Induction of ferroptosis selectively eliminates senescent tubular cells

The accumulation of senescent cells is an important contributor to kidney aging, chronic renal disease, and poor outcome after kidney transplantation. Approaches to eliminate senescent cells with senolytic compounds have been proposed as novel strategies to improve marginal organs. While most existi...

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Veröffentlicht in:	American journal of transplantation 2022-09, Vol.22 (9), p.2158-2168
Hauptverfasser:	Liao, Chieh M., Wulfmeyer, Vera C., Chen, Rongjun, Erlangga, Zulrahman, Sinning, Julius, Mässenhausen, Anne, Sörensen‐Zender, Inga, Beer, Kristina, Vietinghoff, Sibylle, Haller, Hermann, Linkermann, Andreas, Melk, Anette, Schmitt, Roland
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Apoptosis Cell death Epithelial Cells Ferroptosis Glutathione peroxidase gpx4 Inflammation Kidney transplantation Kidney transplants Kidneys Lipoxygenase Mice organ perfusion and preservation Senescence senolysis senotherapy solid organ transplantation Transplants & implants
Online-Zugang:	Volltext
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