Mechanism of METTL3‐mediated m6A modification in depression‐induced cognitive deficits

Depressive disorder (DD) is associated with N6‐methyladenosine (m6A) hypermethylation. This study sought to explore the molecular mechanism of Methyltransferase‐like 3 (METTL3) in cognitive deficits of chronic unpredictable mild stress (CUMS)‐treated rats and provide novel targets for DD treatment....

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Veröffentlicht in:	American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2022-04, Vol.189 (3-4), p.86-99
Hauptverfasser:	Niu, Juan, Wang, Bailing, Wang, Tian, Zhou, Tiantian
Format:	Artikel
Sprache:	eng
Schlagworte:	Cognitive ability cognitive deficits depressive disorder Genetics Grb2 protein Hippocampus Methyltransferase METTL3 miRNA N6-methyladenosine RNA methylation Thymic hypoplasia Western blotting
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