Molecular Evolution and Epidemiology of Parechovirus-A3 in Japan, 1997–2019
Abstract Parechovirus-A3 (PeV-A3), first reported in 2004 in Japan, is an emerging pathogen that causes sepsis and meningoencephalitis in neonates and young infants. Although PeV-A3 has been identified worldwide, its epidemiological characteristics differ by region. To investigate the molecular evol...
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| Veröffentlicht in: | The Journal of infectious diseases 2023-01, Vol.227 (2), p.288-294 |
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| creator | Aizawa, Yuta Kasamatsu, Takuhiro Nagasawa, Koo Watanabe, Kanako Saitoh, Akihiko |
| description | Abstract
Parechovirus-A3 (PeV-A3), first reported in 2004 in Japan, is an emerging pathogen that causes sepsis and meningoencephalitis in neonates and young infants. Although PeV-A3 has been identified worldwide, its epidemiological characteristics differ by region. To investigate the molecular evolution and epidemiology of PeV-A3, we performed genetic analyses of 131 PeV-A3 strains from the years 1997–2019 in Niigata, Japan. During 2016–2019, annual numbers remained steady, in contrast to the PeV-A3 epidemic interval of every 2–3 years that was observed in Japan from 2006. Bayesian evolutionary analysis of the complete viral protein 1 region revealed alternate dominant clusters during years of PeV-A3 epidemics. The branch including the oldest and first isolated PeV-A3 strains in Japan has been disrupted since 2001. The year of PeV-A3 emergence was estimated to be 1991. Continuous surveillance with genetic analyses of different regions will improve understanding of PeV-A3 epidemiology worldwide.
Bayesian evolutionary analysis revealed alternate dominant clusters in the epidemic years of parechovirus-A3 infection, and disruption of the oldest and first isolated strains in Japan. |
| doi_str_mv | 10.1093/infdis/jiac213 |
| format | Article |
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Parechovirus-A3 (PeV-A3), first reported in 2004 in Japan, is an emerging pathogen that causes sepsis and meningoencephalitis in neonates and young infants. Although PeV-A3 has been identified worldwide, its epidemiological characteristics differ by region. To investigate the molecular evolution and epidemiology of PeV-A3, we performed genetic analyses of 131 PeV-A3 strains from the years 1997–2019 in Niigata, Japan. During 2016–2019, annual numbers remained steady, in contrast to the PeV-A3 epidemic interval of every 2–3 years that was observed in Japan from 2006. Bayesian evolutionary analysis of the complete viral protein 1 region revealed alternate dominant clusters during years of PeV-A3 epidemics. The branch including the oldest and first isolated PeV-A3 strains in Japan has been disrupted since 2001. The year of PeV-A3 emergence was estimated to be 1991. Continuous surveillance with genetic analyses of different regions will improve understanding of PeV-A3 epidemiology worldwide.
Bayesian evolutionary analysis revealed alternate dominant clusters in the epidemic years of parechovirus-A3 infection, and disruption of the oldest and first isolated strains in Japan.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jiac213</identifier><identifier>PMID: 35608411</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Bayes Theorem ; Evolution, Molecular ; Humans ; Infant ; Infant, Newborn ; Japan - epidemiology ; Parechovirus - genetics ; Picornaviridae Infections - epidemiology</subject><ispartof>The Journal of infectious diseases, 2023-01, Vol.227 (2), p.288-294</ispartof><rights>The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2022</rights><rights>The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c395t-3f31576dda73062722223a606584379f07768f3695611de3f7e1db2ed74bc38f3</citedby><cites>FETCH-LOGICAL-c395t-3f31576dda73062722223a606584379f07768f3695611de3f7e1db2ed74bc38f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35608411$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aizawa, Yuta</creatorcontrib><creatorcontrib>Kasamatsu, Takuhiro</creatorcontrib><creatorcontrib>Nagasawa, Koo</creatorcontrib><creatorcontrib>Watanabe, Kanako</creatorcontrib><creatorcontrib>Saitoh, Akihiko</creatorcontrib><title>Molecular Evolution and Epidemiology of Parechovirus-A3 in Japan, 1997–2019</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Abstract
Parechovirus-A3 (PeV-A3), first reported in 2004 in Japan, is an emerging pathogen that causes sepsis and meningoencephalitis in neonates and young infants. Although PeV-A3 has been identified worldwide, its epidemiological characteristics differ by region. To investigate the molecular evolution and epidemiology of PeV-A3, we performed genetic analyses of 131 PeV-A3 strains from the years 1997–2019 in Niigata, Japan. During 2016–2019, annual numbers remained steady, in contrast to the PeV-A3 epidemic interval of every 2–3 years that was observed in Japan from 2006. Bayesian evolutionary analysis of the complete viral protein 1 region revealed alternate dominant clusters during years of PeV-A3 epidemics. The branch including the oldest and first isolated PeV-A3 strains in Japan has been disrupted since 2001. The year of PeV-A3 emergence was estimated to be 1991. Continuous surveillance with genetic analyses of different regions will improve understanding of PeV-A3 epidemiology worldwide.
Bayesian evolutionary analysis revealed alternate dominant clusters in the epidemic years of parechovirus-A3 infection, and disruption of the oldest and first isolated strains in Japan.</description><subject>Bayes Theorem</subject><subject>Evolution, Molecular</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Japan - epidemiology</subject><subject>Parechovirus - genetics</subject><subject>Picornaviridae Infections - epidemiology</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1PwzAQQC0EoqWwMiKPIJHWZyd2PFZV-VIrGGCO3NgGV0kc4qZSN_4D_5BfQlAKK7fccO_e8BA6BzIGItnEVVa7MFk7lVNgB2gICRMR58AO0ZAQSiNIpRygkxDWhJCYcXGMBizhJI0Bhmi59IXJ20I1eL71RbtxvsKq0nheO21K5wv_usPe4ifVmPzNb13ThmjKsKvwg6pVdY1BSvH18UkJyFN0ZFURzNl-j9DLzfx5dhctHm_vZ9NFlDOZbCJmGSSCa60EI5wK2g1TnPAkjZmQlgjBU8u4TDiANswKA3pFjRbxKmfdZYQue2_d-PfWhE1WupCbolCV8W3IKOepBJAp6dBxj-aND6ExNqsbV6pmlwHJfhJmfcJsn7B7uNi721Vp9B_-26wDrnrAt_V_sm9Ry3rQ</recordid><startdate>20230111</startdate><enddate>20230111</enddate><creator>Aizawa, Yuta</creator><creator>Kasamatsu, Takuhiro</creator><creator>Nagasawa, Koo</creator><creator>Watanabe, Kanako</creator><creator>Saitoh, Akihiko</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230111</creationdate><title>Molecular Evolution and Epidemiology of Parechovirus-A3 in Japan, 1997–2019</title><author>Aizawa, Yuta ; Kasamatsu, Takuhiro ; Nagasawa, Koo ; Watanabe, Kanako ; Saitoh, Akihiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c395t-3f31576dda73062722223a606584379f07768f3695611de3f7e1db2ed74bc38f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Bayes Theorem</topic><topic>Evolution, Molecular</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Japan - epidemiology</topic><topic>Parechovirus - genetics</topic><topic>Picornaviridae Infections - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aizawa, Yuta</creatorcontrib><creatorcontrib>Kasamatsu, Takuhiro</creatorcontrib><creatorcontrib>Nagasawa, Koo</creatorcontrib><creatorcontrib>Watanabe, Kanako</creatorcontrib><creatorcontrib>Saitoh, Akihiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aizawa, Yuta</au><au>Kasamatsu, Takuhiro</au><au>Nagasawa, Koo</au><au>Watanabe, Kanako</au><au>Saitoh, Akihiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular Evolution and Epidemiology of Parechovirus-A3 in Japan, 1997–2019</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>2023-01-11</date><risdate>2023</risdate><volume>227</volume><issue>2</issue><spage>288</spage><epage>294</epage><pages>288-294</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>Abstract
Parechovirus-A3 (PeV-A3), first reported in 2004 in Japan, is an emerging pathogen that causes sepsis and meningoencephalitis in neonates and young infants. Although PeV-A3 has been identified worldwide, its epidemiological characteristics differ by region. To investigate the molecular evolution and epidemiology of PeV-A3, we performed genetic analyses of 131 PeV-A3 strains from the years 1997–2019 in Niigata, Japan. During 2016–2019, annual numbers remained steady, in contrast to the PeV-A3 epidemic interval of every 2–3 years that was observed in Japan from 2006. Bayesian evolutionary analysis of the complete viral protein 1 region revealed alternate dominant clusters during years of PeV-A3 epidemics. The branch including the oldest and first isolated PeV-A3 strains in Japan has been disrupted since 2001. The year of PeV-A3 emergence was estimated to be 1991. Continuous surveillance with genetic analyses of different regions will improve understanding of PeV-A3 epidemiology worldwide.
Bayesian evolutionary analysis revealed alternate dominant clusters in the epidemic years of parechovirus-A3 infection, and disruption of the oldest and first isolated strains in Japan.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>35608411</pmid><doi>10.1093/infdis/jiac213</doi><tpages>7</tpages></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Bayes Theorem Evolution, Molecular Humans Infant Infant, Newborn Japan - epidemiology Parechovirus - genetics Picornaviridae Infections - epidemiology |
| title | Molecular Evolution and Epidemiology of Parechovirus-A3 in Japan, 1997–2019 |
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