Muscle-Derived Beige Adipose Precursors Secrete Promyogenic Exosomes That Treat Rotator Cuff Muscle Degeneration in Mice and Are Identified in Humans by Single-Cell RNA Sequencing

Background: Muscle atrophy, fibrosis, and fatty infiltration are common to a variety of sports-related and degenerative conditions and are thought to be irreversible. Fibroadipogenic progenitors (FAPs) are multipotent resident muscle stem cells with the capacity to differentiate into fibrogenic as w...

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Veröffentlicht in:	The American journal of sports medicine 2022-07, Vol.50 (8), p.2247-2257
Hauptverfasser:	Davies, Michael R., Garcia, Steven, Liu, Mengyao, Chi, Hannah, Kim, Hubert T., Raffai, Robert L., Liu, Xuhui, Feeley, Brian T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Atrophy Body fat Extracellular vesicles Fibroblasts Gene expression Rotator cuff Sports medicine
Online-Zugang:	Volltext
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