New pyrazole-tetrazole hybrid compounds as potent α-amylase and non-enzymatic glycation inhibitors

[Display omitted] The synthesis of eight novel pyrazole-tetrazole compounds are presented. Their structures are identified by NMR and FTIR spectroscopy, mass spectrometry as well as elemental analysis. Their in-vitro α-amylase inhibition and haemoglobin antiglycation activity were examined by spectr...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2022-08, Vol.69, p.128785-128785, Article 128785
Hauptverfasser:	Oulous, Ahlam, Daoudi, Nour Elhouda, Harit, Tarik, Cherfi, Mounir, Bnouham, Mohamed, Malek, Fouad
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Amylases Antiglycation DFT calculation Diabetes Mellitus, Type 2 Docking Humans Pyrazole Pyrazoles - chemistry Pyridines - pharmacology Tetrazole Tetrazoles - pharmacology α-Amylase
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