Top-Down Rational Engineering of Heteroatom-Doped Graphene Quantum Dots for Laser Desorption/Ionization Mass Spectrometry Detection and Imaging of Small Biomolecules

Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) is widely applied in mapping macrobiomolecules in tissues, but it is still limited in profiling low-molecular-weight (MW) compounds (typically metabolites) due to ion interference and suppression by organic matrices. H...

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Veröffentlicht in:	Analytical chemistry (Washington) 2022-05, Vol.94 (21), p.7609-7618
Hauptverfasser:	Jin, Zehui, Liu, Meng, Huang, Xiaodan, Zhang, Xuemeng, Qu, Zexing, Zhu, Jun-Jie, Min, Qianhao
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animal tissues Antineoplastic drugs Antitumor agents Bases (nucleic acids) Biomedical materials Biomolecules Boron Brain Carbohydrates Chemistry Density functional theory Desorption Energy transfer Enzyme kinetics Fatty acids Geographical distribution Graphene Head injuries Imaging Ionization Ions Lipids Mass spectrometry Mass spectroscopy Metabolites Nanomaterials Negative ions Neuroimaging Nitrogen Peptides Pollutants Quantum dots Reproducibility Saccharides Salinity tolerance Salt tolerance Scientific imaging Spectroscopy Substrates Traumatic brain injury
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