some cases, it is the non-infectious complications that may be the presenting sign of PID autoimmune diseases, such as autoimmune cytopenia, enteropathy, endocrinopathies, and arthritis among others, have been reported in PID. 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The number of PID and immune dysregulation disorders is growing steadily with advancing genetic detection methods. These expansive recognition methods have changed the way we characterize PID. While PID were once characterized by their susceptibility to infection, the increase in genetic analysis has elucidated the intertwined relationship between PID and non-infectious manifestations including autoimmunity. The defects permitting opportunistic infections to take hold may also lead the way to the development of autoimmune disease. In some cases, it is the non-infectious complications that may be the presenting sign of PID autoimmune diseases, such as autoimmune cytopenia, enteropathy, endocrinopathies, and arthritis among others, have been reported in PID. While autoimmunity may occur with any PID, this review will look at certain immunodeficiencies most often associated with autoimmunity, as well as their diagnosis and management strategies.</description><subject>Allergology</subject><subject>Analysis</subject><subject>Anemia</subject><subject>Antigens</subject><subject>Apoptosis</subject><subject>Arthritis</subject><subject>Autoimmune diseases</subject><subject>Autoimmunity</subject><subject>B cells</subject><subject>Consortia</subject><subject>Development and progression</subject><subject>Diabetes</subject><subject>Disease susceptibility</subject><subject>Endocrine disorders</subject><subject>Genetic analysis</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunodeficiency</subject><subject>Immunologic Deficiency Syndromes - diagnosis</subject><subject>Immunology</subject><subject>Infection</subject><subject>Inflammatory bowel disease</subject><subject>Internal Medicine</subject><subject>Kinases</subject><subject>Ligands</subject><subject>Lupus</subject><subject>Lymphocytes</subject><subject>Medical screening</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mutation</subject><subject>Pathogenesis</subject><subject>Primary immunodeficiencies</subject><subject>Proteins</subject><subject>T cell receptors</subject><subject>Thrombocytopenia</subject><subject>Thyroid diseases</subject><issn>1559-0267</issn><issn>1080-0549</issn><issn>1559-0267</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kclKBDEQhoMo7i_gQQYE0UOP2dM5Dq4DgnPQc-jJMhPpTrTTffDtzdjuiIQsVL6_qKofgAMExwhCcZYQhogXEOMClpLmcw1sI8ZkDnGx_u29BXZSeoQQw5LITbBFGKclEWgbwEnfRd80ffDdy8iH0az1TdW-jKarWDTWee1tyDuNTmbTi9M9sOGqOtn993sXPFxd3p_fFLd319PzyW2hqSBdIQWHBiGrSSUkc8yU2pFyjg3KJc-dRUxzgbikQjonqbGcGDpnnDBmKJKU7IKTIe9TG597mzrV-KRtXVfBxj6p3BUmSJZYZPToF_oY-zbk6hQuCSkh4xJ_UYuqtsoHF7u20qukaiIYx1RSDjM1_oPKy9jG6xjyPHL8h-D4m2Bpq7pbplj3nY8h_QTxAOo2ptRap56GUSsE1cpPNfipsp_qzU-1Eh2-t9bPG2s-JR8GZoAMQMpfYWHbr97_SfsKbZ6lgw</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Padron, Grace T.</creator><creator>Hernandez-Trujillo, Vivian P.</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9197-3996</orcidid></search><sort><creationdate>20230801</creationdate><title>Autoimmunity in Primary Immunodeficiencies (PID)</title><author>Padron, Grace T. ; Hernandez-Trujillo, Vivian P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-9760d11ec3a795f5d8cf38b2d1016bfe15c67169479ff94de63d4b56355d41943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Allergology</topic><topic>Analysis</topic><topic>Anemia</topic><topic>Antigens</topic><topic>Apoptosis</topic><topic>Arthritis</topic><topic>Autoimmune diseases</topic><topic>Autoimmunity</topic><topic>B cells</topic><topic>Consortia</topic><topic>Development and progression</topic><topic>Diabetes</topic><topic>Disease susceptibility</topic><topic>Endocrine disorders</topic><topic>Genetic analysis</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Immune system</topic><topic>Immunodeficiency</topic><topic>Immunologic Deficiency Syndromes - diagnosis</topic><topic>Immunology</topic><topic>Infection</topic><topic>Inflammatory bowel disease</topic><topic>Internal Medicine</topic><topic>Kinases</topic><topic>Ligands</topic><topic>Lupus</topic><topic>Lymphocytes</topic><topic>Medical screening</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mutation</topic><topic>Pathogenesis</topic><topic>Primary immunodeficiencies</topic><topic>Proteins</topic><topic>T cell receptors</topic><topic>Thrombocytopenia</topic><topic>Thyroid diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Padron, Grace T.</creatorcontrib><creatorcontrib>Hernandez-Trujillo, Vivian P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>Proquest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical reviews in allergy & immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Padron, Grace T.</au><au>Hernandez-Trujillo, Vivian P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Autoimmunity in Primary Immunodeficiencies (PID)</atitle><jtitle>Clinical reviews in allergy & immunology</jtitle><stitle>Clinic Rev Allerg Immunol</stitle><addtitle>Clin Rev Allergy Immunol</addtitle><date>2023-08-01</date><risdate>2023</risdate><volume>65</volume><issue>1</issue><spage>1</spage><epage>18</epage><pages>1-18</pages><issn>1559-0267</issn><issn>1080-0549</issn><eissn>1559-0267</eissn><abstract>Primary immunodeficiency (PID) may impact any component of the immune system. The number of PID and immune dysregulation disorders is growing steadily with advancing genetic detection methods. These expansive recognition methods have changed the way we characterize PID. While PID were once characterized by their susceptibility to infection, the increase in genetic analysis has elucidated the intertwined relationship between PID and non-infectious manifestations including autoimmunity. The defects permitting opportunistic infections to take hold may also lead the way to the development of autoimmune disease. In some cases, it is the non-infectious complications that may be the presenting sign of PID autoimmune diseases, such as autoimmune cytopenia, enteropathy, endocrinopathies, and arthritis among others, have been reported in PID. While autoimmunity may occur with any PID, this review will look at certain immunodeficiencies most often associated with autoimmunity, as well as their diagnosis and management strategies.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>35648371</pmid><doi>10.1007/s12016-022-08942-0</doi><tpages>18</tpages><orcidid>https://orcid.org/0000-0002-9197-3996</orcidid></addata></record> |
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| subjects | Allergology Analysis Anemia Antigens Apoptosis Arthritis Autoimmune diseases Autoimmunity B cells Consortia Development and progression Diabetes Disease susceptibility Endocrine disorders Genetic analysis Health aspects Humans Immune system Immunodeficiency Immunologic Deficiency Syndromes - diagnosis Immunology Infection Inflammatory bowel disease Internal Medicine Kinases Ligands Lupus Lymphocytes Medical screening Medicine Medicine & Public Health Mutation Pathogenesis Primary immunodeficiencies Proteins T cell receptors Thrombocytopenia Thyroid diseases |
| title | Autoimmunity in Primary Immunodeficiencies (PID) |
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