Association of microRNA polymorphisms with gastric cancer risk in the North Chinese Han population
Background and Aims: MicroRNA (miRNA) was found as a class of endogenous, important regulators of gene expression and involved in the regulation of many biological processes such as cell proliferation, apoptosis, and differentiation. Increasing studies have suggested that miR-146a, miR-196a2, and mi...
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| Veröffentlicht in: | Journal of cancer research and therapeutics 2022-04, Vol.18 (2), p.581-586 |
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| creator | Xin, Qian Shan, Shan Ding, E Jin, Mingxin Li, Bei Li, Jiangxia Liu, Qiji Yi, Cuihua Li, Jisheng |
| description | Background and Aims: MicroRNA (miRNA) was found as a class of endogenous, important regulators of gene expression and involved in the regulation of many biological processes such as cell proliferation, apoptosis, and differentiation. Increasing studies have suggested that miR-146a, miR-196a2, and miR-499 play important roles in the development processes of gastric cancer (GC). The aim of our study is to investigate whether three common miRNA polymorphisms are associated with the susceptibility of GC.
Materials and Methods: MiR-146a rs2910164 (G > C), miR-196a2 rs11614913 (C > T), and miR-499 rs3746444 (A > G) were genotyped by Taq-man assays in the present case-control study (386 patients, 341 controls). The associations between the selected miRNA single-nucleotide polymorphisms (SNPs) and the risk of GC were estimated by odds ratio (OR) with 95% confidence interval using logistic regression analysis.
Results: Our results showed that none of the three SNPs was associated with the risk of GC in allelic frequencies and multiple genetic models. Further stratified analysis with regard to clinical-pathological parameters of GC patients indicated that miR-146a rs2910164 SNP was strongly associated with age (OR = 0.53, P = 0.001) and gender (OR = 0.61, P = 0.006).
Conclusions: The present study showed no association of the investigated miRNA SNPs with the risk of GC in the north Chinese population. |
| doi_str_mv | 10.4103/jcrt.jcrt_74_21 |
| format | Article |
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Materials and Methods: MiR-146a rs2910164 (G > C), miR-196a2 rs11614913 (C > T), and miR-499 rs3746444 (A > G) were genotyped by Taq-man assays in the present case-control study (386 patients, 341 controls). The associations between the selected miRNA single-nucleotide polymorphisms (SNPs) and the risk of GC were estimated by odds ratio (OR) with 95% confidence interval using logistic regression analysis.
Results: Our results showed that none of the three SNPs was associated with the risk of GC in allelic frequencies and multiple genetic models. Further stratified analysis with regard to clinical-pathological parameters of GC patients indicated that miR-146a rs2910164 SNP was strongly associated with age (OR = 0.53, P = 0.001) and gender (OR = 0.61, P = 0.006).
Conclusions: The present study showed no association of the investigated miRNA SNPs with the risk of GC in the north Chinese population.</description><identifier>ISSN: 0973-1482</identifier><identifier>EISSN: 1998-4138</identifier><identifier>DOI: 10.4103/jcrt.jcrt_74_21</identifier><identifier>PMID: 35645131</identifier><language>eng</language><publisher>India: Wolters Kluwer India Pvt. Ltd</publisher><subject>Cancer ; Demographic aspects ; Gastric cancer ; Gene expression ; Genetic aspects ; MicroRNA ; MicroRNAs ; Oncology, Experimental ; Risk factors ; Single nucleotide polymorphisms ; Stomach cancer</subject><ispartof>Journal of cancer research and therapeutics, 2022-04, Vol.18 (2), p.581-586</ispartof><rights>COPYRIGHT 2022 Medknow Publications and Media Pvt. Ltd.</rights><rights>2022. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c483t-34513faaa3cae154f959078179e131fbebcb58b008b3c3d355c3eb827f96d3293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27435,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35645131$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xin, Qian</creatorcontrib><creatorcontrib>Shan, Shan</creatorcontrib><creatorcontrib>Ding, E</creatorcontrib><creatorcontrib>Jin, Mingxin</creatorcontrib><creatorcontrib>Li, Bei</creatorcontrib><creatorcontrib>Li, Jiangxia</creatorcontrib><creatorcontrib>Liu, Qiji</creatorcontrib><creatorcontrib>Yi, Cuihua</creatorcontrib><creatorcontrib>Li, Jisheng</creatorcontrib><title>Association of microRNA polymorphisms with gastric cancer risk in the North Chinese Han population</title><title>Journal of cancer research and therapeutics</title><addtitle>J Cancer Res Ther</addtitle><description>Background and Aims: MicroRNA (miRNA) was found as a class of endogenous, important regulators of gene expression and involved in the regulation of many biological processes such as cell proliferation, apoptosis, and differentiation. Increasing studies have suggested that miR-146a, miR-196a2, and miR-499 play important roles in the development processes of gastric cancer (GC). The aim of our study is to investigate whether three common miRNA polymorphisms are associated with the susceptibility of GC.
Materials and Methods: MiR-146a rs2910164 (G > C), miR-196a2 rs11614913 (C > T), and miR-499 rs3746444 (A > G) were genotyped by Taq-man assays in the present case-control study (386 patients, 341 controls). The associations between the selected miRNA single-nucleotide polymorphisms (SNPs) and the risk of GC were estimated by odds ratio (OR) with 95% confidence interval using logistic regression analysis.
Results: Our results showed that none of the three SNPs was associated with the risk of GC in allelic frequencies and multiple genetic models. Further stratified analysis with regard to clinical-pathological parameters of GC patients indicated that miR-146a rs2910164 SNP was strongly associated with age (OR = 0.53, P = 0.001) and gender (OR = 0.61, P = 0.006).
Conclusions: The present study showed no association of the investigated miRNA SNPs with the risk of GC in the north Chinese population.</description><subject>Cancer</subject><subject>Demographic aspects</subject><subject>Gastric cancer</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>Oncology, Experimental</subject><subject>Risk factors</subject><subject>Single nucleotide polymorphisms</subject><subject>Stomach cancer</subject><issn>0973-1482</issn><issn>1998-4138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1ksFr2zAUxsXYWLNu592GYJddnEqWHElHE7p1UDoY21nIynOixJY8ySb0v5_ctCsbGQIJHr_v4z29D6H3lCw5Jexqb-O4nC8tuC7pC7SgSsmCUyZfogVRghWUy_ICvUlpT0glylK-RhesWvGKMrpATZ1SsM6MLngcWtw7G8P3uxoPobvvQxx2LvUJH924w1uTxugstsZbiDi6dMDO43EH-C7EDKx3zkMCfGN81g9T92D7Fr1qTZfg3eN7iX5-vv6xviluv335uq5vC8slGws2d9QaY5g1QCveqkoRIalQkDttG2hsU8mGENkwyzasqiyDRpaiVasNKxW7RJ9OvkMMvyZIo-5dstB1xkOYki5XomRU5Nkz-vEfdB-m6HN3M0VpSVeCP1Nb04F2vg1jNHY21bUgXDEmJMlUcYbagodouuChdbn8F788w-ezgfz5ZwVXJ0HeTEoRWj1E15t4rynRcwr0QwCeU5AVHx7Hm5oeNn_4p7VnoD4Bx9CNENOhm44QdWYPPhz_56srSfVTXthv4qXFUg</recordid><startdate>20220401</startdate><enddate>20220401</enddate><creator>Xin, Qian</creator><creator>Shan, Shan</creator><creator>Ding, E</creator><creator>Jin, Mingxin</creator><creator>Li, Bei</creator><creator>Li, Jiangxia</creator><creator>Liu, Qiji</creator><creator>Yi, Cuihua</creator><creator>Li, Jisheng</creator><general>Wolters Kluwer India Pvt. 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Increasing studies have suggested that miR-146a, miR-196a2, and miR-499 play important roles in the development processes of gastric cancer (GC). The aim of our study is to investigate whether three common miRNA polymorphisms are associated with the susceptibility of GC.
Materials and Methods: MiR-146a rs2910164 (G > C), miR-196a2 rs11614913 (C > T), and miR-499 rs3746444 (A > G) were genotyped by Taq-man assays in the present case-control study (386 patients, 341 controls). The associations between the selected miRNA single-nucleotide polymorphisms (SNPs) and the risk of GC were estimated by odds ratio (OR) with 95% confidence interval using logistic regression analysis.
Results: Our results showed that none of the three SNPs was associated with the risk of GC in allelic frequencies and multiple genetic models. Further stratified analysis with regard to clinical-pathological parameters of GC patients indicated that miR-146a rs2910164 SNP was strongly associated with age (OR = 0.53, P = 0.001) and gender (OR = 0.61, P = 0.006).
Conclusions: The present study showed no association of the investigated miRNA SNPs with the risk of GC in the north Chinese population.</abstract><cop>India</cop><pub>Wolters Kluwer India Pvt. Ltd</pub><pmid>35645131</pmid><doi>10.4103/jcrt.jcrt_74_21</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of cancer research and therapeutics, 2022-04, Vol.18 (2), p.581-586 |
| issn | 0973-1482 1998-4138 |
| language | eng |
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| source | Medknow Open Access Medical Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Cancer Demographic aspects Gastric cancer Gene expression Genetic aspects MicroRNA MicroRNAs Oncology, Experimental Risk factors Single nucleotide polymorphisms Stomach cancer |
| title | Association of microRNA polymorphisms with gastric cancer risk in the North Chinese Han population |
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