Relationship between different hepatitis B virus infection status and gestational diabetes mellitus prevalence among pregnant women with chronic HBV infection: A retrospective study

To investigate the relationships between different hepatitis B virus (HBV) infection status and gestational diabetes mellitus (GDM) and analyse the potential risk factors, we conducted an observational retrospective study in HBV‐infected pregnant women to compare the differences of GDM prevalence an...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of viral hepatitis 2022-08, Vol.29 (8), p.596-603
Hauptverfasser: Zhou, Guanlun, Chen, Chao, Han, Guorong, Jiang, Hongxiu, Cao, Minkai
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 603
container_issue 8
container_start_page 596
container_title Journal of viral hepatitis
container_volume 29
creator Zhou, Guanlun
Chen, Chao
Han, Guorong
Jiang, Hongxiu
Cao, Minkai
description To investigate the relationships between different hepatitis B virus (HBV) infection status and gestational diabetes mellitus (GDM) and analyse the potential risk factors, we conducted an observational retrospective study in HBV‐infected pregnant women to compare the differences of GDM prevalence and clinical outcomes between groups divided by HBV infection status. Spearman's correlation coefficient was used to evaluate the correlations among hepatitis B e antigen (HBeAg), HBV DNA and liver function. Logistic regression model was used to analyse the risk factors. In all, 1390 HBsAg‐positive pregnant women were enrolled. HBeAg titre and HBV DNA, ALT and AST were correlated (r = 0.743, p 
doi_str_mv 10.1111/jvh.13700
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2666550604</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2687588260</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3530-7c819780b743230a089adf348a991266071f855145f46e934afc27dcdb66e2243</originalsourceid><addsrcrecordid>eNp1kc1u1DAUhS0EoqWw4AWQJTZlkdY_seOwayvKgCohIeg28jjXE48SJ9jJjObBeD_sTgEJCW9sH3_3XF0fhF5TckHTutzuugvKK0KeoFPKpSiYqvnTfBasIIKUJ-hFjFtCKGeCPkcnXAjFlGSn6OdX6PXsRh87N-E1zHsAj1tnLQTwM-5gSs-zi_ga71xYInbegskVOM56ToL2Ld5AviRR96lYJx-IeIC-d5mYAux0D94A1sPoN1nYeJ3s9-OQ2u3d3GHThdE7g1fX9397vMdXOMAcxjhlYQep6dIeXqJnVvcRXj3uZ-j77YdvN6vi7svHTzdXd4XhgpOiMorWlSLrquSME01UrVvLS6XrmjIpSUWtEoKWwpYSal5qa1jVmnYtJTBW8jN0fvSdwvhjSTM2g4smjaU9jEtskocUgkiS0bf_oNtxCek_MqUqoRSTJFHvjpRJI8UAtpmCG3Q4NJQ0OcsmZdk8ZJnYN4-Oy3qA9g_5O7wEXB6Bvevh8H-n5vP96mj5CyODq6k</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2687588260</pqid></control><display><type>article</type><title>Relationship between different hepatitis B virus infection status and gestational diabetes mellitus prevalence among pregnant women with chronic HBV infection: A retrospective study</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Zhou, Guanlun ; Chen, Chao ; Han, Guorong ; Jiang, Hongxiu ; Cao, Minkai</creator><creatorcontrib>Zhou, Guanlun ; Chen, Chao ; Han, Guorong ; Jiang, Hongxiu ; Cao, Minkai</creatorcontrib><description>To investigate the relationships between different hepatitis B virus (HBV) infection status and gestational diabetes mellitus (GDM) and analyse the potential risk factors, we conducted an observational retrospective study in HBV‐infected pregnant women to compare the differences of GDM prevalence and clinical outcomes between groups divided by HBV infection status. Spearman's correlation coefficient was used to evaluate the correlations among hepatitis B e antigen (HBeAg), HBV DNA and liver function. Logistic regression model was used to analyse the risk factors. In all, 1390 HBsAg‐positive pregnant women were enrolled. HBeAg titre and HBV DNA, ALT and AST were correlated (r = 0.743, p &lt; 0.001; r = 0.813, p &lt; 0.001). Overall GDM prevalence was 21%. GDM prevalence of HBV‐infected women with abnormal liver function was higher than those with normal liver function (26.8% vs. 20%, p = 0.027). Age over 35 years and abnormal liver function over 5 times ULN and 1–2 times ULN were independent risk factors for GDM prevalence with odds ratio (OR) of 1.858 (95% CI 1.227–2.815), 1.589 (95% CI 1.023–2.468) and 2.203 (95% CI 1.029–4.718), respectively. GDM prevalence in HBV‐infected pregnancies with abnormal liver function was higher than those with normal liver function. Age over 35 years and abnormal liver function were independent risk factors for GDM in HBV‐infected women.</description><identifier>ISSN: 1352-0504</identifier><identifier>EISSN: 1365-2893</identifier><identifier>DOI: 10.1111/jvh.13700</identifier><identifier>PMID: 35582862</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Chronic infection ; Deoxyribonucleic acid ; Diabetes mellitus ; DNA ; Gestational diabetes ; gestational diabetes mellitus ; Hepatitis B ; Hepatitis B e antigen ; hepatitis B e antigens ; Hepatitis B surface antigen ; hepatitis B virus ; Infections ; Liver ; liver function ; Pregnancy ; Risk factors ; viral load</subject><ispartof>Journal of viral hepatitis, 2022-08, Vol.29 (8), p.596-603</ispartof><rights>2022 John Wiley &amp; Sons Ltd.</rights><rights>This article is protected by copyright. All rights reserved.</rights><rights>Copyright © 2022 John Wiley &amp; Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3530-7c819780b743230a089adf348a991266071f855145f46e934afc27dcdb66e2243</citedby><cites>FETCH-LOGICAL-c3530-7c819780b743230a089adf348a991266071f855145f46e934afc27dcdb66e2243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjvh.13700$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjvh.13700$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35582862$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Guanlun</creatorcontrib><creatorcontrib>Chen, Chao</creatorcontrib><creatorcontrib>Han, Guorong</creatorcontrib><creatorcontrib>Jiang, Hongxiu</creatorcontrib><creatorcontrib>Cao, Minkai</creatorcontrib><title>Relationship between different hepatitis B virus infection status and gestational diabetes mellitus prevalence among pregnant women with chronic HBV infection: A retrospective study</title><title>Journal of viral hepatitis</title><addtitle>J Viral Hepat</addtitle><description>To investigate the relationships between different hepatitis B virus (HBV) infection status and gestational diabetes mellitus (GDM) and analyse the potential risk factors, we conducted an observational retrospective study in HBV‐infected pregnant women to compare the differences of GDM prevalence and clinical outcomes between groups divided by HBV infection status. Spearman's correlation coefficient was used to evaluate the correlations among hepatitis B e antigen (HBeAg), HBV DNA and liver function. Logistic regression model was used to analyse the risk factors. In all, 1390 HBsAg‐positive pregnant women were enrolled. HBeAg titre and HBV DNA, ALT and AST were correlated (r = 0.743, p &lt; 0.001; r = 0.813, p &lt; 0.001). Overall GDM prevalence was 21%. GDM prevalence of HBV‐infected women with abnormal liver function was higher than those with normal liver function (26.8% vs. 20%, p = 0.027). Age over 35 years and abnormal liver function over 5 times ULN and 1–2 times ULN were independent risk factors for GDM prevalence with odds ratio (OR) of 1.858 (95% CI 1.227–2.815), 1.589 (95% CI 1.023–2.468) and 2.203 (95% CI 1.029–4.718), respectively. GDM prevalence in HBV‐infected pregnancies with abnormal liver function was higher than those with normal liver function. Age over 35 years and abnormal liver function were independent risk factors for GDM in HBV‐infected women.</description><subject>Chronic infection</subject><subject>Deoxyribonucleic acid</subject><subject>Diabetes mellitus</subject><subject>DNA</subject><subject>Gestational diabetes</subject><subject>gestational diabetes mellitus</subject><subject>Hepatitis B</subject><subject>Hepatitis B e antigen</subject><subject>hepatitis B e antigens</subject><subject>Hepatitis B surface antigen</subject><subject>hepatitis B virus</subject><subject>Infections</subject><subject>Liver</subject><subject>liver function</subject><subject>Pregnancy</subject><subject>Risk factors</subject><subject>viral load</subject><issn>1352-0504</issn><issn>1365-2893</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1kc1u1DAUhS0EoqWw4AWQJTZlkdY_seOwayvKgCohIeg28jjXE48SJ9jJjObBeD_sTgEJCW9sH3_3XF0fhF5TckHTutzuugvKK0KeoFPKpSiYqvnTfBasIIKUJ-hFjFtCKGeCPkcnXAjFlGSn6OdX6PXsRh87N-E1zHsAj1tnLQTwM-5gSs-zi_ga71xYInbegskVOM56ToL2Ld5AviRR96lYJx-IeIC-d5mYAux0D94A1sPoN1nYeJ3s9-OQ2u3d3GHThdE7g1fX9397vMdXOMAcxjhlYQep6dIeXqJnVvcRXj3uZ-j77YdvN6vi7svHTzdXd4XhgpOiMorWlSLrquSME01UrVvLS6XrmjIpSUWtEoKWwpYSal5qa1jVmnYtJTBW8jN0fvSdwvhjSTM2g4smjaU9jEtskocUgkiS0bf_oNtxCek_MqUqoRSTJFHvjpRJI8UAtpmCG3Q4NJQ0OcsmZdk8ZJnYN4-Oy3qA9g_5O7wEXB6Bvevh8H-n5vP96mj5CyODq6k</recordid><startdate>202208</startdate><enddate>202208</enddate><creator>Zhou, Guanlun</creator><creator>Chen, Chao</creator><creator>Han, Guorong</creator><creator>Jiang, Hongxiu</creator><creator>Cao, Minkai</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>202208</creationdate><title>Relationship between different hepatitis B virus infection status and gestational diabetes mellitus prevalence among pregnant women with chronic HBV infection: A retrospective study</title><author>Zhou, Guanlun ; Chen, Chao ; Han, Guorong ; Jiang, Hongxiu ; Cao, Minkai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3530-7c819780b743230a089adf348a991266071f855145f46e934afc27dcdb66e2243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Chronic infection</topic><topic>Deoxyribonucleic acid</topic><topic>Diabetes mellitus</topic><topic>DNA</topic><topic>Gestational diabetes</topic><topic>gestational diabetes mellitus</topic><topic>Hepatitis B</topic><topic>Hepatitis B e antigen</topic><topic>hepatitis B e antigens</topic><topic>Hepatitis B surface antigen</topic><topic>hepatitis B virus</topic><topic>Infections</topic><topic>Liver</topic><topic>liver function</topic><topic>Pregnancy</topic><topic>Risk factors</topic><topic>viral load</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Guanlun</creatorcontrib><creatorcontrib>Chen, Chao</creatorcontrib><creatorcontrib>Han, Guorong</creatorcontrib><creatorcontrib>Jiang, Hongxiu</creatorcontrib><creatorcontrib>Cao, Minkai</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of viral hepatitis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Guanlun</au><au>Chen, Chao</au><au>Han, Guorong</au><au>Jiang, Hongxiu</au><au>Cao, Minkai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between different hepatitis B virus infection status and gestational diabetes mellitus prevalence among pregnant women with chronic HBV infection: A retrospective study</atitle><jtitle>Journal of viral hepatitis</jtitle><addtitle>J Viral Hepat</addtitle><date>2022-08</date><risdate>2022</risdate><volume>29</volume><issue>8</issue><spage>596</spage><epage>603</epage><pages>596-603</pages><issn>1352-0504</issn><eissn>1365-2893</eissn><abstract>To investigate the relationships between different hepatitis B virus (HBV) infection status and gestational diabetes mellitus (GDM) and analyse the potential risk factors, we conducted an observational retrospective study in HBV‐infected pregnant women to compare the differences of GDM prevalence and clinical outcomes between groups divided by HBV infection status. Spearman's correlation coefficient was used to evaluate the correlations among hepatitis B e antigen (HBeAg), HBV DNA and liver function. Logistic regression model was used to analyse the risk factors. In all, 1390 HBsAg‐positive pregnant women were enrolled. HBeAg titre and HBV DNA, ALT and AST were correlated (r = 0.743, p &lt; 0.001; r = 0.813, p &lt; 0.001). Overall GDM prevalence was 21%. GDM prevalence of HBV‐infected women with abnormal liver function was higher than those with normal liver function (26.8% vs. 20%, p = 0.027). Age over 35 years and abnormal liver function over 5 times ULN and 1–2 times ULN were independent risk factors for GDM prevalence with odds ratio (OR) of 1.858 (95% CI 1.227–2.815), 1.589 (95% CI 1.023–2.468) and 2.203 (95% CI 1.029–4.718), respectively. GDM prevalence in HBV‐infected pregnancies with abnormal liver function was higher than those with normal liver function. Age over 35 years and abnormal liver function were independent risk factors for GDM in HBV‐infected women.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>35582862</pmid><doi>10.1111/jvh.13700</doi><tpages>8</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1352-0504
ispartof Journal of viral hepatitis, 2022-08, Vol.29 (8), p.596-603
issn 1352-0504
1365-2893
language eng
recordid cdi_proquest_miscellaneous_2666550604
source Wiley Online Library Journals Frontfile Complete
subjects Chronic infection
Deoxyribonucleic acid
Diabetes mellitus
DNA
Gestational diabetes
gestational diabetes mellitus
Hepatitis B
Hepatitis B e antigen
hepatitis B e antigens
Hepatitis B surface antigen
hepatitis B virus
Infections
Liver
liver function
Pregnancy
Risk factors
viral load
title Relationship between different hepatitis B virus infection status and gestational diabetes mellitus prevalence among pregnant women with chronic HBV infection: A retrospective study
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T18%3A01%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Relationship%20between%20different%20hepatitis%20B%20virus%20infection%20status%20and%20gestational%20diabetes%20mellitus%20prevalence%20among%20pregnant%20women%20with%20chronic%20HBV%20infection:%20A%20retrospective%20study&rft.jtitle=Journal%20of%20viral%20hepatitis&rft.au=Zhou,%20Guanlun&rft.date=2022-08&rft.volume=29&rft.issue=8&rft.spage=596&rft.epage=603&rft.pages=596-603&rft.issn=1352-0504&rft.eissn=1365-2893&rft_id=info:doi/10.1111/jvh.13700&rft_dat=%3Cproquest_cross%3E2687588260%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2687588260&rft_id=info:pmid/35582862&rfr_iscdi=true