Molecular Dynamics Simulations Indicate Aromaticity as a Key Factor in the Inhibition of IAPP(20–29) Aggregation

Islet amyloid polypeptide (IAPP) is a 37-residue amyloidogenic hormone implicated in the progression of Type II Diabetes (T2D). T2D affects an estimated 422 million people yearly and is a comorbidity with numerous diseases. IAPP forms toxic oligomers and amyloid fibrils that reduce pancreatic β-cell...

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Veröffentlicht in:	ACS chemical neuroscience 2022-06, Vol.13 (11), p.1615-1626
Hauptverfasser:	King, Kelsie M., Bevan, David R., Brown, Anne M.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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