LC‐MS/MS methods for determination of unstable pivmecillinam and mecillinam in acidified human plasma: Application to a pharmacokinetic study

Pivmecillinam, the ester of biologically active antibiotic mecillinam, is an effective oral preparation to treat urinary tract infections. To study pharmacokinetics in humans, LC‐MS/MS methods were developed to quantify pivmecillinam and mecillinam in human plasma, respectively. Considering cephalex...

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Veröffentlicht in:	Journal of separation science 2022-07, Vol.45 (14), p.2543-2554
Hauptverfasser:	Sun, Lu‐Ning, Zhao, Yang, Gao, Hua‐Ye, Yang, Yan‐Ling, Qian, Xu‐Ping, Sun, Shi‐Yu, Wang, Yu, Ding, Li, Wang, Yong‐Qing
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetonitrile Acidification Antibiotics Blood plasma Cephalexin Formic acid human plasma mecillinam Pharmacokinetics Pharmacology pivmecillinam Positive ions Stability tests tandem mass spectrometry
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