Impaired glucose metabolism underlies articular cartilage degeneration in osteoarthritis

Osteoarthritis (OA) is the leading joint disease characterized by cartilage destruction and loss of mobility. Accumulating evidence indicates that the incidence and severity of OA increases with diabetes, implicating systemic glucose metabolism in joint health. However, a definitive link between cel...

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Veröffentlicht in:	The FASEB journal 2022-06, Vol.36 (6), p.e22377-n/a
Hauptverfasser:	Li, Ke, Ji, Xing, Seeley, Rebecca, Lee, Wen‐Chih, Shi, Yu, Song, Fangfang, Liao, Xueyang, Song, Chao, Huang, Xiaobin, Rux, Danielle, Cao, Ju, Luo, Xiaoji, Anderson, Steven M., Huang, Wei, Long, Fanxin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals articular cartilage Cartilage, Articular - metabolism Chondrocytes - metabolism diabetes Diabetes Mellitus, Experimental - metabolism Disease Models, Animal Glucose - metabolism Glucose Transporter Type 1 - genetics Glucose Transporter Type 1 - metabolism Glut1 glycolysis Mice osteoarthritis Osteoarthritis - metabolism
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