Differential MC5R loss in whales and manatees reveals convergent evolution to the marine environment
Melanocortin 5 receptor ( MC5R ), which is expressed in the terminally differentiated sebaceous gland, is a G protein-coupled receptor (GPCR). MC5R exists mostly in mammals but is completely lost in whales; only the relic of MC5R can be detected in manatees, and phenotypically, they have lost sebace...
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| Veröffentlicht in: | Development genes and evolution 2022-08, Vol.232 (2), p.81-87 |
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| container_title | Development genes and evolution |
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| creator | Liu, Jian Shu, Mingrong Liu, Shaobo Xue, Jingwen Chen, Haidi Li, Wen Zhou, Jingfan Amanullah, Amanullah Guan, Miao Bao, Ji Pu, Dan Deng, Cheng |
| description | Melanocortin 5 receptor (
MC5R
), which is expressed in the terminally differentiated sebaceous gland, is a G protein-coupled receptor (GPCR).
MC5R
exists mostly in mammals but is completely lost in whales; only the relic of
MC5R
can be detected in manatees, and phenotypically, they have lost sebaceous glands. Interestingly, whales and manatees are both aquatic mammals but have no immediate common ancestors. The loss of
MC5R
and sebaceous glands in whales and manatees is likely to be a result of convergent evolution. Here, we find that
MC5R
in whales and manatees are lost by two different mechanisms. Homologous recombination of
MC5R
in manatees and the insertion of reverse transcriptase in whales lead to the gene loss, respectively. On one hand, in manatees, there are two “TTATC” sequences flanking
MC5R
, and homologous recombination of the segments between the two “TTATC” sequences resulted in the partial loss of the sequence of
MC5R
. On the other hand, in whales, reverse transcriptase inserts between
MC2R
and
RNMT
on the chromosome led to the loss of
MC5R
. Based on these two different mechanisms for gene loss in whales and manatees, we finally concluded that
MC5R
loss might be the result of convergent evolution to the marine environment, and we explored the impact on biological function that is significant to environmental adaptation. |
| doi_str_mv | 10.1007/s00427-022-00688-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2672319588</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2695185500</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-da3df417166b31c77395d38787f17e25d5945952358268e2a23b3ff85bef8bbf3</originalsourceid><addsrcrecordid>eNp9kc1LHDEYxkNp6a7af8BDCfTiZWw-J8lRtvUDtgii4C1kZt64s8wmNplZ8b9vdK2CB0_hJb_neT8ehA4pOaaEqJ-ZEMFURRirCKm1rugnNKeCl1LQ289oTowwlRHidob2cl4TQpnh8iuacVkLzaico-5X7z0kCGPvBvxnIa_wEHPGfcAPKzdAxi50eOOCG6EUCbbghozbGLaQ7ooMwzYO09jHgMeIxxUUOPUBMIRtn2LYFOYAffFFBd9e3n10c_r7enFeLS_PLhYny6rlSo5V53jnBVW0rhtOW6W4kR3XSitPFTDZSSOkkYxLzWoNzDHecO-1bMDrpvF8Hx3tfO9T_DtBHu2mzy0MgwsQp2xZrRinRmpd0B_v0HWcUijTFcpIqqUkpFBsR7WpHCWBt_epL_s9WkrsUwZ2l4EtGdjnDCwtou8v1lOzge5V8v_oBeA7IJevcAfprfcHtv8ATb6RoQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2695185500</pqid></control><display><type>article</type><title>Differential MC5R loss in whales and manatees reveals convergent evolution to the marine environment</title><source>Springer Nature - Complete Springer Journals</source><creator>Liu, Jian ; Shu, Mingrong ; Liu, Shaobo ; Xue, Jingwen ; Chen, Haidi ; Li, Wen ; Zhou, Jingfan ; Amanullah, Amanullah ; Guan, Miao ; Bao, Ji ; Pu, Dan ; Deng, Cheng</creator><creatorcontrib>Liu, Jian ; Shu, Mingrong ; Liu, Shaobo ; Xue, Jingwen ; Chen, Haidi ; Li, Wen ; Zhou, Jingfan ; Amanullah, Amanullah ; Guan, Miao ; Bao, Ji ; Pu, Dan ; Deng, Cheng</creatorcontrib><description>Melanocortin 5 receptor (
MC5R
), which is expressed in the terminally differentiated sebaceous gland, is a G protein-coupled receptor (GPCR).
MC5R
exists mostly in mammals but is completely lost in whales; only the relic of
MC5R
can be detected in manatees, and phenotypically, they have lost sebaceous glands. Interestingly, whales and manatees are both aquatic mammals but have no immediate common ancestors. The loss of
MC5R
and sebaceous glands in whales and manatees is likely to be a result of convergent evolution. Here, we find that
MC5R
in whales and manatees are lost by two different mechanisms. Homologous recombination of
MC5R
in manatees and the insertion of reverse transcriptase in whales lead to the gene loss, respectively. On one hand, in manatees, there are two “TTATC” sequences flanking
MC5R
, and homologous recombination of the segments between the two “TTATC” sequences resulted in the partial loss of the sequence of
MC5R
. On the other hand, in whales, reverse transcriptase inserts between
MC2R
and
RNMT
on the chromosome led to the loss of
MC5R
. Based on these two different mechanisms for gene loss in whales and manatees, we finally concluded that
MC5R
loss might be the result of convergent evolution to the marine environment, and we explored the impact on biological function that is significant to environmental adaptation.</description><identifier>ISSN: 0949-944X</identifier><identifier>EISSN: 1432-041X</identifier><identifier>DOI: 10.1007/s00427-022-00688-1</identifier><identifier>PMID: 35648215</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animal Genetics and Genomics ; Biomedical and Life Sciences ; Cell Biology ; Cetacea ; Chromosomes ; Developmental Biology ; Evolution ; Evolutionary Biology ; G protein-coupled receptors ; Homologous recombination ; Life Sciences ; Marine environment ; Melanocortin ; Plant Genetics and Genomics ; RNA-directed DNA polymerase ; Sebaceous gland ; Short Communication ; Sirenia ; Zoology</subject><ispartof>Development genes and evolution, 2022-08, Vol.232 (2), p.81-87</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>Copyright Springer Nature B.V. Aug 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-da3df417166b31c77395d38787f17e25d5945952358268e2a23b3ff85bef8bbf3</citedby><cites>FETCH-LOGICAL-c375t-da3df417166b31c77395d38787f17e25d5945952358268e2a23b3ff85bef8bbf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00427-022-00688-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00427-022-00688-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,41475,42544,51306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35648215$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Jian</creatorcontrib><creatorcontrib>Shu, Mingrong</creatorcontrib><creatorcontrib>Liu, Shaobo</creatorcontrib><creatorcontrib>Xue, Jingwen</creatorcontrib><creatorcontrib>Chen, Haidi</creatorcontrib><creatorcontrib>Li, Wen</creatorcontrib><creatorcontrib>Zhou, Jingfan</creatorcontrib><creatorcontrib>Amanullah, Amanullah</creatorcontrib><creatorcontrib>Guan, Miao</creatorcontrib><creatorcontrib>Bao, Ji</creatorcontrib><creatorcontrib>Pu, Dan</creatorcontrib><creatorcontrib>Deng, Cheng</creatorcontrib><title>Differential MC5R loss in whales and manatees reveals convergent evolution to the marine environment</title><title>Development genes and evolution</title><addtitle>Dev Genes Evol</addtitle><addtitle>Dev Genes Evol</addtitle><description>Melanocortin 5 receptor (
MC5R
), which is expressed in the terminally differentiated sebaceous gland, is a G protein-coupled receptor (GPCR).
MC5R
exists mostly in mammals but is completely lost in whales; only the relic of
MC5R
can be detected in manatees, and phenotypically, they have lost sebaceous glands. Interestingly, whales and manatees are both aquatic mammals but have no immediate common ancestors. The loss of
MC5R
and sebaceous glands in whales and manatees is likely to be a result of convergent evolution. Here, we find that
MC5R
in whales and manatees are lost by two different mechanisms. Homologous recombination of
MC5R
in manatees and the insertion of reverse transcriptase in whales lead to the gene loss, respectively. On one hand, in manatees, there are two “TTATC” sequences flanking
MC5R
, and homologous recombination of the segments between the two “TTATC” sequences resulted in the partial loss of the sequence of
MC5R
. On the other hand, in whales, reverse transcriptase inserts between
MC2R
and
RNMT
on the chromosome led to the loss of
MC5R
. Based on these two different mechanisms for gene loss in whales and manatees, we finally concluded that
MC5R
loss might be the result of convergent evolution to the marine environment, and we explored the impact on biological function that is significant to environmental adaptation.</description><subject>Animal Genetics and Genomics</subject><subject>Biomedical and Life Sciences</subject><subject>Cell Biology</subject><subject>Cetacea</subject><subject>Chromosomes</subject><subject>Developmental Biology</subject><subject>Evolution</subject><subject>Evolutionary Biology</subject><subject>G protein-coupled receptors</subject><subject>Homologous recombination</subject><subject>Life Sciences</subject><subject>Marine environment</subject><subject>Melanocortin</subject><subject>Plant Genetics and Genomics</subject><subject>RNA-directed DNA polymerase</subject><subject>Sebaceous gland</subject><subject>Short Communication</subject><subject>Sirenia</subject><subject>Zoology</subject><issn>0949-944X</issn><issn>1432-041X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc1LHDEYxkNp6a7af8BDCfTiZWw-J8lRtvUDtgii4C1kZt64s8wmNplZ8b9vdK2CB0_hJb_neT8ehA4pOaaEqJ-ZEMFURRirCKm1rugnNKeCl1LQ289oTowwlRHidob2cl4TQpnh8iuacVkLzaico-5X7z0kCGPvBvxnIa_wEHPGfcAPKzdAxi50eOOCG6EUCbbghozbGLaQ7ooMwzYO09jHgMeIxxUUOPUBMIRtn2LYFOYAffFFBd9e3n10c_r7enFeLS_PLhYny6rlSo5V53jnBVW0rhtOW6W4kR3XSitPFTDZSSOkkYxLzWoNzDHecO-1bMDrpvF8Hx3tfO9T_DtBHu2mzy0MgwsQp2xZrRinRmpd0B_v0HWcUijTFcpIqqUkpFBsR7WpHCWBt_epL_s9WkrsUwZ2l4EtGdjnDCwtou8v1lOzge5V8v_oBeA7IJevcAfprfcHtv8ATb6RoQ</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Liu, 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the marine environment</title><author>Liu, Jian ; Shu, Mingrong ; Liu, Shaobo ; Xue, Jingwen ; Chen, Haidi ; Li, Wen ; Zhou, Jingfan ; Amanullah, Amanullah ; Guan, Miao ; Bao, Ji ; Pu, Dan ; Deng, Cheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-da3df417166b31c77395d38787f17e25d5945952358268e2a23b3ff85bef8bbf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animal Genetics and Genomics</topic><topic>Biomedical and Life Sciences</topic><topic>Cell Biology</topic><topic>Cetacea</topic><topic>Chromosomes</topic><topic>Developmental Biology</topic><topic>Evolution</topic><topic>Evolutionary Biology</topic><topic>G protein-coupled receptors</topic><topic>Homologous recombination</topic><topic>Life Sciences</topic><topic>Marine environment</topic><topic>Melanocortin</topic><topic>Plant Genetics and Genomics</topic><topic>RNA-directed DNA polymerase</topic><topic>Sebaceous gland</topic><topic>Short Communication</topic><topic>Sirenia</topic><topic>Zoology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Jian</creatorcontrib><creatorcontrib>Shu, Mingrong</creatorcontrib><creatorcontrib>Liu, Shaobo</creatorcontrib><creatorcontrib>Xue, Jingwen</creatorcontrib><creatorcontrib>Chen, Haidi</creatorcontrib><creatorcontrib>Li, Wen</creatorcontrib><creatorcontrib>Zhou, Jingfan</creatorcontrib><creatorcontrib>Amanullah, Amanullah</creatorcontrib><creatorcontrib>Guan, Miao</creatorcontrib><creatorcontrib>Bao, Ji</creatorcontrib><creatorcontrib>Pu, Dan</creatorcontrib><creatorcontrib>Deng, Cheng</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences 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Evol</addtitle><date>2022-08-01</date><risdate>2022</risdate><volume>232</volume><issue>2</issue><spage>81</spage><epage>87</epage><pages>81-87</pages><issn>0949-944X</issn><eissn>1432-041X</eissn><abstract>Melanocortin 5 receptor (
MC5R
), which is expressed in the terminally differentiated sebaceous gland, is a G protein-coupled receptor (GPCR).
MC5R
exists mostly in mammals but is completely lost in whales; only the relic of
MC5R
can be detected in manatees, and phenotypically, they have lost sebaceous glands. Interestingly, whales and manatees are both aquatic mammals but have no immediate common ancestors. The loss of
MC5R
and sebaceous glands in whales and manatees is likely to be a result of convergent evolution. Here, we find that
MC5R
in whales and manatees are lost by two different mechanisms. Homologous recombination of
MC5R
in manatees and the insertion of reverse transcriptase in whales lead to the gene loss, respectively. On one hand, in manatees, there are two “TTATC” sequences flanking
MC5R
, and homologous recombination of the segments between the two “TTATC” sequences resulted in the partial loss of the sequence of
MC5R
. On the other hand, in whales, reverse transcriptase inserts between
MC2R
and
RNMT
on the chromosome led to the loss of
MC5R
. Based on these two different mechanisms for gene loss in whales and manatees, we finally concluded that
MC5R
loss might be the result of convergent evolution to the marine environment, and we explored the impact on biological function that is significant to environmental adaptation.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35648215</pmid><doi>10.1007/s00427-022-00688-1</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Development genes and evolution, 2022-08, Vol.232 (2), p.81-87 |
| issn | 0949-944X 1432-041X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2672319588 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Animal Genetics and Genomics Biomedical and Life Sciences Cell Biology Cetacea Chromosomes Developmental Biology Evolution Evolutionary Biology G protein-coupled receptors Homologous recombination Life Sciences Marine environment Melanocortin Plant Genetics and Genomics RNA-directed DNA polymerase Sebaceous gland Short Communication Sirenia Zoology |
| title | Differential MC5R loss in whales and manatees reveals convergent evolution to the marine environment |
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