Effect of biphosphate salt on dipalmitoylphosphatidylcholine bilayer deformation by Tat polypeptide

Translocation of positively charged cell penetrating peptides (CPP) through cell membrane is important in drug delivery. Here we report all‐atom molecular dynamics simulations to investigate how a biphosphate salt in a solvent affects the interaction of a CPP, HIV‐1 Tat peptide with model dipalmitoy...

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Veröffentlicht in:	Biopolymers 2022-08, Vol.113 (8), p.e23518-n/a
Hauptverfasser:	Patra, Piya, Banerjee, Raja, Chakrabarti, Jaydeb
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell membranes cell penetrating peptide counterion condensation Deformation effects Dipalmitoyl phosphatidylcholine Drug delivery Glutamine HIV Human immunodeficiency virus lipid bilayer Lipid bilayers Lipids Localization Molecular dynamics Peptides Phospholipids Polypeptides Residues Solvents Tat protein Thickness
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