CNS-associated T-lymphocytes in a mouse model of Hereditary Spastic Paraplegia type 11 (SPG11) are therapeutic targets for established immunomodulators

Pharmacological targeting of neuroinflammation in distinct models of genetically mediated disorders of the central nervous system (CNS) has been shown to attenuate disease outcome significantly. These include mouse models mimicking distinct subtypes of neuronal ceroid lipofuscinoses (NCL, CLN diseas...

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Veröffentlicht in:	Experimental neurology 2022-09, Vol.355, p.114119-114119, Article 114119
Hauptverfasser:	Hörner, Michaela, Groh, Janos, Klein, Dennis, Ilg, Winfried, Schöls, Ludger, Dos Santos, Sara, Bergmann, Anna, Klebe, Stephan, Cauhape, Margaux, Branchu, Julien, El Hachimi, Khalid Hamid, Stevanin, Giovanni, Darios, Frédéric, Martini, Rudolf
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immune system Axonopathy Gait abnormalities Microglia Neurodegeneration Neuroinflammation Repurposing drugs
Online-Zugang:	Volltext
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