The impact of human leukocyte antigen mismatch on recipient outcomes in living‐donor liver transplantation
Donor–recipient human leukocyte antigen (HLA) compatibility has not been considered to significantly affect liver transplantation (LT) outcomes; however, its significance in living‐donor LT (LDLT), which is mostly performed between blood relatives, remains unclear. This retrospective cohort study in...
Gespeichert in:
| Veröffentlicht in: | Liver transplantation 2022-10, Vol.28 (10), p.1588-1602 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1602 |
|---|---|
| container_issue | 10 |
| container_start_page | 1588 |
| container_title | Liver transplantation |
| container_volume | 28 |
| creator | Tajima, Tetsuya Hata, Koichiro Kusakabe, Jiro Miyauchi, Hidetaka Yurugi, Kimiko Hishida, Rie Ogawa, Eri Okamoto, Tatsuya Sonoda, Mari Kageyama, Shoichi Zhao, Xiangdong Ito, Takashi Seo, Satoru Okajima, Hideaki Nagao, Miki Haga, Hironori Uemoto, Shinji Hatano, Etsuro |
| description | Donor–recipient human leukocyte antigen (HLA) compatibility has not been considered to significantly affect liver transplantation (LT) outcomes; however, its significance in living‐donor LT (LDLT), which is mostly performed between blood relatives, remains unclear. This retrospective cohort study included 1954 LDLTs at our institution (1990–2020). The primary and secondary endpoints were recipient survival and the incidence of T cell–mediated rejection (TCMR) after LDLT, respectively, according to the number of HLA mismatches at all five loci: HLA‐A, HLA‐B, HLA‐C, HLA‐DR, and HLA‐DQ. Subgroup analyses were also performed in between‐siblings that characteristically have widely distributed 0–10 HLA mismatches. A total of 1304 cases of primary LDLTs were finally enrolled, including 631 adults (recipient age at LT ≥18 years) and 673 children ( |
| doi_str_mv | 10.1002/lt.26511 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2668218613</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2715460186</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4271-239be7a2b0137212e9902163114923317bcec431c45a144b03ff61ec8bc9b9e83</originalsourceid><addsrcrecordid>eNp1kcFO3DAQhq2qqFCo1CeoLPXSS8BjJ87miFBpkVbispwtxzvZ9Taxg-2A9tZH4Bn7JDXsAhISp5mRvvn0a4aQr8BOgTF-1qdTLiuAD-QIKl4XsqzFx5deVofkc4wbxgCqhn0ih6KSTFRcHpF-sUZqh1GbRH1H19OgHe1x-uPNNiHVLtkVOjrYOOhk1tQ7GtDY0aLLC1MyfsBIbd6xd9at_v19WHrnw-OIgaagXRz7bNHJendCDjrdR_yyr8fk5vLn4uJ3Mb_-dXVxPi9MyWsouGharDVvGYiaA8emYRykACgbLgTUrUFTCjBlpaEsWya6TgKaWWuatsGZOCY_dt4x-NsJY1I5v8E-B0E_RcWlnHGYSRAZ_f4G3fgpuJxO5ShVKVnmXoUm-BgDdmoMdtBhq4Cpxw-oPqmnD2T02144tQMuX8Dnk2eg2AH3tsftuyI1X-yE_wGj8I-k</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2715460186</pqid></control><display><type>article</type><title>The impact of human leukocyte antigen mismatch on recipient outcomes in living‐donor liver transplantation</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Alma/SFX Local Collection</source><creator>Tajima, Tetsuya ; Hata, Koichiro ; Kusakabe, Jiro ; Miyauchi, Hidetaka ; Yurugi, Kimiko ; Hishida, Rie ; Ogawa, Eri ; Okamoto, Tatsuya ; Sonoda, Mari ; Kageyama, Shoichi ; Zhao, Xiangdong ; Ito, Takashi ; Seo, Satoru ; Okajima, Hideaki ; Nagao, Miki ; Haga, Hironori ; Uemoto, Shinji ; Hatano, Etsuro</creator><creatorcontrib>Tajima, Tetsuya ; Hata, Koichiro ; Kusakabe, Jiro ; Miyauchi, Hidetaka ; Yurugi, Kimiko ; Hishida, Rie ; Ogawa, Eri ; Okamoto, Tatsuya ; Sonoda, Mari ; Kageyama, Shoichi ; Zhao, Xiangdong ; Ito, Takashi ; Seo, Satoru ; Okajima, Hideaki ; Nagao, Miki ; Haga, Hironori ; Uemoto, Shinji ; Hatano, Etsuro</creatorcontrib><description>Donor–recipient human leukocyte antigen (HLA) compatibility has not been considered to significantly affect liver transplantation (LT) outcomes; however, its significance in living‐donor LT (LDLT), which is mostly performed between blood relatives, remains unclear. This retrospective cohort study included 1954 LDLTs at our institution (1990–2020). The primary and secondary endpoints were recipient survival and the incidence of T cell–mediated rejection (TCMR) after LDLT, respectively, according to the number of HLA mismatches at all five loci: HLA‐A, HLA‐B, HLA‐C, HLA‐DR, and HLA‐DQ. Subgroup analyses were also performed in between‐siblings that characteristically have widely distributed 0–10 HLA mismatches. A total of 1304 cases of primary LDLTs were finally enrolled, including 631 adults (recipient age at LT ≥18 years) and 673 children (<18 years). In adult‐to‐adult LDLT, the more HLA mismatches at each locus, the significantly worse the recipient survival was (p = 0.03, 0.01, 0.03, 0.001, and <0.001 for HLA‐A, HLA‐B, HLA‐C, HLA‐DR, and HLA‐DQ, respectively). This trend was more pronounced when multiple loci were combined (all p < 0.001 for A + B + DR, A + B + C, DR + DQ, and A + B + C + DR + DQ). Notably, a total of three or more HLA‐B + DR mismatches was an independent risk factor for both TCMR (hazard ratio [HR] 2.66, 95% confidence interval [CI] 1.21–5.87; p = 0.02) and recipient survival (HR 2.44, 95% CI 1.11–5.35; p = 0.03) in between‐siblings. By contrast, HLA mismatch did not affect pediatric LDLT outcomes at any locus or in any combinations; however, it should be noted that all donor–recipient relationships are parent‐to‐child that characteristically possesses one or less HLA mismatch at each locus and maximally five or less mismatches in total. In conclusion, HLA mismatch significantly affects not only TCMR development but also recipient survival in adult LDLT, but not in children.</description><identifier>ISSN: 1527-6465</identifier><identifier>EISSN: 1527-6473</identifier><identifier>DOI: 10.1002/lt.26511</identifier><identifier>PMID: 35603526</identifier><language>eng</language><publisher>United States: Wolters Kluwer Health, Inc</publisher><subject>Adult ; Antigens ; Child ; Graft rejection ; Graft Rejection - epidemiology ; Graft Survival ; Histocompatibility antigen HLA ; Histocompatibility Testing ; HLA Antigens ; HLA-A Antigens ; HLA-B Antigens ; HLA-C Antigens ; HLA-DQ Antigens ; HLA-DR Antigens ; Humans ; Liver transplantation ; Liver Transplantation - adverse effects ; Liver transplants ; Living Donors ; Lymphocytes T ; Pediatrics ; Retrospective Studies ; Risk factors ; Siblings</subject><ispartof>Liver transplantation, 2022-10, Vol.28 (10), p.1588-1602</ispartof><rights>2022 The Authors. published by Wiley Periodicals LLC on behalf of American Association for the Study of Liver Diseases.</rights><rights>2022 The Authors. Liver Transplantation published by Wiley Periodicals LLC on behalf of American Association for the Study of Liver Diseases.</rights><rights>2022. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4271-239be7a2b0137212e9902163114923317bcec431c45a144b03ff61ec8bc9b9e83</citedby><cites>FETCH-LOGICAL-c4271-239be7a2b0137212e9902163114923317bcec431c45a144b03ff61ec8bc9b9e83</cites><orcidid>0000-0003-4322-9561 ; 0000-0002-3609-6396 ; 0000-0003-0126-9346 ; 0000-0003-0961-7130 ; 0000-0002-4043-1070 ; 0000-0002-5892-8317 ; 0000-0002-6538-7408 ; 0000-0001-9539-8098 ; 0000-0002-8552-3147 ; 0000-0002-8886-6145 ; 0000-0003-3407-1918</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Flt.26511$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Flt.26511$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35603526$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tajima, Tetsuya</creatorcontrib><creatorcontrib>Hata, Koichiro</creatorcontrib><creatorcontrib>Kusakabe, Jiro</creatorcontrib><creatorcontrib>Miyauchi, Hidetaka</creatorcontrib><creatorcontrib>Yurugi, Kimiko</creatorcontrib><creatorcontrib>Hishida, Rie</creatorcontrib><creatorcontrib>Ogawa, Eri</creatorcontrib><creatorcontrib>Okamoto, Tatsuya</creatorcontrib><creatorcontrib>Sonoda, Mari</creatorcontrib><creatorcontrib>Kageyama, Shoichi</creatorcontrib><creatorcontrib>Zhao, Xiangdong</creatorcontrib><creatorcontrib>Ito, Takashi</creatorcontrib><creatorcontrib>Seo, Satoru</creatorcontrib><creatorcontrib>Okajima, Hideaki</creatorcontrib><creatorcontrib>Nagao, Miki</creatorcontrib><creatorcontrib>Haga, Hironori</creatorcontrib><creatorcontrib>Uemoto, Shinji</creatorcontrib><creatorcontrib>Hatano, Etsuro</creatorcontrib><title>The impact of human leukocyte antigen mismatch on recipient outcomes in living‐donor liver transplantation</title><title>Liver transplantation</title><addtitle>Liver Transpl</addtitle><description>Donor–recipient human leukocyte antigen (HLA) compatibility has not been considered to significantly affect liver transplantation (LT) outcomes; however, its significance in living‐donor LT (LDLT), which is mostly performed between blood relatives, remains unclear. This retrospective cohort study included 1954 LDLTs at our institution (1990–2020). The primary and secondary endpoints were recipient survival and the incidence of T cell–mediated rejection (TCMR) after LDLT, respectively, according to the number of HLA mismatches at all five loci: HLA‐A, HLA‐B, HLA‐C, HLA‐DR, and HLA‐DQ. Subgroup analyses were also performed in between‐siblings that characteristically have widely distributed 0–10 HLA mismatches. A total of 1304 cases of primary LDLTs were finally enrolled, including 631 adults (recipient age at LT ≥18 years) and 673 children (<18 years). In adult‐to‐adult LDLT, the more HLA mismatches at each locus, the significantly worse the recipient survival was (p = 0.03, 0.01, 0.03, 0.001, and <0.001 for HLA‐A, HLA‐B, HLA‐C, HLA‐DR, and HLA‐DQ, respectively). This trend was more pronounced when multiple loci were combined (all p < 0.001 for A + B + DR, A + B + C, DR + DQ, and A + B + C + DR + DQ). Notably, a total of three or more HLA‐B + DR mismatches was an independent risk factor for both TCMR (hazard ratio [HR] 2.66, 95% confidence interval [CI] 1.21–5.87; p = 0.02) and recipient survival (HR 2.44, 95% CI 1.11–5.35; p = 0.03) in between‐siblings. By contrast, HLA mismatch did not affect pediatric LDLT outcomes at any locus or in any combinations; however, it should be noted that all donor–recipient relationships are parent‐to‐child that characteristically possesses one or less HLA mismatch at each locus and maximally five or less mismatches in total. In conclusion, HLA mismatch significantly affects not only TCMR development but also recipient survival in adult LDLT, but not in children.</description><subject>Adult</subject><subject>Antigens</subject><subject>Child</subject><subject>Graft rejection</subject><subject>Graft Rejection - epidemiology</subject><subject>Graft Survival</subject><subject>Histocompatibility antigen HLA</subject><subject>Histocompatibility Testing</subject><subject>HLA Antigens</subject><subject>HLA-A Antigens</subject><subject>HLA-B Antigens</subject><subject>HLA-C Antigens</subject><subject>HLA-DQ Antigens</subject><subject>HLA-DR Antigens</subject><subject>Humans</subject><subject>Liver transplantation</subject><subject>Liver Transplantation - adverse effects</subject><subject>Liver transplants</subject><subject>Living Donors</subject><subject>Lymphocytes T</subject><subject>Pediatrics</subject><subject>Retrospective Studies</subject><subject>Risk factors</subject><subject>Siblings</subject><issn>1527-6465</issn><issn>1527-6473</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp1kcFO3DAQhq2qqFCo1CeoLPXSS8BjJ87miFBpkVbispwtxzvZ9Taxg-2A9tZH4Bn7JDXsAhISp5mRvvn0a4aQr8BOgTF-1qdTLiuAD-QIKl4XsqzFx5deVofkc4wbxgCqhn0ih6KSTFRcHpF-sUZqh1GbRH1H19OgHe1x-uPNNiHVLtkVOjrYOOhk1tQ7GtDY0aLLC1MyfsBIbd6xd9at_v19WHrnw-OIgaagXRz7bNHJendCDjrdR_yyr8fk5vLn4uJ3Mb_-dXVxPi9MyWsouGharDVvGYiaA8emYRykACgbLgTUrUFTCjBlpaEsWya6TgKaWWuatsGZOCY_dt4x-NsJY1I5v8E-B0E_RcWlnHGYSRAZ_f4G3fgpuJxO5ShVKVnmXoUm-BgDdmoMdtBhq4Cpxw-oPqmnD2T02144tQMuX8Dnk2eg2AH3tsftuyI1X-yE_wGj8I-k</recordid><startdate>202210</startdate><enddate>202210</enddate><creator>Tajima, Tetsuya</creator><creator>Hata, Koichiro</creator><creator>Kusakabe, Jiro</creator><creator>Miyauchi, Hidetaka</creator><creator>Yurugi, Kimiko</creator><creator>Hishida, Rie</creator><creator>Ogawa, Eri</creator><creator>Okamoto, Tatsuya</creator><creator>Sonoda, Mari</creator><creator>Kageyama, Shoichi</creator><creator>Zhao, Xiangdong</creator><creator>Ito, Takashi</creator><creator>Seo, Satoru</creator><creator>Okajima, Hideaki</creator><creator>Nagao, Miki</creator><creator>Haga, Hironori</creator><creator>Uemoto, Shinji</creator><creator>Hatano, Etsuro</creator><general>Wolters Kluwer Health, Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4322-9561</orcidid><orcidid>https://orcid.org/0000-0002-3609-6396</orcidid><orcidid>https://orcid.org/0000-0003-0126-9346</orcidid><orcidid>https://orcid.org/0000-0003-0961-7130</orcidid><orcidid>https://orcid.org/0000-0002-4043-1070</orcidid><orcidid>https://orcid.org/0000-0002-5892-8317</orcidid><orcidid>https://orcid.org/0000-0002-6538-7408</orcidid><orcidid>https://orcid.org/0000-0001-9539-8098</orcidid><orcidid>https://orcid.org/0000-0002-8552-3147</orcidid><orcidid>https://orcid.org/0000-0002-8886-6145</orcidid><orcidid>https://orcid.org/0000-0003-3407-1918</orcidid></search><sort><creationdate>202210</creationdate><title>The impact of human leukocyte antigen mismatch on recipient outcomes in living‐donor liver transplantation</title><author>Tajima, Tetsuya ; Hata, Koichiro ; Kusakabe, Jiro ; Miyauchi, Hidetaka ; Yurugi, Kimiko ; Hishida, Rie ; Ogawa, Eri ; Okamoto, Tatsuya ; Sonoda, Mari ; Kageyama, Shoichi ; Zhao, Xiangdong ; Ito, Takashi ; Seo, Satoru ; Okajima, Hideaki ; Nagao, Miki ; Haga, Hironori ; Uemoto, Shinji ; Hatano, Etsuro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4271-239be7a2b0137212e9902163114923317bcec431c45a144b03ff61ec8bc9b9e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>Antigens</topic><topic>Child</topic><topic>Graft rejection</topic><topic>Graft Rejection - epidemiology</topic><topic>Graft Survival</topic><topic>Histocompatibility antigen HLA</topic><topic>Histocompatibility Testing</topic><topic>HLA Antigens</topic><topic>HLA-A Antigens</topic><topic>HLA-B Antigens</topic><topic>HLA-C Antigens</topic><topic>HLA-DQ Antigens</topic><topic>HLA-DR Antigens</topic><topic>Humans</topic><topic>Liver transplantation</topic><topic>Liver Transplantation - adverse effects</topic><topic>Liver transplants</topic><topic>Living Donors</topic><topic>Lymphocytes T</topic><topic>Pediatrics</topic><topic>Retrospective Studies</topic><topic>Risk factors</topic><topic>Siblings</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tajima, Tetsuya</creatorcontrib><creatorcontrib>Hata, Koichiro</creatorcontrib><creatorcontrib>Kusakabe, Jiro</creatorcontrib><creatorcontrib>Miyauchi, Hidetaka</creatorcontrib><creatorcontrib>Yurugi, Kimiko</creatorcontrib><creatorcontrib>Hishida, Rie</creatorcontrib><creatorcontrib>Ogawa, Eri</creatorcontrib><creatorcontrib>Okamoto, Tatsuya</creatorcontrib><creatorcontrib>Sonoda, Mari</creatorcontrib><creatorcontrib>Kageyama, Shoichi</creatorcontrib><creatorcontrib>Zhao, Xiangdong</creatorcontrib><creatorcontrib>Ito, Takashi</creatorcontrib><creatorcontrib>Seo, Satoru</creatorcontrib><creatorcontrib>Okajima, Hideaki</creatorcontrib><creatorcontrib>Nagao, Miki</creatorcontrib><creatorcontrib>Haga, Hironori</creatorcontrib><creatorcontrib>Uemoto, Shinji</creatorcontrib><creatorcontrib>Hatano, Etsuro</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Liver transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tajima, Tetsuya</au><au>Hata, Koichiro</au><au>Kusakabe, Jiro</au><au>Miyauchi, Hidetaka</au><au>Yurugi, Kimiko</au><au>Hishida, Rie</au><au>Ogawa, Eri</au><au>Okamoto, Tatsuya</au><au>Sonoda, Mari</au><au>Kageyama, Shoichi</au><au>Zhao, Xiangdong</au><au>Ito, Takashi</au><au>Seo, Satoru</au><au>Okajima, Hideaki</au><au>Nagao, Miki</au><au>Haga, Hironori</au><au>Uemoto, Shinji</au><au>Hatano, Etsuro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The impact of human leukocyte antigen mismatch on recipient outcomes in living‐donor liver transplantation</atitle><jtitle>Liver transplantation</jtitle><addtitle>Liver Transpl</addtitle><date>2022-10</date><risdate>2022</risdate><volume>28</volume><issue>10</issue><spage>1588</spage><epage>1602</epage><pages>1588-1602</pages><issn>1527-6465</issn><eissn>1527-6473</eissn><abstract>Donor–recipient human leukocyte antigen (HLA) compatibility has not been considered to significantly affect liver transplantation (LT) outcomes; however, its significance in living‐donor LT (LDLT), which is mostly performed between blood relatives, remains unclear. This retrospective cohort study included 1954 LDLTs at our institution (1990–2020). The primary and secondary endpoints were recipient survival and the incidence of T cell–mediated rejection (TCMR) after LDLT, respectively, according to the number of HLA mismatches at all five loci: HLA‐A, HLA‐B, HLA‐C, HLA‐DR, and HLA‐DQ. Subgroup analyses were also performed in between‐siblings that characteristically have widely distributed 0–10 HLA mismatches. A total of 1304 cases of primary LDLTs were finally enrolled, including 631 adults (recipient age at LT ≥18 years) and 673 children (<18 years). In adult‐to‐adult LDLT, the more HLA mismatches at each locus, the significantly worse the recipient survival was (p = 0.03, 0.01, 0.03, 0.001, and <0.001 for HLA‐A, HLA‐B, HLA‐C, HLA‐DR, and HLA‐DQ, respectively). This trend was more pronounced when multiple loci were combined (all p < 0.001 for A + B + DR, A + B + C, DR + DQ, and A + B + C + DR + DQ). Notably, a total of three or more HLA‐B + DR mismatches was an independent risk factor for both TCMR (hazard ratio [HR] 2.66, 95% confidence interval [CI] 1.21–5.87; p = 0.02) and recipient survival (HR 2.44, 95% CI 1.11–5.35; p = 0.03) in between‐siblings. By contrast, HLA mismatch did not affect pediatric LDLT outcomes at any locus or in any combinations; however, it should be noted that all donor–recipient relationships are parent‐to‐child that characteristically possesses one or less HLA mismatch at each locus and maximally five or less mismatches in total. In conclusion, HLA mismatch significantly affects not only TCMR development but also recipient survival in adult LDLT, but not in children.</abstract><cop>United States</cop><pub>Wolters Kluwer Health, Inc</pub><pmid>35603526</pmid><doi>10.1002/lt.26511</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0003-4322-9561</orcidid><orcidid>https://orcid.org/0000-0002-3609-6396</orcidid><orcidid>https://orcid.org/0000-0003-0126-9346</orcidid><orcidid>https://orcid.org/0000-0003-0961-7130</orcidid><orcidid>https://orcid.org/0000-0002-4043-1070</orcidid><orcidid>https://orcid.org/0000-0002-5892-8317</orcidid><orcidid>https://orcid.org/0000-0002-6538-7408</orcidid><orcidid>https://orcid.org/0000-0001-9539-8098</orcidid><orcidid>https://orcid.org/0000-0002-8552-3147</orcidid><orcidid>https://orcid.org/0000-0002-8886-6145</orcidid><orcidid>https://orcid.org/0000-0003-3407-1918</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1527-6465 |
| ispartof | Liver transplantation, 2022-10, Vol.28 (10), p.1588-1602 |
| issn | 1527-6465 1527-6473 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2668218613 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Adult Antigens Child Graft rejection Graft Rejection - epidemiology Graft Survival Histocompatibility antigen HLA Histocompatibility Testing HLA Antigens HLA-A Antigens HLA-B Antigens HLA-C Antigens HLA-DQ Antigens HLA-DR Antigens Humans Liver transplantation Liver Transplantation - adverse effects Liver transplants Living Donors Lymphocytes T Pediatrics Retrospective Studies Risk factors Siblings |
| title | The impact of human leukocyte antigen mismatch on recipient outcomes in living‐donor liver transplantation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T08%3A30%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20impact%20of%20human%20leukocyte%20antigen%20mismatch%20on%20recipient%20outcomes%20in%20living%E2%80%90donor%20liver%20transplantation&rft.jtitle=Liver%20transplantation&rft.au=Tajima,%20Tetsuya&rft.date=2022-10&rft.volume=28&rft.issue=10&rft.spage=1588&rft.epage=1602&rft.pages=1588-1602&rft.issn=1527-6465&rft.eissn=1527-6473&rft_id=info:doi/10.1002/lt.26511&rft_dat=%3Cproquest_cross%3E2715460186%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2715460186&rft_id=info:pmid/35603526&rfr_iscdi=true |