Diastereoselective Synthesis, Glycosidase Inhibition, and Docking Study of C‑7-Fluorinated Casuarine and Australine Derivatives

C-7-fluorinated derivatives of two important polyhydroxylated pyrrolizidines, casuarine and australine, were synthesized with organocatalytic stereoselective α-fluorination of aldehydes as the key step. The strategy is extensively applicable to some synthetically challenging fluorinated iminosugars...

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Veröffentlicht in:	Journal of organic chemistry 2022-06, Vol.87 (11), p.7291-7307
Hauptverfasser:	Li, Yi-Xian, Wang, Jun-Zhe, Shimadate, Yuna, Kise, Maki, Kato, Atsushi, Jia, Yue-Mei, Fleet, George W. J., Yu, Chu-Yi
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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