Lifestyle Affects Amyloid Burden and Cognition Differently in Men and Women
Objective Evidence on associations of lifestyle factors with Alzheimer's pathology and cognition are ambiguous, potentially because they rarely addressed inter‐relationships of factors and sex effects. While considering these aspects, we examined the relationships of lifestyle factors with brai...
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| Veröffentlicht in: | Annals of neurology 2022-09, Vol.92 (3), p.451-463 |
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| container_title | Annals of neurology |
| container_volume | 92 |
| creator | Bachmann, Dario Roman, Zachary J. Buchmann, Andreas Zuber, Isabelle Studer, Sandro Saake, Antje Rauen, Katrin Gruber, Esmeralda Nitsch, Roger M. Hock, Christoph Gietl, Anton F. Treyer, Valerie |
| description | Objective
Evidence on associations of lifestyle factors with Alzheimer's pathology and cognition are ambiguous, potentially because they rarely addressed inter‐relationships of factors and sex effects. While considering these aspects, we examined the relationships of lifestyle factors with brain amyloid burden and cognition.
Methods
We studied 178 cognitively normal individuals (women, 49%; 65.0 [7.6] years) and 54 individuals with mild cognitive impairment (women, 35%; 71.3 [8.3] years) enrolled in a prospective study of volunteers who completed 18F‐Flutemetamol amyloid positron emission tomography. Using structural equation modeling, we examined associations between latent constructs representing metabolic/vascular risk, physical activity, and cognitive activity with global amyloid burden and cognitive performance. Furthermore, we investigated the influence of sex in this model.
Results
Overall, higher cognitive activity was associated with better cognitive performance and higher physical activity was associated with lower amyloid burden. The latter association was weakened to a nonsignificant level after excluding multivariate outliers. Examination of the moderating effect of sex in the model revealed an inverse association of metabolic/vascular risk with cognition in men, whereas in women metabolic/vascular risk trended toward increased amyloid burden. Furthermore, a significant inverse association between physical activity and amyloid burden was found only in men. Inheritance of an APOE4 allele was associated with higher amyloid burden only in women.
Interpretation
Sex modifies effects of certain lifestyle‐related factors on amyloid burden and cognition. Notably, our results suggest that the negative impact of metabolic/vascular risk influences the risk of cognitive decline and Alzheimer's disease through distinct paths in women and men. ANN NEUROL 2022;92:451–463 |
| doi_str_mv | 10.1002/ana.26417 |
| format | Article |
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Evidence on associations of lifestyle factors with Alzheimer's pathology and cognition are ambiguous, potentially because they rarely addressed inter‐relationships of factors and sex effects. While considering these aspects, we examined the relationships of lifestyle factors with brain amyloid burden and cognition.
Methods
We studied 178 cognitively normal individuals (women, 49%; 65.0 [7.6] years) and 54 individuals with mild cognitive impairment (women, 35%; 71.3 [8.3] years) enrolled in a prospective study of volunteers who completed 18F‐Flutemetamol amyloid positron emission tomography. Using structural equation modeling, we examined associations between latent constructs representing metabolic/vascular risk, physical activity, and cognitive activity with global amyloid burden and cognitive performance. Furthermore, we investigated the influence of sex in this model.
Results
Overall, higher cognitive activity was associated with better cognitive performance and higher physical activity was associated with lower amyloid burden. The latter association was weakened to a nonsignificant level after excluding multivariate outliers. Examination of the moderating effect of sex in the model revealed an inverse association of metabolic/vascular risk with cognition in men, whereas in women metabolic/vascular risk trended toward increased amyloid burden. Furthermore, a significant inverse association between physical activity and amyloid burden was found only in men. Inheritance of an APOE4 allele was associated with higher amyloid burden only in women.
Interpretation
Sex modifies effects of certain lifestyle‐related factors on amyloid burden and cognition. Notably, our results suggest that the negative impact of metabolic/vascular risk influences the risk of cognitive decline and Alzheimer's disease through distinct paths in women and men. ANN NEUROL 2022;92:451–463</description><identifier>ISSN: 0364-5134</identifier><identifier>EISSN: 1531-8249</identifier><identifier>DOI: 10.1002/ana.26417</identifier><identifier>PMID: 35598071</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Alzheimer's disease ; Cognition ; Cognition & reasoning ; Cognitive ability ; Emission analysis ; Heredity ; Lifestyles ; Men ; Metabolism ; Multivariate statistical analysis ; Neurodegenerative diseases ; Physical activity ; Positron emission ; Positron emission tomography ; Risk ; Sex ; Women</subject><ispartof>Annals of neurology, 2022-09, Vol.92 (3), p.451-463</ispartof><rights>2022 The Authors. published by Wiley Periodicals LLC on behalf of American Neurological Association.</rights><rights>This article is protected by copyright. All rights reserved.</rights><rights>2022. This article is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4427-4c873d2525cfe6f576bace1216e00eb3ade1b26aed21ebe49954b83a62c0f9383</citedby><cites>FETCH-LOGICAL-c4427-4c873d2525cfe6f576bace1216e00eb3ade1b26aed21ebe49954b83a62c0f9383</cites><orcidid>0000-0002-4584-3031 ; 0000-0001-8604-962X ; 0000-0002-2863-537X ; 0000-0003-4555-6697</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fana.26417$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fana.26417$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35598071$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bachmann, Dario</creatorcontrib><creatorcontrib>Roman, Zachary J.</creatorcontrib><creatorcontrib>Buchmann, Andreas</creatorcontrib><creatorcontrib>Zuber, Isabelle</creatorcontrib><creatorcontrib>Studer, Sandro</creatorcontrib><creatorcontrib>Saake, Antje</creatorcontrib><creatorcontrib>Rauen, Katrin</creatorcontrib><creatorcontrib>Gruber, Esmeralda</creatorcontrib><creatorcontrib>Nitsch, Roger M.</creatorcontrib><creatorcontrib>Hock, Christoph</creatorcontrib><creatorcontrib>Gietl, Anton F.</creatorcontrib><creatorcontrib>Treyer, Valerie</creatorcontrib><title>Lifestyle Affects Amyloid Burden and Cognition Differently in Men and Women</title><title>Annals of neurology</title><addtitle>Ann Neurol</addtitle><description>Objective
Evidence on associations of lifestyle factors with Alzheimer's pathology and cognition are ambiguous, potentially because they rarely addressed inter‐relationships of factors and sex effects. While considering these aspects, we examined the relationships of lifestyle factors with brain amyloid burden and cognition.
Methods
We studied 178 cognitively normal individuals (women, 49%; 65.0 [7.6] years) and 54 individuals with mild cognitive impairment (women, 35%; 71.3 [8.3] years) enrolled in a prospective study of volunteers who completed 18F‐Flutemetamol amyloid positron emission tomography. Using structural equation modeling, we examined associations between latent constructs representing metabolic/vascular risk, physical activity, and cognitive activity with global amyloid burden and cognitive performance. Furthermore, we investigated the influence of sex in this model.
Results
Overall, higher cognitive activity was associated with better cognitive performance and higher physical activity was associated with lower amyloid burden. The latter association was weakened to a nonsignificant level after excluding multivariate outliers. Examination of the moderating effect of sex in the model revealed an inverse association of metabolic/vascular risk with cognition in men, whereas in women metabolic/vascular risk trended toward increased amyloid burden. Furthermore, a significant inverse association between physical activity and amyloid burden was found only in men. Inheritance of an APOE4 allele was associated with higher amyloid burden only in women.
Interpretation
Sex modifies effects of certain lifestyle‐related factors on amyloid burden and cognition. Notably, our results suggest that the negative impact of metabolic/vascular risk influences the risk of cognitive decline and Alzheimer's disease through distinct paths in women and men. ANN NEUROL 2022;92:451–463</description><subject>Alzheimer's disease</subject><subject>Cognition</subject><subject>Cognition & reasoning</subject><subject>Cognitive ability</subject><subject>Emission analysis</subject><subject>Heredity</subject><subject>Lifestyles</subject><subject>Men</subject><subject>Metabolism</subject><subject>Multivariate statistical analysis</subject><subject>Neurodegenerative diseases</subject><subject>Physical activity</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Risk</subject><subject>Sex</subject><subject>Women</subject><issn>0364-5134</issn><issn>1531-8249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><recordid>eNp10EtLw0AUhuFBFFurC_-ABNzoIu3cJ1nGesWqG8XlMElOZEoyqZkEyb83mupCcHU2Dx-HF6FjgucEY7owzsyp5ETtoCkRjIQR5fEummImeSgI4xN04P0aYxxLgvfRhAkRR1iRKbpf2QJ825cQJEUBWeuDpOrL2ubBRdfk4ALj8mBZvznb2toFl3ZQDbi27APrgocteK0rcIdorzClh6PtnaGX66vn5W24erq5WyarMOOcqpBnkWI5FVRkBchCKJmaDAglEjCGlJkcSEqlgZwSSIHHseBpxIykGS5iFrEZOht3N0393g3f68r6DMrSOKg7r6mUSkUKR2Sgp3_ouu4aN3ynqcKMRUIIPKjzUWVN7X0Dhd40tjJNrwnWX4X1UFh_Fx7syXaxSyvIf-VP0gEsRvBhS-j_X9LJYzJOfgLQGINI</recordid><startdate>202209</startdate><enddate>202209</enddate><creator>Bachmann, Dario</creator><creator>Roman, Zachary J.</creator><creator>Buchmann, Andreas</creator><creator>Zuber, Isabelle</creator><creator>Studer, Sandro</creator><creator>Saake, Antje</creator><creator>Rauen, Katrin</creator><creator>Gruber, Esmeralda</creator><creator>Nitsch, Roger M.</creator><creator>Hock, Christoph</creator><creator>Gietl, Anton F.</creator><creator>Treyer, Valerie</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4584-3031</orcidid><orcidid>https://orcid.org/0000-0001-8604-962X</orcidid><orcidid>https://orcid.org/0000-0002-2863-537X</orcidid><orcidid>https://orcid.org/0000-0003-4555-6697</orcidid></search><sort><creationdate>202209</creationdate><title>Lifestyle Affects Amyloid Burden and Cognition Differently in Men and Women</title><author>Bachmann, Dario ; Roman, Zachary J. ; Buchmann, Andreas ; Zuber, Isabelle ; Studer, Sandro ; Saake, Antje ; Rauen, Katrin ; Gruber, Esmeralda ; Nitsch, Roger M. ; Hock, Christoph ; Gietl, Anton F. ; Treyer, Valerie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4427-4c873d2525cfe6f576bace1216e00eb3ade1b26aed21ebe49954b83a62c0f9383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Alzheimer's disease</topic><topic>Cognition</topic><topic>Cognition & reasoning</topic><topic>Cognitive ability</topic><topic>Emission analysis</topic><topic>Heredity</topic><topic>Lifestyles</topic><topic>Men</topic><topic>Metabolism</topic><topic>Multivariate statistical analysis</topic><topic>Neurodegenerative diseases</topic><topic>Physical activity</topic><topic>Positron emission</topic><topic>Positron emission tomography</topic><topic>Risk</topic><topic>Sex</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bachmann, Dario</creatorcontrib><creatorcontrib>Roman, Zachary J.</creatorcontrib><creatorcontrib>Buchmann, Andreas</creatorcontrib><creatorcontrib>Zuber, Isabelle</creatorcontrib><creatorcontrib>Studer, Sandro</creatorcontrib><creatorcontrib>Saake, Antje</creatorcontrib><creatorcontrib>Rauen, Katrin</creatorcontrib><creatorcontrib>Gruber, Esmeralda</creatorcontrib><creatorcontrib>Nitsch, Roger M.</creatorcontrib><creatorcontrib>Hock, Christoph</creatorcontrib><creatorcontrib>Gietl, Anton F.</creatorcontrib><creatorcontrib>Treyer, Valerie</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bachmann, Dario</au><au>Roman, Zachary J.</au><au>Buchmann, Andreas</au><au>Zuber, Isabelle</au><au>Studer, Sandro</au><au>Saake, Antje</au><au>Rauen, Katrin</au><au>Gruber, Esmeralda</au><au>Nitsch, Roger M.</au><au>Hock, Christoph</au><au>Gietl, Anton F.</au><au>Treyer, Valerie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lifestyle Affects Amyloid Burden and Cognition Differently in Men and Women</atitle><jtitle>Annals of neurology</jtitle><addtitle>Ann Neurol</addtitle><date>2022-09</date><risdate>2022</risdate><volume>92</volume><issue>3</issue><spage>451</spage><epage>463</epage><pages>451-463</pages><issn>0364-5134</issn><eissn>1531-8249</eissn><abstract>Objective
Evidence on associations of lifestyle factors with Alzheimer's pathology and cognition are ambiguous, potentially because they rarely addressed inter‐relationships of factors and sex effects. While considering these aspects, we examined the relationships of lifestyle factors with brain amyloid burden and cognition.
Methods
We studied 178 cognitively normal individuals (women, 49%; 65.0 [7.6] years) and 54 individuals with mild cognitive impairment (women, 35%; 71.3 [8.3] years) enrolled in a prospective study of volunteers who completed 18F‐Flutemetamol amyloid positron emission tomography. Using structural equation modeling, we examined associations between latent constructs representing metabolic/vascular risk, physical activity, and cognitive activity with global amyloid burden and cognitive performance. Furthermore, we investigated the influence of sex in this model.
Results
Overall, higher cognitive activity was associated with better cognitive performance and higher physical activity was associated with lower amyloid burden. The latter association was weakened to a nonsignificant level after excluding multivariate outliers. Examination of the moderating effect of sex in the model revealed an inverse association of metabolic/vascular risk with cognition in men, whereas in women metabolic/vascular risk trended toward increased amyloid burden. Furthermore, a significant inverse association between physical activity and amyloid burden was found only in men. Inheritance of an APOE4 allele was associated with higher amyloid burden only in women.
Interpretation
Sex modifies effects of certain lifestyle‐related factors on amyloid burden and cognition. Notably, our results suggest that the negative impact of metabolic/vascular risk influences the risk of cognitive decline and Alzheimer's disease through distinct paths in women and men. ANN NEUROL 2022;92:451–463</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>35598071</pmid><doi>10.1002/ana.26417</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-4584-3031</orcidid><orcidid>https://orcid.org/0000-0001-8604-962X</orcidid><orcidid>https://orcid.org/0000-0002-2863-537X</orcidid><orcidid>https://orcid.org/0000-0003-4555-6697</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Annals of neurology, 2022-09, Vol.92 (3), p.451-463 |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Alzheimer's disease Cognition Cognition & reasoning Cognitive ability Emission analysis Heredity Lifestyles Men Metabolism Multivariate statistical analysis Neurodegenerative diseases Physical activity Positron emission Positron emission tomography Risk Sex Women |
| title | Lifestyle Affects Amyloid Burden and Cognition Differently in Men and Women |
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