Cabbage (Brassica oleracea) mitigates lead (II) acetate‐induced testicular dysfunction in Wistar rats via up‐regulation of Bcl‐2 protein expression, pituitary–testicular hormonal axis and down‐regulation of oxido‐inflammatory reactions
Oxido‐inflammatory stress has been involved in lead‐induced testicular dysfunction and plants rich in anti‐oxidants has been reported to be beneficial in combating heavy metal poisonings in animal studies. However, cabbage juice protective effect on lead‐induced testicular dysfunction was investigat...
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| Veröffentlicht in: | Andrologia 2022-09, Vol.54 (8), p.e14476-n/a |
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| creator | Kolawole, Tolunigba Abisola Asiwe, Jerome Ndudi Buduburisi, Buduchim Rejoice Akintade, Victoria Abimbola Adebayo, Olusegun Gafar Ojetola, Abodunrin Adebayo Dapper, Datonye Victor |
| description | Oxido‐inflammatory stress has been involved in lead‐induced testicular dysfunction and plants rich in anti‐oxidants has been reported to be beneficial in combating heavy metal poisonings in animal studies. However, cabbage juice protective effect on lead‐induced testicular dysfunction was investigated in this study. Twenty male Wistar rats were selected into four (n = 5) groups and given distilled water (1 ml/100 g body weight), lead acetate (25 mg/kg body weight), cabbage juice (1 ml/100 g body weight), and lead acetate with cabbage juice, respectively. All treatments were administered orally for 28 days. Sperm count, motility, viability, testosterone, luteinising hormone and follicle‐stimulating hormone, testicular Bcl‐2 expression, and enzymatic anti‐oxidant capabilities were considerably (p |
| doi_str_mv | 10.1111/and.14476 |
| format | Article |
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However, cabbage juice protective effect on lead‐induced testicular dysfunction was investigated in this study. Twenty male Wistar rats were selected into four (n = 5) groups and given distilled water (1 ml/100 g body weight), lead acetate (25 mg/kg body weight), cabbage juice (1 ml/100 g body weight), and lead acetate with cabbage juice, respectively. All treatments were administered orally for 28 days. Sperm count, motility, viability, testosterone, luteinising hormone and follicle‐stimulating hormone, testicular Bcl‐2 expression, and enzymatic anti‐oxidant capabilities were considerably (p < 0.05) decrease in lead‐treated animals. However, cabbage juice significantly (p < 0.05) elevated these parameters. Testicular malondialdehyde, tumour necrosis factor‐α, nitric oxide and interleukin‐6 was elevated by lead acetate. When comparing cabbage juice‐treated animals to lead‐treated animals, all of these parameters were considerably (p < 0.05) downregulated in cabbage juice‐treated animals. Following lead administration, the testes' histomorphological alterations were not totally recovered despite therapy with cabbage juice. Conclusively, this study suggest that cabbage juice mitigates testicular dysfunction associated with lead exposure via its anti‐oxidant, anti‐inflammatory, anti‐apoptotic and androgenic properties.</description><identifier>ISSN: 0303-4569</identifier><identifier>EISSN: 1439-0272</identifier><identifier>DOI: 10.1111/and.14476</identifier><identifier>PMID: 35598098</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Animals ; anti‐inflammation ; anti‐oxidants ; Apoptosis ; Body weight ; Brassica oleracea ; cabbage juice ; Heavy metals ; Inflammation ; Interleukin 6 ; Juices ; lead acetate ; Nitric oxide ; Oral administration ; Oxidants ; Pituitary ; Rodents ; Testes ; testicular dysfunction ; Testosterone ; Tumor necrosis factor ; Tumors</subject><ispartof>Andrologia, 2022-09, Vol.54 (8), p.e14476-n/a</ispartof><rights>2022 Wiley‐VCH GmbH.</rights><rights>2022 Wiley-VCH GmbH.</rights><rights>2022 Wiley‐VCH GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3536-538ff2c9e88354d276e587360f3c2efa00d80d5b9e5636dcb282f2d4156cd3033</citedby><cites>FETCH-LOGICAL-c3536-538ff2c9e88354d276e587360f3c2efa00d80d5b9e5636dcb282f2d4156cd3033</cites><orcidid>0000-0001-5600-8288</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fand.14476$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fand.14476$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35598098$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kolawole, Tolunigba Abisola</creatorcontrib><creatorcontrib>Asiwe, Jerome Ndudi</creatorcontrib><creatorcontrib>Buduburisi, Buduchim Rejoice</creatorcontrib><creatorcontrib>Akintade, Victoria Abimbola</creatorcontrib><creatorcontrib>Adebayo, Olusegun Gafar</creatorcontrib><creatorcontrib>Ojetola, Abodunrin Adebayo</creatorcontrib><creatorcontrib>Dapper, Datonye Victor</creatorcontrib><title>Cabbage (Brassica oleracea) mitigates lead (II) acetate‐induced testicular dysfunction in Wistar rats via up‐regulation of Bcl‐2 protein expression, pituitary–testicular hormonal axis and down‐regulation of oxido‐inflammatory reactions</title><title>Andrologia</title><addtitle>Andrologia</addtitle><description>Oxido‐inflammatory stress has been involved in lead‐induced testicular dysfunction and plants rich in anti‐oxidants has been reported to be beneficial in combating heavy metal poisonings in animal studies. However, cabbage juice protective effect on lead‐induced testicular dysfunction was investigated in this study. Twenty male Wistar rats were selected into four (n = 5) groups and given distilled water (1 ml/100 g body weight), lead acetate (25 mg/kg body weight), cabbage juice (1 ml/100 g body weight), and lead acetate with cabbage juice, respectively. All treatments were administered orally for 28 days. Sperm count, motility, viability, testosterone, luteinising hormone and follicle‐stimulating hormone, testicular Bcl‐2 expression, and enzymatic anti‐oxidant capabilities were considerably (p < 0.05) decrease in lead‐treated animals. However, cabbage juice significantly (p < 0.05) elevated these parameters. Testicular malondialdehyde, tumour necrosis factor‐α, nitric oxide and interleukin‐6 was elevated by lead acetate. When comparing cabbage juice‐treated animals to lead‐treated animals, all of these parameters were considerably (p < 0.05) downregulated in cabbage juice‐treated animals. Following lead administration, the testes' histomorphological alterations were not totally recovered despite therapy with cabbage juice. Conclusively, this study suggest that cabbage juice mitigates testicular dysfunction associated with lead exposure via its anti‐oxidant, anti‐inflammatory, anti‐apoptotic and androgenic properties.</description><subject>Animals</subject><subject>anti‐inflammation</subject><subject>anti‐oxidants</subject><subject>Apoptosis</subject><subject>Body weight</subject><subject>Brassica oleracea</subject><subject>cabbage juice</subject><subject>Heavy metals</subject><subject>Inflammation</subject><subject>Interleukin 6</subject><subject>Juices</subject><subject>lead acetate</subject><subject>Nitric oxide</subject><subject>Oral administration</subject><subject>Oxidants</subject><subject>Pituitary</subject><subject>Rodents</subject><subject>Testes</subject><subject>testicular dysfunction</subject><subject>Testosterone</subject><subject>Tumor necrosis factor</subject><subject>Tumors</subject><issn>0303-4569</issn><issn>1439-0272</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1ks1u1DAQxy0EoqvSAy-ALHHZlUjrxLHjHNvla6UKLiCOkWNPFldOvNgJ3b31EZB4w74EV6a7BSEQc7E085u_54uQpzk7zdHO9GBP87Ks5AMyy0teZ6yoiodkxjjjWSlkfUROUrpiaKWoqrJ8TI64ELVitZqRH0vdtnoNdH4RdUrOaBo8RG1AL2jvRrfWIyTqQVs6X60WFCMjum5vvrnBTgYsxfjozOR1pHaXumkwowsDdQP95NKI3qjHRL86TacNpkVYI7tHQkcvjEdfQTcxjIApsN1EwDrC8IJu3Dg5FNjd3nz_45PPIfZh0J7qrUsU26c2XA__KIets2FfZud13-sxxB2NoPfVpSfkUad9gpP795h8fP3qw_Jtdvn-zWp5fpkZLrjMBFddV5galOKitEUlQaiKS9ZxU0CnGbOKWdHWICSX1rSFKrrClrmQxuIC-DGZH3SxwS8TNtH0LhnwXg8QptQUUlaVkrUqEX3-F3oVpoiN3lG1rDmvc4bU4kCZGFKK0DWb6HocUpOz5u4gGpxIsz8IZJ_dK05tD_Y3-Wv9CJwdgGvnYfd_peb83cuD5E_p5crN</recordid><startdate>202209</startdate><enddate>202209</enddate><creator>Kolawole, Tolunigba Abisola</creator><creator>Asiwe, Jerome Ndudi</creator><creator>Buduburisi, Buduchim Rejoice</creator><creator>Akintade, Victoria Abimbola</creator><creator>Adebayo, Olusegun Gafar</creator><creator>Ojetola, Abodunrin Adebayo</creator><creator>Dapper, Datonye Victor</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5600-8288</orcidid></search><sort><creationdate>202209</creationdate><title>Cabbage (Brassica oleracea) mitigates lead (II) acetate‐induced testicular dysfunction in Wistar rats via up‐regulation of Bcl‐2 protein expression, pituitary–testicular hormonal axis and down‐regulation of oxido‐inflammatory reactions</title><author>Kolawole, Tolunigba Abisola ; Asiwe, Jerome Ndudi ; Buduburisi, Buduchim Rejoice ; Akintade, Victoria Abimbola ; Adebayo, Olusegun Gafar ; Ojetola, Abodunrin Adebayo ; Dapper, Datonye Victor</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3536-538ff2c9e88354d276e587360f3c2efa00d80d5b9e5636dcb282f2d4156cd3033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animals</topic><topic>anti‐inflammation</topic><topic>anti‐oxidants</topic><topic>Apoptosis</topic><topic>Body weight</topic><topic>Brassica oleracea</topic><topic>cabbage juice</topic><topic>Heavy metals</topic><topic>Inflammation</topic><topic>Interleukin 6</topic><topic>Juices</topic><topic>lead acetate</topic><topic>Nitric oxide</topic><topic>Oral administration</topic><topic>Oxidants</topic><topic>Pituitary</topic><topic>Rodents</topic><topic>Testes</topic><topic>testicular dysfunction</topic><topic>Testosterone</topic><topic>Tumor necrosis factor</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kolawole, Tolunigba Abisola</creatorcontrib><creatorcontrib>Asiwe, Jerome Ndudi</creatorcontrib><creatorcontrib>Buduburisi, Buduchim Rejoice</creatorcontrib><creatorcontrib>Akintade, Victoria Abimbola</creatorcontrib><creatorcontrib>Adebayo, Olusegun Gafar</creatorcontrib><creatorcontrib>Ojetola, Abodunrin Adebayo</creatorcontrib><creatorcontrib>Dapper, Datonye Victor</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Andrologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kolawole, Tolunigba Abisola</au><au>Asiwe, Jerome Ndudi</au><au>Buduburisi, Buduchim Rejoice</au><au>Akintade, Victoria Abimbola</au><au>Adebayo, Olusegun Gafar</au><au>Ojetola, Abodunrin Adebayo</au><au>Dapper, Datonye Victor</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cabbage (Brassica oleracea) mitigates lead (II) acetate‐induced testicular dysfunction in Wistar rats via up‐regulation of Bcl‐2 protein expression, pituitary–testicular hormonal axis and down‐regulation of oxido‐inflammatory reactions</atitle><jtitle>Andrologia</jtitle><addtitle>Andrologia</addtitle><date>2022-09</date><risdate>2022</risdate><volume>54</volume><issue>8</issue><spage>e14476</spage><epage>n/a</epage><pages>e14476-n/a</pages><issn>0303-4569</issn><eissn>1439-0272</eissn><abstract>Oxido‐inflammatory stress has been involved in lead‐induced testicular dysfunction and plants rich in anti‐oxidants has been reported to be beneficial in combating heavy metal poisonings in animal studies. However, cabbage juice protective effect on lead‐induced testicular dysfunction was investigated in this study. Twenty male Wistar rats were selected into four (n = 5) groups and given distilled water (1 ml/100 g body weight), lead acetate (25 mg/kg body weight), cabbage juice (1 ml/100 g body weight), and lead acetate with cabbage juice, respectively. All treatments were administered orally for 28 days. Sperm count, motility, viability, testosterone, luteinising hormone and follicle‐stimulating hormone, testicular Bcl‐2 expression, and enzymatic anti‐oxidant capabilities were considerably (p < 0.05) decrease in lead‐treated animals. However, cabbage juice significantly (p < 0.05) elevated these parameters. Testicular malondialdehyde, tumour necrosis factor‐α, nitric oxide and interleukin‐6 was elevated by lead acetate. When comparing cabbage juice‐treated animals to lead‐treated animals, all of these parameters were considerably (p < 0.05) downregulated in cabbage juice‐treated animals. Following lead administration, the testes' histomorphological alterations were not totally recovered despite therapy with cabbage juice. Conclusively, this study suggest that cabbage juice mitigates testicular dysfunction associated with lead exposure via its anti‐oxidant, anti‐inflammatory, anti‐apoptotic and androgenic properties.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>35598098</pmid><doi>10.1111/and.14476</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-5600-8288</orcidid></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Animals anti‐inflammation anti‐oxidants Apoptosis Body weight Brassica oleracea cabbage juice Heavy metals Inflammation Interleukin 6 Juices lead acetate Nitric oxide Oral administration Oxidants Pituitary Rodents Testes testicular dysfunction Testosterone Tumor necrosis factor Tumors |
| title | Cabbage (Brassica oleracea) mitigates lead (II) acetate‐induced testicular dysfunction in Wistar rats via up‐regulation of Bcl‐2 protein expression, pituitary–testicular hormonal axis and down‐regulation of oxido‐inflammatory reactions |
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