Correlating the patterns of diabetic macular edema, optical coherence tomography biomarkers and grade of diabetic retinopathy with stage of renal disease
Purpose To correlate optical coherence tomography (OCT)-based morphological patterns of diabetic macular edema (DME), biomarkers and grade of diabetic retinopathy (DR) in patients with various stages of chronic kidney disease (CKD) secondary to diabetes. Design Multicentric retrospective cross-secti...
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| Veröffentlicht in: | International ophthalmology 2022-11, Vol.42 (11), p.3333-3343 |
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| creator | Agarwal, Manisha Sachdeva, Mani Shah, Shalin Raman, Rajiv Rani, Padmaja K. Rajalakshmi, Ramachandran Sivaprasad, Sobha Vignesh, T. P. Ramasamy, Kim Madharia, Aishwarya Sen, Alok Sugumar, Shalini Behera, Umesh Chandra Rodrigues, Ann Maria Anantharaman, Giridhar Priya, Swati Majumdar, Atanu |
| description | Purpose
To correlate optical coherence tomography (OCT)-based morphological patterns of diabetic macular edema (DME), biomarkers and grade of diabetic retinopathy (DR) in patients with various stages of chronic kidney disease (CKD) secondary to diabetes.
Design
Multicentric retrospective cross-sectional study was conducted at seven centers across India.
Methods
Data from medical records of patients with DME and CKD were entered in a common excel sheet across all seven centers. Staging of CKD was based on estimated glomerular filtration rate (eGFR).
Results
The most common morphological pattern of DME was cystoid pattern (42%) followed by the mixed pattern (31%). The proportion of different morphological patterns did not significantly vary across various CKD stages (
p
= 0.836). The presence of external limiting membrane-ellipsoid zone (ELM-EZ) defects (
p
|
| doi_str_mv | 10.1007/s10792-022-02332-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2671267211</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2671267211</sourcerecordid><originalsourceid>FETCH-LOGICAL-c370t-d0a2ac51479f6d53b4bd9044783796ce575ff3a0c94dcb89c8e7306e4ab8b0953</originalsourceid><addsrcrecordid>eNp9kctu1TAQhi1ERS_wAiyQJTYsmuJLEp8s0RG9SJXYwNqa2JNzUpI42I6qPkrftnN6CqUskDW2Nf7mH9s_Y--lOJNCmM9JCtOoQqhdaK0K_YodycroQtVavP5rf8iOU7oRQjSmqd-wQ13VWpfKHLH7dYgRB8j9tOF5i3yGnDFOiYeO-x5azL3jI7hlgMjR4winPMyUhIG7sMWIk0Oewxg2EebtHW_7MEL8iTFxmDynrMcXYpHmKVAfgm_7vOUpw-YRIS1S9X1CSPiWHXQwJHz3tJ6wH-dfv68vi-tvF1frL9eF00bkwgtQ4CpZmqarfaXbsvWNKEuz0vRWh5Wpuk6DcE3pXbtq3AqNFjWW0K5a0VT6hH3a684x_FowZTv2yeEwwIRhSVbVRlIoKQn9-A96E5ZIdybK0KCWYkepPeViSCliZ-fY05fcWSnszji7N86ScfbROKup6MOT9NKO6P-U_HaKAL0HEh1NG4zPvf8j-wDMZKXG</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2727283701</pqid></control><display><type>article</type><title>Correlating the patterns of diabetic macular edema, optical coherence tomography biomarkers and grade of diabetic retinopathy with stage of renal disease</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Agarwal, Manisha ; Sachdeva, Mani ; Shah, Shalin ; Raman, Rajiv ; Rani, Padmaja K. ; Rajalakshmi, Ramachandran ; Sivaprasad, Sobha ; Vignesh, T. P. ; Ramasamy, Kim ; Madharia, Aishwarya ; Sen, Alok ; Sugumar, Shalini ; Behera, Umesh Chandra ; Rodrigues, Ann Maria ; Anantharaman, Giridhar ; Priya, Swati ; Majumdar, Atanu</creator><creatorcontrib>Agarwal, Manisha ; Sachdeva, Mani ; Shah, Shalin ; Raman, Rajiv ; Rani, Padmaja K. ; Rajalakshmi, Ramachandran ; Sivaprasad, Sobha ; Vignesh, T. P. ; Ramasamy, Kim ; Madharia, Aishwarya ; Sen, Alok ; Sugumar, Shalini ; Behera, Umesh Chandra ; Rodrigues, Ann Maria ; Anantharaman, Giridhar ; Priya, Swati ; Majumdar, Atanu ; India Retinal Disease Study group ; India Retinal Disease Study group</creatorcontrib><description>Purpose
To correlate optical coherence tomography (OCT)-based morphological patterns of diabetic macular edema (DME), biomarkers and grade of diabetic retinopathy (DR) in patients with various stages of chronic kidney disease (CKD) secondary to diabetes.
Design
Multicentric retrospective cross-sectional study was conducted at seven centers across India.
Methods
Data from medical records of patients with DME and CKD were entered in a common excel sheet across all seven centers. Staging of CKD was based on estimated glomerular filtration rate (eGFR).
Results
The most common morphological pattern of DME was cystoid pattern (42%) followed by the mixed pattern (31%). The proportion of different morphological patterns did not significantly vary across various CKD stages (
p
= 0.836). The presence of external limiting membrane-ellipsoid zone (ELM-EZ) defects (
p
< 0.001) and foveal sub-field thickness (
p
= 0.024) showed a direct correlation with the stage of CKD which was statistically significant. The presence of hyperreflective dots (HRD) and disorganization of inner retinal layers (DRIL) showed no significant correlation with the stage of CKD. Sight threatening DR was found to increase from 70% in CKD stage 3 to 82% in stages 4 and 5 of CKD, and this was statistically significant (
p
= 0.03).
Conclusion
Cystoid morphological pattern followed by mixed type was the most common pattern of DME on OCT found in patients suffering from stage 3 to 5 of CKD. However, the morphological patterns of DME did not significantly vary across various CKD stages. ELM-EZ defects may be considered as an important OCT biomarker for advanced stage of CKD.</description><identifier>ISSN: 1573-2630</identifier><identifier>ISSN: 0165-5701</identifier><identifier>EISSN: 1573-2630</identifier><identifier>DOI: 10.1007/s10792-022-02332-3</identifier><identifier>PMID: 35633427</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Biomarkers ; Correlation ; Cross-Sectional Studies ; Defects ; Diabetes ; Diabetes Mellitus ; Diabetic retinopathy ; Diabetic Retinopathy - complications ; Diabetic Retinopathy - diagnosis ; Edema ; Glomerular filtration rate ; Humans ; Kidney diseases ; Macular Edema - complications ; Macular Edema - etiology ; Medical records ; Medicine ; Medicine & Public Health ; Morphology ; Ophthalmology ; Optical Coherence Tomography ; Original Paper ; Patients ; Renal Insufficiency, Chronic - complications ; Retinopathy ; Retrospective Studies ; Statistical analysis ; Tomography ; Tomography, Optical Coherence - methods</subject><ispartof>International ophthalmology, 2022-11, Vol.42 (11), p.3333-3343</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer Nature B.V.</rights><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2022.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c370t-d0a2ac51479f6d53b4bd9044783796ce575ff3a0c94dcb89c8e7306e4ab8b0953</cites><orcidid>0000-0001-6040-6692 ; 0000-0003-0945-1994 ; 0000-0002-2277-001X ; 0000-0002-7063-6026 ; 0000-0003-2374-4187 ; 0000-0002-7254-8249 ; 0000-0001-8952-0659 ; 0000-0001-5842-0233 ; 0000-0001-7069-8238</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10792-022-02332-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10792-022-02332-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35633427$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Agarwal, Manisha</creatorcontrib><creatorcontrib>Sachdeva, Mani</creatorcontrib><creatorcontrib>Shah, Shalin</creatorcontrib><creatorcontrib>Raman, Rajiv</creatorcontrib><creatorcontrib>Rani, Padmaja K.</creatorcontrib><creatorcontrib>Rajalakshmi, Ramachandran</creatorcontrib><creatorcontrib>Sivaprasad, Sobha</creatorcontrib><creatorcontrib>Vignesh, T. P.</creatorcontrib><creatorcontrib>Ramasamy, Kim</creatorcontrib><creatorcontrib>Madharia, Aishwarya</creatorcontrib><creatorcontrib>Sen, Alok</creatorcontrib><creatorcontrib>Sugumar, Shalini</creatorcontrib><creatorcontrib>Behera, Umesh Chandra</creatorcontrib><creatorcontrib>Rodrigues, Ann Maria</creatorcontrib><creatorcontrib>Anantharaman, Giridhar</creatorcontrib><creatorcontrib>Priya, Swati</creatorcontrib><creatorcontrib>Majumdar, Atanu</creatorcontrib><creatorcontrib>India Retinal Disease Study group</creatorcontrib><creatorcontrib>India Retinal Disease Study group</creatorcontrib><title>Correlating the patterns of diabetic macular edema, optical coherence tomography biomarkers and grade of diabetic retinopathy with stage of renal disease</title><title>International ophthalmology</title><addtitle>Int Ophthalmol</addtitle><addtitle>Int Ophthalmol</addtitle><description>Purpose
To correlate optical coherence tomography (OCT)-based morphological patterns of diabetic macular edema (DME), biomarkers and grade of diabetic retinopathy (DR) in patients with various stages of chronic kidney disease (CKD) secondary to diabetes.
Design
Multicentric retrospective cross-sectional study was conducted at seven centers across India.
Methods
Data from medical records of patients with DME and CKD were entered in a common excel sheet across all seven centers. Staging of CKD was based on estimated glomerular filtration rate (eGFR).
Results
The most common morphological pattern of DME was cystoid pattern (42%) followed by the mixed pattern (31%). The proportion of different morphological patterns did not significantly vary across various CKD stages (
p
= 0.836). The presence of external limiting membrane-ellipsoid zone (ELM-EZ) defects (
p
< 0.001) and foveal sub-field thickness (
p
= 0.024) showed a direct correlation with the stage of CKD which was statistically significant. The presence of hyperreflective dots (HRD) and disorganization of inner retinal layers (DRIL) showed no significant correlation with the stage of CKD. Sight threatening DR was found to increase from 70% in CKD stage 3 to 82% in stages 4 and 5 of CKD, and this was statistically significant (
p
= 0.03).
Conclusion
Cystoid morphological pattern followed by mixed type was the most common pattern of DME on OCT found in patients suffering from stage 3 to 5 of CKD. However, the morphological patterns of DME did not significantly vary across various CKD stages. ELM-EZ defects may be considered as an important OCT biomarker for advanced stage of CKD.</description><subject>Biomarkers</subject><subject>Correlation</subject><subject>Cross-Sectional Studies</subject><subject>Defects</subject><subject>Diabetes</subject><subject>Diabetes Mellitus</subject><subject>Diabetic retinopathy</subject><subject>Diabetic Retinopathy - complications</subject><subject>Diabetic Retinopathy - diagnosis</subject><subject>Edema</subject><subject>Glomerular filtration rate</subject><subject>Humans</subject><subject>Kidney diseases</subject><subject>Macular Edema - complications</subject><subject>Macular Edema - etiology</subject><subject>Medical records</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Morphology</subject><subject>Ophthalmology</subject><subject>Optical Coherence Tomography</subject><subject>Original Paper</subject><subject>Patients</subject><subject>Renal Insufficiency, Chronic - complications</subject><subject>Retinopathy</subject><subject>Retrospective Studies</subject><subject>Statistical analysis</subject><subject>Tomography</subject><subject>Tomography, Optical Coherence - methods</subject><issn>1573-2630</issn><issn>0165-5701</issn><issn>1573-2630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kctu1TAQhi1ERS_wAiyQJTYsmuJLEp8s0RG9SJXYwNqa2JNzUpI42I6qPkrftnN6CqUskDW2Nf7mH9s_Y--lOJNCmM9JCtOoQqhdaK0K_YodycroQtVavP5rf8iOU7oRQjSmqd-wQ13VWpfKHLH7dYgRB8j9tOF5i3yGnDFOiYeO-x5azL3jI7hlgMjR4winPMyUhIG7sMWIk0Oewxg2EebtHW_7MEL8iTFxmDynrMcXYpHmKVAfgm_7vOUpw-YRIS1S9X1CSPiWHXQwJHz3tJ6wH-dfv68vi-tvF1frL9eF00bkwgtQ4CpZmqarfaXbsvWNKEuz0vRWh5Wpuk6DcE3pXbtq3AqNFjWW0K5a0VT6hH3a684x_FowZTv2yeEwwIRhSVbVRlIoKQn9-A96E5ZIdybK0KCWYkepPeViSCliZ-fY05fcWSnszji7N86ScfbROKup6MOT9NKO6P-U_HaKAL0HEh1NG4zPvf8j-wDMZKXG</recordid><startdate>20221101</startdate><enddate>20221101</enddate><creator>Agarwal, Manisha</creator><creator>Sachdeva, Mani</creator><creator>Shah, Shalin</creator><creator>Raman, Rajiv</creator><creator>Rani, Padmaja K.</creator><creator>Rajalakshmi, Ramachandran</creator><creator>Sivaprasad, Sobha</creator><creator>Vignesh, T. P.</creator><creator>Ramasamy, Kim</creator><creator>Madharia, Aishwarya</creator><creator>Sen, Alok</creator><creator>Sugumar, Shalini</creator><creator>Behera, Umesh Chandra</creator><creator>Rodrigues, Ann Maria</creator><creator>Anantharaman, Giridhar</creator><creator>Priya, Swati</creator><creator>Majumdar, Atanu</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6040-6692</orcidid><orcidid>https://orcid.org/0000-0003-0945-1994</orcidid><orcidid>https://orcid.org/0000-0002-2277-001X</orcidid><orcidid>https://orcid.org/0000-0002-7063-6026</orcidid><orcidid>https://orcid.org/0000-0003-2374-4187</orcidid><orcidid>https://orcid.org/0000-0002-7254-8249</orcidid><orcidid>https://orcid.org/0000-0001-8952-0659</orcidid><orcidid>https://orcid.org/0000-0001-5842-0233</orcidid><orcidid>https://orcid.org/0000-0001-7069-8238</orcidid></search><sort><creationdate>20221101</creationdate><title>Correlating the patterns of diabetic macular edema, optical coherence tomography biomarkers and grade of diabetic retinopathy with stage of renal disease</title><author>Agarwal, Manisha ; Sachdeva, Mani ; Shah, Shalin ; Raman, Rajiv ; Rani, Padmaja K. ; Rajalakshmi, Ramachandran ; Sivaprasad, Sobha ; Vignesh, T. P. ; Ramasamy, Kim ; Madharia, Aishwarya ; Sen, Alok ; Sugumar, Shalini ; Behera, Umesh Chandra ; Rodrigues, Ann Maria ; Anantharaman, Giridhar ; Priya, Swati ; Majumdar, Atanu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-d0a2ac51479f6d53b4bd9044783796ce575ff3a0c94dcb89c8e7306e4ab8b0953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biomarkers</topic><topic>Correlation</topic><topic>Cross-Sectional Studies</topic><topic>Defects</topic><topic>Diabetes</topic><topic>Diabetes Mellitus</topic><topic>Diabetic retinopathy</topic><topic>Diabetic Retinopathy - complications</topic><topic>Diabetic Retinopathy - diagnosis</topic><topic>Edema</topic><topic>Glomerular filtration rate</topic><topic>Humans</topic><topic>Kidney diseases</topic><topic>Macular Edema - complications</topic><topic>Macular Edema - etiology</topic><topic>Medical records</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Morphology</topic><topic>Ophthalmology</topic><topic>Optical Coherence Tomography</topic><topic>Original Paper</topic><topic>Patients</topic><topic>Renal Insufficiency, Chronic - complications</topic><topic>Retinopathy</topic><topic>Retrospective Studies</topic><topic>Statistical analysis</topic><topic>Tomography</topic><topic>Tomography, Optical Coherence - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Agarwal, Manisha</creatorcontrib><creatorcontrib>Sachdeva, Mani</creatorcontrib><creatorcontrib>Shah, Shalin</creatorcontrib><creatorcontrib>Raman, Rajiv</creatorcontrib><creatorcontrib>Rani, Padmaja K.</creatorcontrib><creatorcontrib>Rajalakshmi, Ramachandran</creatorcontrib><creatorcontrib>Sivaprasad, Sobha</creatorcontrib><creatorcontrib>Vignesh, T. P.</creatorcontrib><creatorcontrib>Ramasamy, Kim</creatorcontrib><creatorcontrib>Madharia, Aishwarya</creatorcontrib><creatorcontrib>Sen, Alok</creatorcontrib><creatorcontrib>Sugumar, Shalini</creatorcontrib><creatorcontrib>Behera, Umesh Chandra</creatorcontrib><creatorcontrib>Rodrigues, Ann Maria</creatorcontrib><creatorcontrib>Anantharaman, Giridhar</creatorcontrib><creatorcontrib>Priya, Swati</creatorcontrib><creatorcontrib>Majumdar, Atanu</creatorcontrib><creatorcontrib>India Retinal Disease Study group</creatorcontrib><creatorcontrib>India Retinal Disease Study group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Agarwal, Manisha</au><au>Sachdeva, Mani</au><au>Shah, Shalin</au><au>Raman, Rajiv</au><au>Rani, Padmaja K.</au><au>Rajalakshmi, Ramachandran</au><au>Sivaprasad, Sobha</au><au>Vignesh, T. P.</au><au>Ramasamy, Kim</au><au>Madharia, Aishwarya</au><au>Sen, Alok</au><au>Sugumar, Shalini</au><au>Behera, Umesh Chandra</au><au>Rodrigues, Ann Maria</au><au>Anantharaman, Giridhar</au><au>Priya, Swati</au><au>Majumdar, Atanu</au><aucorp>India Retinal Disease Study group</aucorp><aucorp>India Retinal Disease Study group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlating the patterns of diabetic macular edema, optical coherence tomography biomarkers and grade of diabetic retinopathy with stage of renal disease</atitle><jtitle>International ophthalmology</jtitle><stitle>Int Ophthalmol</stitle><addtitle>Int Ophthalmol</addtitle><date>2022-11-01</date><risdate>2022</risdate><volume>42</volume><issue>11</issue><spage>3333</spage><epage>3343</epage><pages>3333-3343</pages><issn>1573-2630</issn><issn>0165-5701</issn><eissn>1573-2630</eissn><abstract>Purpose
To correlate optical coherence tomography (OCT)-based morphological patterns of diabetic macular edema (DME), biomarkers and grade of diabetic retinopathy (DR) in patients with various stages of chronic kidney disease (CKD) secondary to diabetes.
Design
Multicentric retrospective cross-sectional study was conducted at seven centers across India.
Methods
Data from medical records of patients with DME and CKD were entered in a common excel sheet across all seven centers. Staging of CKD was based on estimated glomerular filtration rate (eGFR).
Results
The most common morphological pattern of DME was cystoid pattern (42%) followed by the mixed pattern (31%). The proportion of different morphological patterns did not significantly vary across various CKD stages (
p
= 0.836). The presence of external limiting membrane-ellipsoid zone (ELM-EZ) defects (
p
< 0.001) and foveal sub-field thickness (
p
= 0.024) showed a direct correlation with the stage of CKD which was statistically significant. The presence of hyperreflective dots (HRD) and disorganization of inner retinal layers (DRIL) showed no significant correlation with the stage of CKD. Sight threatening DR was found to increase from 70% in CKD stage 3 to 82% in stages 4 and 5 of CKD, and this was statistically significant (
p
= 0.03).
Conclusion
Cystoid morphological pattern followed by mixed type was the most common pattern of DME on OCT found in patients suffering from stage 3 to 5 of CKD. However, the morphological patterns of DME did not significantly vary across various CKD stages. ELM-EZ defects may be considered as an important OCT biomarker for advanced stage of CKD.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>35633427</pmid><doi>10.1007/s10792-022-02332-3</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-6040-6692</orcidid><orcidid>https://orcid.org/0000-0003-0945-1994</orcidid><orcidid>https://orcid.org/0000-0002-2277-001X</orcidid><orcidid>https://orcid.org/0000-0002-7063-6026</orcidid><orcidid>https://orcid.org/0000-0003-2374-4187</orcidid><orcidid>https://orcid.org/0000-0002-7254-8249</orcidid><orcidid>https://orcid.org/0000-0001-8952-0659</orcidid><orcidid>https://orcid.org/0000-0001-5842-0233</orcidid><orcidid>https://orcid.org/0000-0001-7069-8238</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1573-2630 |
| ispartof | International ophthalmology, 2022-11, Vol.42 (11), p.3333-3343 |
| issn | 1573-2630 0165-5701 1573-2630 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Biomarkers Correlation Cross-Sectional Studies Defects Diabetes Diabetes Mellitus Diabetic retinopathy Diabetic Retinopathy - complications Diabetic Retinopathy - diagnosis Edema Glomerular filtration rate Humans Kidney diseases Macular Edema - complications Macular Edema - etiology Medical records Medicine Medicine & Public Health Morphology Ophthalmology Optical Coherence Tomography Original Paper Patients Renal Insufficiency, Chronic - complications Retinopathy Retrospective Studies Statistical analysis Tomography Tomography, Optical Coherence - methods |
| title | Correlating the patterns of diabetic macular edema, optical coherence tomography biomarkers and grade of diabetic retinopathy with stage of renal disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T11%3A52%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Correlating%20the%20patterns%20of%20diabetic%20macular%20edema,%20optical%20coherence%20tomography%20biomarkers%20and%20grade%20of%20diabetic%20retinopathy%20with%20stage%20of%20renal%20disease&rft.jtitle=International%20ophthalmology&rft.au=Agarwal,%20Manisha&rft.aucorp=India%20Retinal%20Disease%20Study%20group&rft.date=2022-11-01&rft.volume=42&rft.issue=11&rft.spage=3333&rft.epage=3343&rft.pages=3333-3343&rft.issn=1573-2630&rft.eissn=1573-2630&rft_id=info:doi/10.1007/s10792-022-02332-3&rft_dat=%3Cproquest_cross%3E2671267211%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2727283701&rft_id=info:pmid/35633427&rfr_iscdi=true |