Thyroid nodules of indeterminate cytology in Hispanic/Latinx patients
Background Behavior of differentiated thyroid cancer (DTC) varies among ethnic groups. Recommended management of thyroid nodules with indeterminate cytology (TN‐IC) is based on molecular analysis from predominantly non‐Hispanic white patients. We hypothesized that TN‐IC in Hispanic/Latinx patients w...
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| Veröffentlicht in: | Head & neck 2022-08, Vol.44 (8), p.1842-1848 |
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| creator | Kerr, Catherine E. Ferrell, Jay Kitano, Mio Koek, Wouter Dahia, Patricia L. M. Velez, Jorge Francis, Gary |
| description | Background
Behavior of differentiated thyroid cancer (DTC) varies among ethnic groups. Recommended management of thyroid nodules with indeterminate cytology (TN‐IC) is based on molecular analysis from predominantly non‐Hispanic white patients. We hypothesized that TN‐IC in Hispanic/Latinx patients would have different features, management, and outcomes and that molecular testing might perform differently in Hispanic/Latinx patients.
Methods
Retrospective chart review was performed on 127 TN‐IC analyzed with Afirma. Patient characteristics were compared using linear model ANOVA and Fisher's exact test.
Results
Out of 127 TN‐IC, 71 (56%) were Hispanic/Latinx. Hispanic/Latinx had a greater prevalence of diabetes, but Afirma results (benign or suspicious) were similar between ethnic groups. Fourteen patients had malignant pathology. Their management and outcomes were similar across groups. The negative predictive value for our cohort (97.9%) was similar to published data.
Conclusions
Data from our predominantly‐Hispanic/Latinx cohort suggest that Afirma performs similarly in Hispanic/Latinx and non‐Hispanic white patients with TN‐IC. |
| doi_str_mv | 10.1002/hed.27100 |
| format | Article |
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Behavior of differentiated thyroid cancer (DTC) varies among ethnic groups. Recommended management of thyroid nodules with indeterminate cytology (TN‐IC) is based on molecular analysis from predominantly non‐Hispanic white patients. We hypothesized that TN‐IC in Hispanic/Latinx patients would have different features, management, and outcomes and that molecular testing might perform differently in Hispanic/Latinx patients.
Methods
Retrospective chart review was performed on 127 TN‐IC analyzed with Afirma. Patient characteristics were compared using linear model ANOVA and Fisher's exact test.
Results
Out of 127 TN‐IC, 71 (56%) were Hispanic/Latinx. Hispanic/Latinx had a greater prevalence of diabetes, but Afirma results (benign or suspicious) were similar between ethnic groups. Fourteen patients had malignant pathology. Their management and outcomes were similar across groups. The negative predictive value for our cohort (97.9%) was similar to published data.
Conclusions
Data from our predominantly‐Hispanic/Latinx cohort suggest that Afirma performs similarly in Hispanic/Latinx and non‐Hispanic white patients with TN‐IC.</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.27100</identifier><identifier>PMID: 35583054</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>cancer ; Cytology ; Diabetes mellitus ; Hispanic/Latinx ; minority ; Minority & ethnic groups ; nodule ; Nodules ; thyroid ; Thyroid cancer</subject><ispartof>Head & neck, 2022-08, Vol.44 (8), p.1842-1848</ispartof><rights>2022 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3880-313ee79172fc13a50d11a97e06f682b26edf5ee15afc8e92d79382ffff9665323</citedby><cites>FETCH-LOGICAL-c3880-313ee79172fc13a50d11a97e06f682b26edf5ee15afc8e92d79382ffff9665323</cites><orcidid>0000-0002-3823-2507 ; 0000-0003-3782-5658</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.27100$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.27100$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35583054$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kerr, Catherine E.</creatorcontrib><creatorcontrib>Ferrell, Jay</creatorcontrib><creatorcontrib>Kitano, Mio</creatorcontrib><creatorcontrib>Koek, Wouter</creatorcontrib><creatorcontrib>Dahia, Patricia L. M.</creatorcontrib><creatorcontrib>Velez, Jorge</creatorcontrib><creatorcontrib>Francis, Gary</creatorcontrib><title>Thyroid nodules of indeterminate cytology in Hispanic/Latinx patients</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
Behavior of differentiated thyroid cancer (DTC) varies among ethnic groups. Recommended management of thyroid nodules with indeterminate cytology (TN‐IC) is based on molecular analysis from predominantly non‐Hispanic white patients. We hypothesized that TN‐IC in Hispanic/Latinx patients would have different features, management, and outcomes and that molecular testing might perform differently in Hispanic/Latinx patients.
Methods
Retrospective chart review was performed on 127 TN‐IC analyzed with Afirma. Patient characteristics were compared using linear model ANOVA and Fisher's exact test.
Results
Out of 127 TN‐IC, 71 (56%) were Hispanic/Latinx. Hispanic/Latinx had a greater prevalence of diabetes, but Afirma results (benign or suspicious) were similar between ethnic groups. Fourteen patients had malignant pathology. Their management and outcomes were similar across groups. The negative predictive value for our cohort (97.9%) was similar to published data.
Conclusions
Data from our predominantly‐Hispanic/Latinx cohort suggest that Afirma performs similarly in Hispanic/Latinx and non‐Hispanic white patients with TN‐IC.</description><subject>cancer</subject><subject>Cytology</subject><subject>Diabetes mellitus</subject><subject>Hispanic/Latinx</subject><subject>minority</subject><subject>Minority & ethnic groups</subject><subject>nodule</subject><subject>Nodules</subject><subject>thyroid</subject><subject>Thyroid cancer</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp10E9LwzAYBvAgitPpwS8gBS966JY_TdMeZU4nDLzMc8naty6jTWrSov32pna7CObyvrz8eAgPQjcEzwjGdL6DYkaFX0_QBcGpCDGLxOmwRyxkWEQTdOncHmPM4oieownjPGGYRxdoudn11qgi0KboKnCBKQOlC2jB1krLFoK8b01lPnp_DlbKNVKrfL6WrdLfQeMH6NZdobNSVg6uD3OK3p-Xm8UqXL-9vC4e12HOkgSHjDAAkRJBy5wwyXFBiEwF4LiME7qlMRQlByBclnkCKS1EyhJa-pfGMWeUTdH9mNtY89mBa7NauRyqSmowncto7B3HSTzQuz90bzqr_e-8SliKfTmDehhVbo1zFsqssaqWts8IzoZuM99t9tutt7eHxG5b--tRHsv0YD6CL1VB_39Stlo-jZE_USaBtg</recordid><startdate>202208</startdate><enddate>202208</enddate><creator>Kerr, Catherine E.</creator><creator>Ferrell, Jay</creator><creator>Kitano, Mio</creator><creator>Koek, Wouter</creator><creator>Dahia, Patricia L. M.</creator><creator>Velez, Jorge</creator><creator>Francis, Gary</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3823-2507</orcidid><orcidid>https://orcid.org/0000-0003-3782-5658</orcidid></search><sort><creationdate>202208</creationdate><title>Thyroid nodules of indeterminate cytology in Hispanic/Latinx patients</title><author>Kerr, Catherine E. ; Ferrell, Jay ; Kitano, Mio ; Koek, Wouter ; Dahia, Patricia L. M. ; Velez, Jorge ; Francis, Gary</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3880-313ee79172fc13a50d11a97e06f682b26edf5ee15afc8e92d79382ffff9665323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>cancer</topic><topic>Cytology</topic><topic>Diabetes mellitus</topic><topic>Hispanic/Latinx</topic><topic>minority</topic><topic>Minority & ethnic groups</topic><topic>nodule</topic><topic>Nodules</topic><topic>thyroid</topic><topic>Thyroid cancer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kerr, Catherine E.</creatorcontrib><creatorcontrib>Ferrell, Jay</creatorcontrib><creatorcontrib>Kitano, Mio</creatorcontrib><creatorcontrib>Koek, Wouter</creatorcontrib><creatorcontrib>Dahia, Patricia L. M.</creatorcontrib><creatorcontrib>Velez, Jorge</creatorcontrib><creatorcontrib>Francis, Gary</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kerr, Catherine E.</au><au>Ferrell, Jay</au><au>Kitano, Mio</au><au>Koek, Wouter</au><au>Dahia, Patricia L. M.</au><au>Velez, Jorge</au><au>Francis, Gary</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thyroid nodules of indeterminate cytology in Hispanic/Latinx patients</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2022-08</date><risdate>2022</risdate><volume>44</volume><issue>8</issue><spage>1842</spage><epage>1848</epage><pages>1842-1848</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background
Behavior of differentiated thyroid cancer (DTC) varies among ethnic groups. Recommended management of thyroid nodules with indeterminate cytology (TN‐IC) is based on molecular analysis from predominantly non‐Hispanic white patients. We hypothesized that TN‐IC in Hispanic/Latinx patients would have different features, management, and outcomes and that molecular testing might perform differently in Hispanic/Latinx patients.
Methods
Retrospective chart review was performed on 127 TN‐IC analyzed with Afirma. Patient characteristics were compared using linear model ANOVA and Fisher's exact test.
Results
Out of 127 TN‐IC, 71 (56%) were Hispanic/Latinx. Hispanic/Latinx had a greater prevalence of diabetes, but Afirma results (benign or suspicious) were similar between ethnic groups. Fourteen patients had malignant pathology. Their management and outcomes were similar across groups. The negative predictive value for our cohort (97.9%) was similar to published data.
Conclusions
Data from our predominantly‐Hispanic/Latinx cohort suggest that Afirma performs similarly in Hispanic/Latinx and non‐Hispanic white patients with TN‐IC.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>35583054</pmid><doi>10.1002/hed.27100</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-3823-2507</orcidid><orcidid>https://orcid.org/0000-0003-3782-5658</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Head & neck, 2022-08, Vol.44 (8), p.1842-1848 |
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| language | eng |
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| source | Wiley Online Library Journals |
| subjects | cancer Cytology Diabetes mellitus Hispanic/Latinx minority Minority & ethnic groups nodule Nodules thyroid Thyroid cancer |
| title | Thyroid nodules of indeterminate cytology in Hispanic/Latinx patients |
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