Platinum(IV) Prodrugs with Cancer Stem Cell Inhibitory Effects on Lung Cancer for Overcoming Drug Resistance

Acquired resistance remains a major barrier for the treatment of non-small cell lung cancer, while cancer stem cells (CSCs) usually lead to the occurrence of drug resistance. We herein report a series of platinum­(IV) prodrugs containing CSCs-inhibitory species derived from a known CSCs inhibitor BB...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of medicinal chemistry 2022-06, Vol.65 (11), p.7933-7945
Hauptverfasser:	Wang, Xinyi, Liu, Zhikun, Wang, Yuanjiang, Gou, Shaohua
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - therapeutic use Apoptosis Carcinoma, Non-Small-Cell Lung - drug therapy Cisplatin - pharmacology Cisplatin - therapeutic use Drug Resistance, Neoplasm Humans Lung Neoplasms - pathology Neoplastic Stem Cells Platinum - metabolism Platinum - pharmacology Prodrugs - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!