The Precision and Accuracy of 3D Printing of Tablets by Fused Deposition Modelling
Tablet manufacture by fused deposition modelling (FDM) can be carried out individually (one tablet printed per run) or as a group (i.e., ‘multiple printing’ in one run) depending on patient's needs. The assessment of the process of printing must take into consideration the precision and the acc...
Gespeichert in:
| Veröffentlicht in: | Journal of pharmaceutical sciences 2022-10, Vol.111 (10), p.2814-2826 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2826 |
|---|---|
| container_issue | 10 |
| container_start_page | 2814 |
| container_title | Journal of pharmaceutical sciences |
| container_volume | 111 |
| creator | Macedo, Joana da Costa, Nuno F. Vanhoorne, Valérie Vervaet, Chris Pinto, João F. |
| description | Tablet manufacture by fused deposition modelling (FDM) can be carried out individually (one tablet printed per run) or as a group (i.e., ‘multiple printing’ in one run) depending on patient's needs. The assessment of the process of printing must take into consideration the precision and the accuracy of the mass and dose of tablets, together with their solid-state properties and drug dissolution behaviour. Different mixtures made of either poly(vinyl alcohol) and paracetamol or hydroxypropylcellulose EF and hydrochlorothiazide were used to evaluate multiple printing of tablets by manufacturing batches of 30 tablets with nozzles of 0.4 and 0.7 mm, in two different printers. Besides testing for mass, drug content, density and dissolution performance, tablets were analysed for their thermal (DSC) and spectroscopic (NIR and FTIR) properties. Low standard deviations around mean values for the different properties measured suggested low intra-batch variability. Statistical analysis of data revealed no significant differences between the batches for most of the properties considered in the study. Inter-batch differences (p |
| doi_str_mv | 10.1016/j.xphs.2022.05.006 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2665561351</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022354922001988</els_id><sourcerecordid>2665561351</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-348bce372226343c82eb47ab756bc1f54e9635286bc70f0507c9837f091ad9803</originalsourceid><addsrcrecordid>eNp9kEFLwzAUx4Mobk6_gAfp0UvrS9IkLXgZzqkwUWSeQ5u-uoytrU0r7tubsunRU3i83_9P3o-QSwoRBSpv1tF3s3IRA8YiEBGAPCJjKhiEEqg6JmPwm5CLOB2RM-fW4AkQ4pSMuBBKURqPydtyhcFri8Y6W1dBVhXB1Ji-zcwuqMuAz_zSVp2tPoZxmeUb7FyQ74J577AIZtjUznZD9LkucLPx4Dk5KbONw4vDOyHv8_vl3WO4eHl4upsuQsOF7EIeJ7lBrhhjksfcJAzzWGW5EjI3tBQxppILlvhJQQkClEkTrkpIaVakCfAJud73Nm392aPr9NY64_-QVVj3TjMphZCUC-pRtkdNWzvXYqmb1m6zdqcp6MGlXuvBpR5cahDam_Khq0N_n2-x-Iv8yvPA7R5Af-WXxVY7Y7EyWFgvtNNFbf_r_wFHmoNw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2665561351</pqid></control><display><type>article</type><title>The Precision and Accuracy of 3D Printing of Tablets by Fused Deposition Modelling</title><source>Alma/SFX Local Collection</source><creator>Macedo, Joana ; da Costa, Nuno F. ; Vanhoorne, Valérie ; Vervaet, Chris ; Pinto, João F.</creator><creatorcontrib>Macedo, Joana ; da Costa, Nuno F. ; Vanhoorne, Valérie ; Vervaet, Chris ; Pinto, João F.</creatorcontrib><description>Tablet manufacture by fused deposition modelling (FDM) can be carried out individually (one tablet printed per run) or as a group (i.e., ‘multiple printing’ in one run) depending on patient's needs. The assessment of the process of printing must take into consideration the precision and the accuracy of the mass and dose of tablets, together with their solid-state properties and drug dissolution behaviour. Different mixtures made of either poly(vinyl alcohol) and paracetamol or hydroxypropylcellulose EF and hydrochlorothiazide were used to evaluate multiple printing of tablets by manufacturing batches of 30 tablets with nozzles of 0.4 and 0.7 mm, in two different printers. Besides testing for mass, drug content, density and dissolution performance, tablets were analysed for their thermal (DSC) and spectroscopic (NIR and FTIR) properties. Low standard deviations around mean values for the different properties measured suggested low intra-batch variability. Statistical analysis of data revealed no significant differences between the batches for most of the properties considered in the study. Inter-batch differences (p<0.05) were observed only for mass of tablets, possibly due to deviation on filament's diameter. The use of a smaller nozzle or a different printer enabled the manufacture of more reproducible tablets within a batch. Multiple printing revealed a significant saving on manufacturing time (>35%) in comparison to individual printing.
[Display omitted]
•FDM enables the manufacture of multitablet batches with high precision and accuracy.•Intra-batch mass and drug content variabilities were within pharmacopoeal limits.•Tablet's mass variability best reflected variations on filament's diameter.•Nozzle narrower diameter led to higher printing resolution and lower inter-batch variability.•Printing of multiple tablets in a single run reduces the individual time of printing.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1016/j.xphs.2022.05.006</identifier><identifier>PMID: 35577114</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Additive manufacturing ; Fused deposition modelling ; Hydroxypropylcellulose ; Poly(vinyl alcohol) ; Printing accuracy ; Printing precision</subject><ispartof>Journal of pharmaceutical sciences, 2022-10, Vol.111 (10), p.2814-2826</ispartof><rights>2022</rights><rights>Copyright © 2022. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-348bce372226343c82eb47ab756bc1f54e9635286bc70f0507c9837f091ad9803</citedby><cites>FETCH-LOGICAL-c356t-348bce372226343c82eb47ab756bc1f54e9635286bc70f0507c9837f091ad9803</cites><orcidid>0000-0001-9728-705X ; 0000-0002-3211-8316 ; 0000-0003-4249-3408</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35577114$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Macedo, Joana</creatorcontrib><creatorcontrib>da Costa, Nuno F.</creatorcontrib><creatorcontrib>Vanhoorne, Valérie</creatorcontrib><creatorcontrib>Vervaet, Chris</creatorcontrib><creatorcontrib>Pinto, João F.</creatorcontrib><title>The Precision and Accuracy of 3D Printing of Tablets by Fused Deposition Modelling</title><title>Journal of pharmaceutical sciences</title><addtitle>J Pharm Sci</addtitle><description>Tablet manufacture by fused deposition modelling (FDM) can be carried out individually (one tablet printed per run) or as a group (i.e., ‘multiple printing’ in one run) depending on patient's needs. The assessment of the process of printing must take into consideration the precision and the accuracy of the mass and dose of tablets, together with their solid-state properties and drug dissolution behaviour. Different mixtures made of either poly(vinyl alcohol) and paracetamol or hydroxypropylcellulose EF and hydrochlorothiazide were used to evaluate multiple printing of tablets by manufacturing batches of 30 tablets with nozzles of 0.4 and 0.7 mm, in two different printers. Besides testing for mass, drug content, density and dissolution performance, tablets were analysed for their thermal (DSC) and spectroscopic (NIR and FTIR) properties. Low standard deviations around mean values for the different properties measured suggested low intra-batch variability. Statistical analysis of data revealed no significant differences between the batches for most of the properties considered in the study. Inter-batch differences (p<0.05) were observed only for mass of tablets, possibly due to deviation on filament's diameter. The use of a smaller nozzle or a different printer enabled the manufacture of more reproducible tablets within a batch. Multiple printing revealed a significant saving on manufacturing time (>35%) in comparison to individual printing.
[Display omitted]
•FDM enables the manufacture of multitablet batches with high precision and accuracy.•Intra-batch mass and drug content variabilities were within pharmacopoeal limits.•Tablet's mass variability best reflected variations on filament's diameter.•Nozzle narrower diameter led to higher printing resolution and lower inter-batch variability.•Printing of multiple tablets in a single run reduces the individual time of printing.</description><subject>Additive manufacturing</subject><subject>Fused deposition modelling</subject><subject>Hydroxypropylcellulose</subject><subject>Poly(vinyl alcohol)</subject><subject>Printing accuracy</subject><subject>Printing precision</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kEFLwzAUx4Mobk6_gAfp0UvrS9IkLXgZzqkwUWSeQ5u-uoytrU0r7tubsunRU3i83_9P3o-QSwoRBSpv1tF3s3IRA8YiEBGAPCJjKhiEEqg6JmPwm5CLOB2RM-fW4AkQ4pSMuBBKURqPydtyhcFri8Y6W1dBVhXB1Ji-zcwuqMuAz_zSVp2tPoZxmeUb7FyQ74J577AIZtjUznZD9LkucLPx4Dk5KbONw4vDOyHv8_vl3WO4eHl4upsuQsOF7EIeJ7lBrhhjksfcJAzzWGW5EjI3tBQxppILlvhJQQkClEkTrkpIaVakCfAJud73Nm392aPr9NY64_-QVVj3TjMphZCUC-pRtkdNWzvXYqmb1m6zdqcp6MGlXuvBpR5cahDam_Khq0N_n2-x-Iv8yvPA7R5Af-WXxVY7Y7EyWFgvtNNFbf_r_wFHmoNw</recordid><startdate>20221001</startdate><enddate>20221001</enddate><creator>Macedo, Joana</creator><creator>da Costa, Nuno F.</creator><creator>Vanhoorne, Valérie</creator><creator>Vervaet, Chris</creator><creator>Pinto, João F.</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9728-705X</orcidid><orcidid>https://orcid.org/0000-0002-3211-8316</orcidid><orcidid>https://orcid.org/0000-0003-4249-3408</orcidid></search><sort><creationdate>20221001</creationdate><title>The Precision and Accuracy of 3D Printing of Tablets by Fused Deposition Modelling</title><author>Macedo, Joana ; da Costa, Nuno F. ; Vanhoorne, Valérie ; Vervaet, Chris ; Pinto, João F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-348bce372226343c82eb47ab756bc1f54e9635286bc70f0507c9837f091ad9803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Additive manufacturing</topic><topic>Fused deposition modelling</topic><topic>Hydroxypropylcellulose</topic><topic>Poly(vinyl alcohol)</topic><topic>Printing accuracy</topic><topic>Printing precision</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Macedo, Joana</creatorcontrib><creatorcontrib>da Costa, Nuno F.</creatorcontrib><creatorcontrib>Vanhoorne, Valérie</creatorcontrib><creatorcontrib>Vervaet, Chris</creatorcontrib><creatorcontrib>Pinto, João F.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Macedo, Joana</au><au>da Costa, Nuno F.</au><au>Vanhoorne, Valérie</au><au>Vervaet, Chris</au><au>Pinto, João F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Precision and Accuracy of 3D Printing of Tablets by Fused Deposition Modelling</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J Pharm Sci</addtitle><date>2022-10-01</date><risdate>2022</risdate><volume>111</volume><issue>10</issue><spage>2814</spage><epage>2826</epage><pages>2814-2826</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>Tablet manufacture by fused deposition modelling (FDM) can be carried out individually (one tablet printed per run) or as a group (i.e., ‘multiple printing’ in one run) depending on patient's needs. The assessment of the process of printing must take into consideration the precision and the accuracy of the mass and dose of tablets, together with their solid-state properties and drug dissolution behaviour. Different mixtures made of either poly(vinyl alcohol) and paracetamol or hydroxypropylcellulose EF and hydrochlorothiazide were used to evaluate multiple printing of tablets by manufacturing batches of 30 tablets with nozzles of 0.4 and 0.7 mm, in two different printers. Besides testing for mass, drug content, density and dissolution performance, tablets were analysed for their thermal (DSC) and spectroscopic (NIR and FTIR) properties. Low standard deviations around mean values for the different properties measured suggested low intra-batch variability. Statistical analysis of data revealed no significant differences between the batches for most of the properties considered in the study. Inter-batch differences (p<0.05) were observed only for mass of tablets, possibly due to deviation on filament's diameter. The use of a smaller nozzle or a different printer enabled the manufacture of more reproducible tablets within a batch. Multiple printing revealed a significant saving on manufacturing time (>35%) in comparison to individual printing.
[Display omitted]
•FDM enables the manufacture of multitablet batches with high precision and accuracy.•Intra-batch mass and drug content variabilities were within pharmacopoeal limits.•Tablet's mass variability best reflected variations on filament's diameter.•Nozzle narrower diameter led to higher printing resolution and lower inter-batch variability.•Printing of multiple tablets in a single run reduces the individual time of printing.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>35577114</pmid><doi>10.1016/j.xphs.2022.05.006</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-9728-705X</orcidid><orcidid>https://orcid.org/0000-0002-3211-8316</orcidid><orcidid>https://orcid.org/0000-0003-4249-3408</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 2022-10, Vol.111 (10), p.2814-2826 |
| issn | 0022-3549 1520-6017 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2665561351 |
| source | Alma/SFX Local Collection |
| subjects | Additive manufacturing Fused deposition modelling Hydroxypropylcellulose Poly(vinyl alcohol) Printing accuracy Printing precision |
| title | The Precision and Accuracy of 3D Printing of Tablets by Fused Deposition Modelling |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-14T10%3A15%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Precision%20and%20Accuracy%20of%203D%20Printing%20of%20Tablets%20by%20Fused%20Deposition%20Modelling&rft.jtitle=Journal%20of%20pharmaceutical%20sciences&rft.au=Macedo,%20Joana&rft.date=2022-10-01&rft.volume=111&rft.issue=10&rft.spage=2814&rft.epage=2826&rft.pages=2814-2826&rft.issn=0022-3549&rft.eissn=1520-6017&rft_id=info:doi/10.1016/j.xphs.2022.05.006&rft_dat=%3Cproquest_cross%3E2665561351%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2665561351&rft_id=info:pmid/35577114&rft_els_id=S0022354922001988&rfr_iscdi=true |