Capsule-Based dry powder inhaler evaluation using CFD-DEM simulations and next generation impactor data

•Coupled CFD-DEM model built to predict the performance of common capsule DPIs.•Model predicts particle dynamics that affect powder aerosol characteristics.•Formulation and DPI design interplay affecting fine aerosol generation identified.•Model results correlate with experimental cascade impactor d...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2022-08, Vol.175, p.106226-106226, Article 106226
Hauptverfasser:	Almeida, Lucilla C., Bharadwaj, Rahul, Eliahu, Avi, Wassgren, Carl R., Nagapudi, Karthik, Muliadi, Ariel R.
Format:	Artikel
Sprache:	eng
Schlagworte:	CFD-DEM Computational fluid dynamics Discrete element method Dry powder inhalers Inhalation drug delivery
Online-Zugang:	Volltext
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