Oral fluid analysis to monitor recent exposure to synthetic cannabinoids in a high‐risk subpopulation
Among novel psychoactive substances, synthetic cannabinoid receptor agonists (SCRA) seem to have the widest diffusion in the population with no limitation to any particular demographic group. Information on drug consumption relies mostly on anonymized surveys and less on clinical or analytical data;...
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| Veröffentlicht in: | Journal of forensic sciences 2022-09, Vol.67 (5), p.1932-1937 |
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| container_end_page | 1937 |
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| container_issue | 5 |
| container_start_page | 1932 |
| container_title | Journal of forensic sciences |
| container_volume | 67 |
| creator | Pascali, Jennifer P. Dagoli, Sara Antonioni, Maina Facetti, Olivia Anzillotti, Luca Calò, Luca Affini, Giuseppe Fertonato Cantarelli, Barbara Cecchi, Rossana |
| description | Among novel psychoactive substances, synthetic cannabinoid receptor agonists (SCRA) seem to have the widest diffusion in the population with no limitation to any particular demographic group. Information on drug consumption relies mostly on anonymized surveys and less on clinical or analytical data; notwithstanding, the huge efforts constantly made to enroll subjects to gather epidemiological data. In the present study, we collected 66 oral fluid samples from volunteers in a drug rehabilitation center in 2019 and early 2020. A liquid chromatography–mass spectrometry method previously developed and validated by our Unit was applied to detect SCRA (n = 10) in oral fluid. Results proved the presence of synthetic cannabinoids at a positivity rate of almost 20%, with detection frequency HU211(5/13) > UR144/JWH122 (3/13) > JWH019/JWH081/AM2201 (1/13). Concentrations were in the range |
| doi_str_mv | 10.1111/1556-4029.15067 |
| format | Article |
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Information on drug consumption relies mostly on anonymized surveys and less on clinical or analytical data; notwithstanding, the huge efforts constantly made to enroll subjects to gather epidemiological data. In the present study, we collected 66 oral fluid samples from volunteers in a drug rehabilitation center in 2019 and early 2020. A liquid chromatography–mass spectrometry method previously developed and validated by our Unit was applied to detect SCRA (n = 10) in oral fluid. Results proved the presence of synthetic cannabinoids at a positivity rate of almost 20%, with detection frequency HU211(5/13) > UR144/JWH122 (3/13) > JWH019/JWH081/AM2201 (1/13). Concentrations were in the range < LOQ −0.36 ng/ml. Synthetic cannabinoids consumption had not been declared by any volunteer. This study enabled for the unprecedent detection of synthetic cannabinoids use in the territory of Parma (Italy) in a high‐risk subpopulation. The identified SCRA proved the persistence into the market of the “first‐generation” JWH family into the Italian territory and the marketing of relatively new ones (AM‐2201). Public health consequences represented by NPS consumption are still scarce; therefore, further studies are needed to understand the real diffusion in the population.</description><identifier>ISSN: 0022-1198</identifier><identifier>EISSN: 1556-4029</identifier><identifier>DOI: 10.1111/1556-4029.15067</identifier><identifier>PMID: 35642776</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Body fluids ; Diffusion ; Drug testing ; Forensic sciences ; forensic toxicology ; JWH‐081 ; JWH‐122 ; Liquid chromatography ; Mass spectrometry ; novel psychoactive substances ; oral fluid ; Psychotropic drugs ; Public health ; synthetic cannabinoids</subject><ispartof>Journal of forensic sciences, 2022-09, Vol.67 (5), p.1932-1937</ispartof><rights>2022 American Academy of Forensic Sciences.</rights><rights>2022 American Academy of Forensic Sciences</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4127-b6bfba761632a67f8cbf55e23c84f79492202b0ec3ccb26cffae2efee8d84aad3</citedby><cites>FETCH-LOGICAL-c4127-b6bfba761632a67f8cbf55e23c84f79492202b0ec3ccb26cffae2efee8d84aad3</cites><orcidid>0000-0002-1363-3400 ; 0000-0002-8451-7212</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1556-4029.15067$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1556-4029.15067$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35642776$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pascali, Jennifer P.</creatorcontrib><creatorcontrib>Dagoli, Sara</creatorcontrib><creatorcontrib>Antonioni, Maina</creatorcontrib><creatorcontrib>Facetti, Olivia</creatorcontrib><creatorcontrib>Anzillotti, Luca</creatorcontrib><creatorcontrib>Calò, Luca</creatorcontrib><creatorcontrib>Affini, Giuseppe Fertonato</creatorcontrib><creatorcontrib>Cantarelli, Barbara</creatorcontrib><creatorcontrib>Cecchi, Rossana</creatorcontrib><title>Oral fluid analysis to monitor recent exposure to synthetic cannabinoids in a high‐risk subpopulation</title><title>Journal of forensic sciences</title><addtitle>J Forensic Sci</addtitle><description>Among novel psychoactive substances, synthetic cannabinoid receptor agonists (SCRA) seem to have the widest diffusion in the population with no limitation to any particular demographic group. Information on drug consumption relies mostly on anonymized surveys and less on clinical or analytical data; notwithstanding, the huge efforts constantly made to enroll subjects to gather epidemiological data. In the present study, we collected 66 oral fluid samples from volunteers in a drug rehabilitation center in 2019 and early 2020. A liquid chromatography–mass spectrometry method previously developed and validated by our Unit was applied to detect SCRA (n = 10) in oral fluid. Results proved the presence of synthetic cannabinoids at a positivity rate of almost 20%, with detection frequency HU211(5/13) > UR144/JWH122 (3/13) > JWH019/JWH081/AM2201 (1/13). Concentrations were in the range < LOQ −0.36 ng/ml. Synthetic cannabinoids consumption had not been declared by any volunteer. This study enabled for the unprecedent detection of synthetic cannabinoids use in the territory of Parma (Italy) in a high‐risk subpopulation. The identified SCRA proved the persistence into the market of the “first‐generation” JWH family into the Italian territory and the marketing of relatively new ones (AM‐2201). Public health consequences represented by NPS consumption are still scarce; therefore, further studies are needed to understand the real diffusion in the population.</description><subject>Body fluids</subject><subject>Diffusion</subject><subject>Drug testing</subject><subject>Forensic sciences</subject><subject>forensic toxicology</subject><subject>JWH‐081</subject><subject>JWH‐122</subject><subject>Liquid chromatography</subject><subject>Mass spectrometry</subject><subject>novel psychoactive substances</subject><subject>oral fluid</subject><subject>Psychotropic drugs</subject><subject>Public health</subject><subject>synthetic cannabinoids</subject><issn>0022-1198</issn><issn>1556-4029</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNqFkb9u2zAQxomiQeO4nbsVBLpkUUxSEimNQZC_COClnQmSOsZMZVIhJSTe8gh5xjxJpNrxkCW3HHD3uw-H70PoJyUndKwFLUueFYTVJ7QkXHxBs_3kK5oRwlhGaV0doqOU7gkhnHL6DR3mJS-YEHyG7pZRtdi2g2uw8qrdJJdwH_A6eNeHiCMY8D2Gpy6kIcK0Shvfr6B3BhvlvdLOB9ck7DxWeOXuVq_PL9GlfzgNugvd0KreBf8dHVjVJvix63P09-L8z9lVdru8vD47vc1MQZnINNdWKzG-mTPFha2MtmUJLDdVYUVd1IwRpgmY3BjNuLFWAQMLUDVVoVSTz9HxVreL4WGA1Mu1SwbaVnkIQ5KMC5bTmtR8RH9_QO_DEEcPRkqQSvCyFhO12FImhpQiWNlFt1ZxIymRUwZyclxOjsv_GYwXv3a6g15Ds-ffTR-Bcgs8uhY2n-nJm4vlVvgNixeTqA</recordid><startdate>202209</startdate><enddate>202209</enddate><creator>Pascali, Jennifer P.</creator><creator>Dagoli, Sara</creator><creator>Antonioni, Maina</creator><creator>Facetti, Olivia</creator><creator>Anzillotti, Luca</creator><creator>Calò, Luca</creator><creator>Affini, Giuseppe Fertonato</creator><creator>Cantarelli, Barbara</creator><creator>Cecchi, Rossana</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K7.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1363-3400</orcidid><orcidid>https://orcid.org/0000-0002-8451-7212</orcidid></search><sort><creationdate>202209</creationdate><title>Oral fluid analysis to monitor recent exposure to synthetic cannabinoids in a high‐risk subpopulation</title><author>Pascali, Jennifer P. ; Dagoli, Sara ; Antonioni, Maina ; Facetti, Olivia ; Anzillotti, Luca ; Calò, Luca ; Affini, Giuseppe Fertonato ; Cantarelli, Barbara ; Cecchi, Rossana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4127-b6bfba761632a67f8cbf55e23c84f79492202b0ec3ccb26cffae2efee8d84aad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Body fluids</topic><topic>Diffusion</topic><topic>Drug testing</topic><topic>Forensic sciences</topic><topic>forensic toxicology</topic><topic>JWH‐081</topic><topic>JWH‐122</topic><topic>Liquid chromatography</topic><topic>Mass spectrometry</topic><topic>novel psychoactive substances</topic><topic>oral fluid</topic><topic>Psychotropic drugs</topic><topic>Public health</topic><topic>synthetic cannabinoids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pascali, Jennifer P.</creatorcontrib><creatorcontrib>Dagoli, Sara</creatorcontrib><creatorcontrib>Antonioni, Maina</creatorcontrib><creatorcontrib>Facetti, Olivia</creatorcontrib><creatorcontrib>Anzillotti, Luca</creatorcontrib><creatorcontrib>Calò, Luca</creatorcontrib><creatorcontrib>Affini, Giuseppe Fertonato</creatorcontrib><creatorcontrib>Cantarelli, Barbara</creatorcontrib><creatorcontrib>Cecchi, Rossana</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Criminal Justice (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of forensic sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pascali, Jennifer P.</au><au>Dagoli, Sara</au><au>Antonioni, Maina</au><au>Facetti, Olivia</au><au>Anzillotti, Luca</au><au>Calò, Luca</au><au>Affini, Giuseppe Fertonato</au><au>Cantarelli, Barbara</au><au>Cecchi, Rossana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral fluid analysis to monitor recent exposure to synthetic cannabinoids in a high‐risk subpopulation</atitle><jtitle>Journal of forensic sciences</jtitle><addtitle>J Forensic Sci</addtitle><date>2022-09</date><risdate>2022</risdate><volume>67</volume><issue>5</issue><spage>1932</spage><epage>1937</epage><pages>1932-1937</pages><issn>0022-1198</issn><eissn>1556-4029</eissn><abstract>Among novel psychoactive substances, synthetic cannabinoid receptor agonists (SCRA) seem to have the widest diffusion in the population with no limitation to any particular demographic group. 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| ispartof | Journal of forensic sciences, 2022-09, Vol.67 (5), p.1932-1937 |
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| language | eng |
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| source | Wiley Online Library All Journals |
| subjects | Body fluids Diffusion Drug testing Forensic sciences forensic toxicology JWH‐081 JWH‐122 Liquid chromatography Mass spectrometry novel psychoactive substances oral fluid Psychotropic drugs Public health synthetic cannabinoids |
| title | Oral fluid analysis to monitor recent exposure to synthetic cannabinoids in a high‐risk subpopulation |
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