BmK DKK13, A Scorpion Toxin, Alleviates Pain Behavior in a Rat Model of Trigeminal Neuralgia by Modulating Voltage-Gated Sodium Channels and MAPKs/CREB Pathway

BmK DKK13 (DKK13) is a mutated recombinant peptide, which has a significant antinociception in a rat model of the inflammatory pain. The purpose of this study was to evaluate the antinociceptive effect of DKK13 on trigeminal neuralgia (TN) in rats. Male Sprague–Dawley (SD) rats were treated with the...

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Veröffentlicht in:	Molecular neurobiology 2022-07, Vol.59 (7), p.4535-4549
Hauptverfasser:	Yang, Ran, Song, Yongbo, Wang, Haipeng, Chen, Chunyun, Bai, Fei, Li, Chunli
Format:	Artikel
Sprache:	eng
Schlagworte:	Behavior Biomedical and Life Sciences Biomedicine Cell Biology Cyclic AMP response element-binding protein Depolarization Electrophysiology Hyperpolarization Inflammation Morphine Neuralgia Neurobiology Neurology Neurosciences Pain Pain perception Phosphorylation Scratching behavior Sodium channels (voltage-gated) Trigeminal ganglion Trigeminal nerve Western blotting
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