Myocardial microvascular function assessed by CMR first-pass perfusion in patients treated with chemotherapy for gynecologic malignancies
Objectives Cancer chemotherapy potentially increases the risk of myocardial ischemia. This study assessed myocardial microvascular function by cardiac magnetic resonance (CMR) first-pass perfusion in patients treated with chemotherapy for gynecologic malignancies. Methods A total of 81 patients trea...
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| Veröffentlicht in: | European radiology 2022-10, Vol.32 (10), p.6850-6858 |
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| creator | Yang, Meng-Xi Li, Qing-Li Wang, Dan-Qing Ye, Lu Li, Ke-Min Lin, Xiao-Juan Li, Xue-Sheng Fu, Chuan Ma, Xin-Mao Guo, Ying-Kun Yin, Ru-Tie Yang, Zhi-Gang |
| description | Objectives
Cancer chemotherapy potentially increases the risk of myocardial ischemia. This study assessed myocardial microvascular function by cardiac magnetic resonance (CMR) first-pass perfusion in patients treated with chemotherapy for gynecologic malignancies.
Methods
A total of 81 patients treated with chemotherapy for gynecologic malignancies and 39 healthy volunteers were prospectively enrolled and underwent CMR imaging. Among the patients, 32 completed CMR follow-up, with a median interval of 6 months. The CMR sequences comprised cardiac cine, rest first-pass perfusion, and late gadolinium enhancement.
Results
There were no significant differences in the baseline characteristics between the patients and normal controls (all
p
> 0.05). Compared with the normal controls, the patients had a lower myocardial perfusion index (PI) (13.62 ± 2.01% vs. 12% (11 to 14%),
p
= 0.001) but demonstrated no significant variation with an increase in the number of chemotherapy cycles at follow-up (11.79 ± 2.36% vs. 11.19 ± 2.19%,
p
= 0.234). In multivariate analysis with adjustments for clinical confounders, a decrease in the PI was independently associated with chemotherapy treatment (
β
= − 0.362,
p
= 0.002) but had no correlation with the number of chemotherapy cycles (
r
= − 0.177,
p
= 0.053).
Conclusion
Myocardial microvascular dysfunction was associated with chemotherapy treatment in patients with gynecologic malignancies, and can be assessed and monitored by rest CMR first-pass perfusion.
Key Points
•
Chemotherapy was associated with but did not aggravate myocardial microvascular dysfunction in patients with gynecologic malignancies.
•
Rest CMR first-pass perfusion is an ideal modality for assessing and monitoring alterations in myocardial microcirculation during chemotherapy treatment. |
| doi_str_mv | 10.1007/s00330-022-08823-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2665562167</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2665562167</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-3d47ec1bcdca51246281d229e1219ba1fd6742f0099a33f03597a36f014cb6413</originalsourceid><addsrcrecordid>eNp9kcFqHSEUhqW0NGmSF-iiCN1kM6lHnXFmWS5NG0golGYtjqP3GmZ0qk7KPELeOqY3SUMXBUHR7_xH_RB6D-QMCBGfEiGMkYpQWpG2payir9AhcEYrIC1__WJ9gN6ldEMI6YCLt-iA1bXoBNBDdHe1Bq3i4NSIJ6djuFVJL6OK2C5eZxc8VimZMgbcr3hz9QNbF1Ou5rKNZxPtkh4g5_GssjM-J5yjUbnwv13eYb0zU8g7E9W8Yhsi3q7e6DCGrdN4UqPbeuW1M-kYvbFqTObkcT5C1-dffm6-VZffv15sPl9Wmok6V2zgwmjo9aBVDZQ3tIWB0s4Aha5XYIdGcGrLUzvFmCWs7oRijSXAdd9wYEfodJ87x_BrMSnLySVtxlF5E5YkadPUdUOhEQX9-A96E5boy-0kFcChbZnoCkX3VPm9lKKxco5uUnGVQOSDKLkXJYso-UeUpKXow2P00k9meC55MlMAtgdSOfJbE__2_k_sPapRoBs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2714188379</pqid></control><display><type>article</type><title>Myocardial microvascular function assessed by CMR first-pass perfusion in patients treated with chemotherapy for gynecologic malignancies</title><source>Springer LINK 全文期刊数据库</source><creator>Yang, Meng-Xi ; Li, Qing-Li ; Wang, Dan-Qing ; Ye, Lu ; Li, Ke-Min ; Lin, Xiao-Juan ; Li, Xue-Sheng ; Fu, Chuan ; Ma, Xin-Mao ; Guo, Ying-Kun ; Yin, Ru-Tie ; Yang, Zhi-Gang</creator><creatorcontrib>Yang, Meng-Xi ; Li, Qing-Li ; Wang, Dan-Qing ; Ye, Lu ; Li, Ke-Min ; Lin, Xiao-Juan ; Li, Xue-Sheng ; Fu, Chuan ; Ma, Xin-Mao ; Guo, Ying-Kun ; Yin, Ru-Tie ; Yang, Zhi-Gang</creatorcontrib><description>Objectives
Cancer chemotherapy potentially increases the risk of myocardial ischemia. This study assessed myocardial microvascular function by cardiac magnetic resonance (CMR) first-pass perfusion in patients treated with chemotherapy for gynecologic malignancies.
Methods
A total of 81 patients treated with chemotherapy for gynecologic malignancies and 39 healthy volunteers were prospectively enrolled and underwent CMR imaging. Among the patients, 32 completed CMR follow-up, with a median interval of 6 months. The CMR sequences comprised cardiac cine, rest first-pass perfusion, and late gadolinium enhancement.
Results
There were no significant differences in the baseline characteristics between the patients and normal controls (all
p
> 0.05). Compared with the normal controls, the patients had a lower myocardial perfusion index (PI) (13.62 ± 2.01% vs. 12% (11 to 14%),
p
= 0.001) but demonstrated no significant variation with an increase in the number of chemotherapy cycles at follow-up (11.79 ± 2.36% vs. 11.19 ± 2.19%,
p
= 0.234). In multivariate analysis with adjustments for clinical confounders, a decrease in the PI was independently associated with chemotherapy treatment (
β
= − 0.362,
p
= 0.002) but had no correlation with the number of chemotherapy cycles (
r
= − 0.177,
p
= 0.053).
Conclusion
Myocardial microvascular dysfunction was associated with chemotherapy treatment in patients with gynecologic malignancies, and can be assessed and monitored by rest CMR first-pass perfusion.
Key Points
•
Chemotherapy was associated with but did not aggravate myocardial microvascular dysfunction in patients with gynecologic malignancies.
•
Rest CMR first-pass perfusion is an ideal modality for assessing and monitoring alterations in myocardial microcirculation during chemotherapy treatment.</description><identifier>ISSN: 1432-1084</identifier><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-022-08823-2</identifier><identifier>PMID: 35579712</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Cardiac ; Chemotherapy ; Diagnostic Radiology ; Gadolinium ; Heart ; Imaging ; Internal Medicine ; Interventional Radiology ; Ischemia ; Magnetic resonance ; Medicine ; Medicine & Public Health ; Microvasculature ; Multivariate analysis ; Myocardial ischemia ; Neuroradiology ; Patients ; Perfusion ; Radiology ; Ultrasound</subject><ispartof>European radiology, 2022-10, Vol.32 (10), p.6850-6858</ispartof><rights>The Author(s), under exclusive licence to European Society of Radiology 2022</rights><rights>2022. The Author(s), under exclusive licence to European Society of Radiology.</rights><rights>The Author(s), under exclusive licence to European Society of Radiology 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-3d47ec1bcdca51246281d229e1219ba1fd6742f0099a33f03597a36f014cb6413</citedby><cites>FETCH-LOGICAL-c375t-3d47ec1bcdca51246281d229e1219ba1fd6742f0099a33f03597a36f014cb6413</cites><orcidid>0000-0001-9341-7697</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-022-08823-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-022-08823-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35579712$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Meng-Xi</creatorcontrib><creatorcontrib>Li, Qing-Li</creatorcontrib><creatorcontrib>Wang, Dan-Qing</creatorcontrib><creatorcontrib>Ye, Lu</creatorcontrib><creatorcontrib>Li, Ke-Min</creatorcontrib><creatorcontrib>Lin, Xiao-Juan</creatorcontrib><creatorcontrib>Li, Xue-Sheng</creatorcontrib><creatorcontrib>Fu, Chuan</creatorcontrib><creatorcontrib>Ma, Xin-Mao</creatorcontrib><creatorcontrib>Guo, Ying-Kun</creatorcontrib><creatorcontrib>Yin, Ru-Tie</creatorcontrib><creatorcontrib>Yang, Zhi-Gang</creatorcontrib><title>Myocardial microvascular function assessed by CMR first-pass perfusion in patients treated with chemotherapy for gynecologic malignancies</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Objectives
Cancer chemotherapy potentially increases the risk of myocardial ischemia. This study assessed myocardial microvascular function by cardiac magnetic resonance (CMR) first-pass perfusion in patients treated with chemotherapy for gynecologic malignancies.
Methods
A total of 81 patients treated with chemotherapy for gynecologic malignancies and 39 healthy volunteers were prospectively enrolled and underwent CMR imaging. Among the patients, 32 completed CMR follow-up, with a median interval of 6 months. The CMR sequences comprised cardiac cine, rest first-pass perfusion, and late gadolinium enhancement.
Results
There were no significant differences in the baseline characteristics between the patients and normal controls (all
p
> 0.05). Compared with the normal controls, the patients had a lower myocardial perfusion index (PI) (13.62 ± 2.01% vs. 12% (11 to 14%),
p
= 0.001) but demonstrated no significant variation with an increase in the number of chemotherapy cycles at follow-up (11.79 ± 2.36% vs. 11.19 ± 2.19%,
p
= 0.234). In multivariate analysis with adjustments for clinical confounders, a decrease in the PI was independently associated with chemotherapy treatment (
β
= − 0.362,
p
= 0.002) but had no correlation with the number of chemotherapy cycles (
r
= − 0.177,
p
= 0.053).
Conclusion
Myocardial microvascular dysfunction was associated with chemotherapy treatment in patients with gynecologic malignancies, and can be assessed and monitored by rest CMR first-pass perfusion.
Key Points
•
Chemotherapy was associated with but did not aggravate myocardial microvascular dysfunction in patients with gynecologic malignancies.
•
Rest CMR first-pass perfusion is an ideal modality for assessing and monitoring alterations in myocardial microcirculation during chemotherapy treatment.</description><subject>Cardiac</subject><subject>Chemotherapy</subject><subject>Diagnostic Radiology</subject><subject>Gadolinium</subject><subject>Heart</subject><subject>Imaging</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Ischemia</subject><subject>Magnetic resonance</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microvasculature</subject><subject>Multivariate analysis</subject><subject>Myocardial ischemia</subject><subject>Neuroradiology</subject><subject>Patients</subject><subject>Perfusion</subject><subject>Radiology</subject><subject>Ultrasound</subject><issn>1432-1084</issn><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kcFqHSEUhqW0NGmSF-iiCN1kM6lHnXFmWS5NG0golGYtjqP3GmZ0qk7KPELeOqY3SUMXBUHR7_xH_RB6D-QMCBGfEiGMkYpQWpG2payir9AhcEYrIC1__WJ9gN6ldEMI6YCLt-iA1bXoBNBDdHe1Bq3i4NSIJ6djuFVJL6OK2C5eZxc8VimZMgbcr3hz9QNbF1Ou5rKNZxPtkh4g5_GssjM-J5yjUbnwv13eYb0zU8g7E9W8Yhsi3q7e6DCGrdN4UqPbeuW1M-kYvbFqTObkcT5C1-dffm6-VZffv15sPl9Wmok6V2zgwmjo9aBVDZQ3tIWB0s4Aha5XYIdGcGrLUzvFmCWs7oRijSXAdd9wYEfodJ87x_BrMSnLySVtxlF5E5YkadPUdUOhEQX9-A96E5boy-0kFcChbZnoCkX3VPm9lKKxco5uUnGVQOSDKLkXJYso-UeUpKXow2P00k9meC55MlMAtgdSOfJbE__2_k_sPapRoBs</recordid><startdate>20221001</startdate><enddate>20221001</enddate><creator>Yang, Meng-Xi</creator><creator>Li, Qing-Li</creator><creator>Wang, Dan-Qing</creator><creator>Ye, Lu</creator><creator>Li, Ke-Min</creator><creator>Lin, Xiao-Juan</creator><creator>Li, Xue-Sheng</creator><creator>Fu, Chuan</creator><creator>Ma, Xin-Mao</creator><creator>Guo, Ying-Kun</creator><creator>Yin, Ru-Tie</creator><creator>Yang, Zhi-Gang</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9341-7697</orcidid></search><sort><creationdate>20221001</creationdate><title>Myocardial microvascular function assessed by CMR first-pass perfusion in patients treated with chemotherapy for gynecologic malignancies</title><author>Yang, Meng-Xi ; Li, Qing-Li ; Wang, Dan-Qing ; Ye, Lu ; Li, Ke-Min ; Lin, Xiao-Juan ; Li, Xue-Sheng ; Fu, Chuan ; Ma, Xin-Mao ; Guo, Ying-Kun ; Yin, Ru-Tie ; Yang, Zhi-Gang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-3d47ec1bcdca51246281d229e1219ba1fd6742f0099a33f03597a36f014cb6413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Cardiac</topic><topic>Chemotherapy</topic><topic>Diagnostic Radiology</topic><topic>Gadolinium</topic><topic>Heart</topic><topic>Imaging</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Ischemia</topic><topic>Magnetic resonance</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microvasculature</topic><topic>Multivariate analysis</topic><topic>Myocardial ischemia</topic><topic>Neuroradiology</topic><topic>Patients</topic><topic>Perfusion</topic><topic>Radiology</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Meng-Xi</creatorcontrib><creatorcontrib>Li, Qing-Li</creatorcontrib><creatorcontrib>Wang, Dan-Qing</creatorcontrib><creatorcontrib>Ye, Lu</creatorcontrib><creatorcontrib>Li, Ke-Min</creatorcontrib><creatorcontrib>Lin, Xiao-Juan</creatorcontrib><creatorcontrib>Li, Xue-Sheng</creatorcontrib><creatorcontrib>Fu, Chuan</creatorcontrib><creatorcontrib>Ma, Xin-Mao</creatorcontrib><creatorcontrib>Guo, Ying-Kun</creatorcontrib><creatorcontrib>Yin, Ru-Tie</creatorcontrib><creatorcontrib>Yang, Zhi-Gang</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database 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journals</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Meng-Xi</au><au>Li, Qing-Li</au><au>Wang, Dan-Qing</au><au>Ye, Lu</au><au>Li, Ke-Min</au><au>Lin, Xiao-Juan</au><au>Li, Xue-Sheng</au><au>Fu, Chuan</au><au>Ma, Xin-Mao</au><au>Guo, Ying-Kun</au><au>Yin, Ru-Tie</au><au>Yang, Zhi-Gang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myocardial microvascular function assessed by CMR first-pass perfusion in patients treated with chemotherapy for gynecologic malignancies</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2022-10-01</date><risdate>2022</risdate><volume>32</volume><issue>10</issue><spage>6850</spage><epage>6858</epage><pages>6850-6858</pages><issn>1432-1084</issn><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Objectives
Cancer chemotherapy potentially increases the risk of myocardial ischemia. This study assessed myocardial microvascular function by cardiac magnetic resonance (CMR) first-pass perfusion in patients treated with chemotherapy for gynecologic malignancies.
Methods
A total of 81 patients treated with chemotherapy for gynecologic malignancies and 39 healthy volunteers were prospectively enrolled and underwent CMR imaging. Among the patients, 32 completed CMR follow-up, with a median interval of 6 months. The CMR sequences comprised cardiac cine, rest first-pass perfusion, and late gadolinium enhancement.
Results
There were no significant differences in the baseline characteristics between the patients and normal controls (all
p
> 0.05). Compared with the normal controls, the patients had a lower myocardial perfusion index (PI) (13.62 ± 2.01% vs. 12% (11 to 14%),
p
= 0.001) but demonstrated no significant variation with an increase in the number of chemotherapy cycles at follow-up (11.79 ± 2.36% vs. 11.19 ± 2.19%,
p
= 0.234). In multivariate analysis with adjustments for clinical confounders, a decrease in the PI was independently associated with chemotherapy treatment (
β
= − 0.362,
p
= 0.002) but had no correlation with the number of chemotherapy cycles (
r
= − 0.177,
p
= 0.053).
Conclusion
Myocardial microvascular dysfunction was associated with chemotherapy treatment in patients with gynecologic malignancies, and can be assessed and monitored by rest CMR first-pass perfusion.
Key Points
•
Chemotherapy was associated with but did not aggravate myocardial microvascular dysfunction in patients with gynecologic malignancies.
•
Rest CMR first-pass perfusion is an ideal modality for assessing and monitoring alterations in myocardial microcirculation during chemotherapy treatment.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35579712</pmid><doi>10.1007/s00330-022-08823-2</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-9341-7697</orcidid></addata></record> |
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| ispartof | European radiology, 2022-10, Vol.32 (10), p.6850-6858 |
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| source | Springer LINK 全文期刊数据库 |
| subjects | Cardiac Chemotherapy Diagnostic Radiology Gadolinium Heart Imaging Internal Medicine Interventional Radiology Ischemia Magnetic resonance Medicine Medicine & Public Health Microvasculature Multivariate analysis Myocardial ischemia Neuroradiology Patients Perfusion Radiology Ultrasound |
| title | Myocardial microvascular function assessed by CMR first-pass perfusion in patients treated with chemotherapy for gynecologic malignancies |
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