Novel linezolid-based oxazolidinones as potent anticandidiasis and antitubercular agents

[Display omitted] •Novel series of linezolid-based oxazolidinones were designed and synthesized by selected modifications.•Potent anticandidiasis activity exhibited by oxazolidinone (2, 3a) against 14 strains of C.albicans.•Demonstration of mechanism of action by the inhibition of ergosterol biosynt...

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Veröffentlicht in:	Bioorganic chemistry 2022-09, Vol.126, p.105869-105869, Article 105869
Hauptverfasser:	Faazil, Shaik, Malik, M. Shaheer, Ahmed, Saleh A., Alsantali, Reem I., Yedla, Poornachandra, Alsharif, Meshari A., Shaikh, Iqbal N., Kamal, Ahmed
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticandidiasis Antifungal Antitubercular Molecular dynamics Oxazolidinone Pharmacophore modeling
Online-Zugang:	Volltext
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