Systemic administration of lipopolysaccharide induces hyperexcitability of prelimbic neurons via modulation of sodium and potassium currents

In C57BL/6 J mice, systemic inflammation was induced by administering bacterial LPS (1 mg/kg) intraperitoneally. In response, animals exhibited hypokinesia, piloerection, and a slight decrease in body temperature accompanied by increased serum levels of the proinflammatory cytokine TNF-α. 24 h after...

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Veröffentlicht in:	Neurotoxicology (Park Forest South) 2022-07, Vol.91, p.128-139
Hauptverfasser:	Griego, Ernesto, Santiago-Jiménez, Guadalupe, Galván, Emilio J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Intrinsic excitability LPS Potassium channels Prelimbic cortex Sodium channels
Online-Zugang:	Volltext
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