An in vitro model of fibrosis using crosslinked native extracellular matrix-derived hydrogels to modulate biomechanics without changing composition

Extracellular matrix (ECM) is a dynamic network of proteins, proteoglycans and glycosaminoglycans, providing structure to the tissue and biochemical and biomechanical instructions to the resident cells. In fibrosis, the composition and the organization of the ECM are altered, and these changes influ...

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Veröffentlicht in:	Acta biomaterialia 2022-07, Vol.147, p.50-62
Hauptverfasser:	Nizamoglu, Mehmet, de Hilster, Roderick H.J., Zhao, Fenghua, Sharma, Prashant K., Borghuis, Theo, Harmsen, Martin C., Burgess, Janette K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Crosslinking ECM hydrogel Extracellular matrix Fibrosis Lung Maxwell model Ruthenium Viscoelasticity
Online-Zugang:	Volltext
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