Ruthenium-Catalyzed Divergent Acceptorless Dehydrogenative Coupling of 1,3-Diols with Arylhydrazines: Synthesis of Pyrazoles and 2‑Pyrazolines

Ruthenium-Catalyzed Divergent Acceptorless Dehydrogenative Coupling of 1,3-Diols with Arylhydrazines: Synthesis of Pyrazoles and 2‑Pyrazolines

Herein, the divergent transformations of 1,3-diols with arylhydrazines via acceptorless dehydrogenative coupling reactions to selectively synthesize pyrazoles and 2-pyrazolines were reported, which were based on Ru3(CO)12/NHC-phosphine-phosphine catalytic systems. The reactions featured low catalyst...

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Veröffentlicht in:Organic letters 2022-06, Vol.24 (21), p.3878-3883
Hauptverfasser: Zheng, Yanling, Long, Yang, Gong, Huihua, Xu, Jiaqi, Zhang, Chunchun, Fu, Haiyan, Zheng, Xueli, Chen, Hua, Li, Ruixiang
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container_end_page 3883
container_issue 21
container_start_page 3878
container_title Organic letters
container_volume 24
creator Zheng, Yanling
Long, Yang
Gong, Huihua
Xu, Jiaqi
Zhang, Chunchun
Fu, Haiyan
Zheng, Xueli
Chen, Hua
Li, Ruixiang
description Herein, the divergent transformations of 1,3-diols with arylhydrazines via acceptorless dehydrogenative coupling reactions to selectively synthesize pyrazoles and 2-pyrazolines were reported, which were based on Ru3(CO)12/NHC-phosphine-phosphine catalytic systems. The reactions featured low catalyst loading, high selectivity, wide substrate scope, and good yields, with only water and hydrogen gas (H2) as the byproducts.
doi_str_mv 10.1021/acs.orglett.2c01497
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title Ruthenium-Catalyzed Divergent Acceptorless Dehydrogenative Coupling of 1,3-Diols with Arylhydrazines: Synthesis of Pyrazoles and 2‑Pyrazolines
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