Attribution of diabetes to the development of severe liver disease in the general population
Background and Aims Diabetes is associated with advanced liver disease and predicts mortality regardless of the primary aetiology of the liver disease. Even a family history of diabetes has been linked to advanced liver fibrosis in non‐alcoholic fatty liver disease (NAFLD). However, the fraction of...
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| Veröffentlicht in: | Liver international 2022-10, Vol.42 (10), p.2186-2194 |
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| container_volume | 42 |
| creator | Vuorinen, Miika Männistö, Ville T. Salomaa, Veikko Britton, Annie Jula, Antti Männistö, Satu Lundqvist, Annamari Perola, Markus Åberg, Fredrik |
| description | Background and Aims
Diabetes is associated with advanced liver disease and predicts mortality regardless of the primary aetiology of the liver disease. Even a family history of diabetes has been linked to advanced liver fibrosis in non‐alcoholic fatty liver disease (NAFLD). However, the fraction of liver‐related outcomes in the general population that are attributable to diabetes remains unclear.
Methods
The population attributable fraction (PAF) of diabetes for liver disease as a time‐dependent exposure was estimated in the Finnish FINRISK study (n = 28 787) and the British Whitehall II study (n = 7855). We also assessed the predictive ability of a family history of diabetes for liver‐related outcomes. Incident diabetes data were from drug purchase/reimbursement and healthcare registries (FINRISK) or follow‐up examinations (Whitehall II). Incident severe liver outcomes were identified through linkage with national healthcare registries.
Results
Diabetes was associated with a two‐fold risk of liver‐related outcomes in both the FINRISK (HR, 1.92; p |
| doi_str_mv | 10.1111/liv.15296 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2665105307</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2707729258</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3886-e47cd4b37c3d2f0a1b65149c73bbfe47c3479630943f31c175c35163ac092843</originalsourceid><addsrcrecordid>eNp1kM9LwzAYhoMoTqcH_wEpeNHDtvxomuY4hj8GAy_DkxDS9Kt2dE1N2sn-e9Nt7iCYSxLeh-f7eBG6IXhMwplU5WZMOJXJCbogsUhHjDJyenxTNkCX3q8wJlJyco4GjHMRS5leoPdp27oy69rS1pEtorzUGbTgo9ZG7SdEOWygss0a6raPffg6iMJAcIH1oD1EZb1DP6AGp6uosU1X6V54hc4KXXm4PtxDtHx6XM5eRovX5_lsuhgZlqbJCGJh8jhjwrCcFliTLOEklkawLCv6kMVCJgzLmBWMGCK4YZwkTBssaRqzIbrfaxtnvzrwrVqX3kBV6Rps5xVNgg9zhkVA7_6gK9u5OiynqMBCUEl5GqiHPWWc9d5BoRpXrrXbKoJV37gKBahd44G9PRi7bA35kfytOACTPfBdVrD936QW87e98gelpYnC</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2707729258</pqid></control><display><type>article</type><title>Attribution of diabetes to the development of severe liver disease in the general population</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Vuorinen, Miika ; Männistö, Ville T. ; Salomaa, Veikko ; Britton, Annie ; Jula, Antti ; Männistö, Satu ; Lundqvist, Annamari ; Perola, Markus ; Åberg, Fredrik</creator><creatorcontrib>Vuorinen, Miika ; Männistö, Ville T. ; Salomaa, Veikko ; Britton, Annie ; Jula, Antti ; Männistö, Satu ; Lundqvist, Annamari ; Perola, Markus ; Åberg, Fredrik</creatorcontrib><description>Background and Aims
Diabetes is associated with advanced liver disease and predicts mortality regardless of the primary aetiology of the liver disease. Even a family history of diabetes has been linked to advanced liver fibrosis in non‐alcoholic fatty liver disease (NAFLD). However, the fraction of liver‐related outcomes in the general population that are attributable to diabetes remains unclear.
Methods
The population attributable fraction (PAF) of diabetes for liver disease as a time‐dependent exposure was estimated in the Finnish FINRISK study (n = 28 787) and the British Whitehall II study (n = 7855). We also assessed the predictive ability of a family history of diabetes for liver‐related outcomes. Incident diabetes data were from drug purchase/reimbursement and healthcare registries (FINRISK) or follow‐up examinations (Whitehall II). Incident severe liver outcomes were identified through linkage with national healthcare registries.
Results
Diabetes was associated with a two‐fold risk of liver‐related outcomes in both the FINRISK (HR, 1.92; p < .001) and Whitehall II (HR, 2.37; p < .001) cohorts, and this remained significant after adjusting for multiple confounders. PAF analyses demonstrated that diabetes explained 12–14% of the risk for severe liver‐related outcomes after 10 and 20 years of follow‐up. Also, maternal diabetes increased the risk of liver‐related outcomes in the FINRISK (HR, 1.43; p = .044) and Whitehall II (HR, 2.04; p = .051) cohorts.
Conclusion
Approximately 12%–14% of severe liver‐related outcomes are attributable to diabetes at the population level. The association between maternal diabetes and liver disease might suggest a mitochondrial genetic mechanism.</description><identifier>ISSN: 1478-3223</identifier><identifier>EISSN: 1478-3231</identifier><identifier>DOI: 10.1111/liv.15296</identifier><identifier>PMID: 35574998</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>cirrhosis ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus - epidemiology ; Family medical history ; Fatty liver ; Fibrosis ; Genetics ; Health care ; Health risks ; hepatology ; Humans ; hyperglycaemia ; Liver ; Liver Cirrhosis ; Liver diseases ; Mitochondria ; Non-alcoholic Fatty Liver Disease - epidemiology ; Population ; Risk ; Risk Factors</subject><ispartof>Liver international, 2022-10, Vol.42 (10), p.2186-2194</ispartof><rights>2022 The Authors. published by John Wiley & Sons Ltd.</rights><rights>2022 The Authors. Liver International published by John Wiley & Sons Ltd.</rights><rights>2022. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3886-e47cd4b37c3d2f0a1b65149c73bbfe47c3479630943f31c175c35163ac092843</citedby><cites>FETCH-LOGICAL-c3886-e47cd4b37c3d2f0a1b65149c73bbfe47c3479630943f31c175c35163ac092843</cites><orcidid>0000-0002-0735-400X ; 0000-0002-0399-4931 ; 0000-0002-3833-0705</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fliv.15296$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fliv.15296$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35574998$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vuorinen, Miika</creatorcontrib><creatorcontrib>Männistö, Ville T.</creatorcontrib><creatorcontrib>Salomaa, Veikko</creatorcontrib><creatorcontrib>Britton, Annie</creatorcontrib><creatorcontrib>Jula, Antti</creatorcontrib><creatorcontrib>Männistö, Satu</creatorcontrib><creatorcontrib>Lundqvist, Annamari</creatorcontrib><creatorcontrib>Perola, Markus</creatorcontrib><creatorcontrib>Åberg, Fredrik</creatorcontrib><title>Attribution of diabetes to the development of severe liver disease in the general population</title><title>Liver international</title><addtitle>Liver Int</addtitle><description>Background and Aims
Diabetes is associated with advanced liver disease and predicts mortality regardless of the primary aetiology of the liver disease. Even a family history of diabetes has been linked to advanced liver fibrosis in non‐alcoholic fatty liver disease (NAFLD). However, the fraction of liver‐related outcomes in the general population that are attributable to diabetes remains unclear.
Methods
The population attributable fraction (PAF) of diabetes for liver disease as a time‐dependent exposure was estimated in the Finnish FINRISK study (n = 28 787) and the British Whitehall II study (n = 7855). We also assessed the predictive ability of a family history of diabetes for liver‐related outcomes. Incident diabetes data were from drug purchase/reimbursement and healthcare registries (FINRISK) or follow‐up examinations (Whitehall II). Incident severe liver outcomes were identified through linkage with national healthcare registries.
Results
Diabetes was associated with a two‐fold risk of liver‐related outcomes in both the FINRISK (HR, 1.92; p < .001) and Whitehall II (HR, 2.37; p < .001) cohorts, and this remained significant after adjusting for multiple confounders. PAF analyses demonstrated that diabetes explained 12–14% of the risk for severe liver‐related outcomes after 10 and 20 years of follow‐up. Also, maternal diabetes increased the risk of liver‐related outcomes in the FINRISK (HR, 1.43; p = .044) and Whitehall II (HR, 2.04; p = .051) cohorts.
Conclusion
Approximately 12%–14% of severe liver‐related outcomes are attributable to diabetes at the population level. The association between maternal diabetes and liver disease might suggest a mitochondrial genetic mechanism.</description><subject>cirrhosis</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Family medical history</subject><subject>Fatty liver</subject><subject>Fibrosis</subject><subject>Genetics</subject><subject>Health care</subject><subject>Health risks</subject><subject>hepatology</subject><subject>Humans</subject><subject>hyperglycaemia</subject><subject>Liver</subject><subject>Liver Cirrhosis</subject><subject>Liver diseases</subject><subject>Mitochondria</subject><subject>Non-alcoholic Fatty Liver Disease - epidemiology</subject><subject>Population</subject><subject>Risk</subject><subject>Risk Factors</subject><issn>1478-3223</issn><issn>1478-3231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp1kM9LwzAYhoMoTqcH_wEpeNHDtvxomuY4hj8GAy_DkxDS9Kt2dE1N2sn-e9Nt7iCYSxLeh-f7eBG6IXhMwplU5WZMOJXJCbogsUhHjDJyenxTNkCX3q8wJlJyco4GjHMRS5leoPdp27oy69rS1pEtorzUGbTgo9ZG7SdEOWygss0a6raPffg6iMJAcIH1oD1EZb1DP6AGp6uosU1X6V54hc4KXXm4PtxDtHx6XM5eRovX5_lsuhgZlqbJCGJh8jhjwrCcFliTLOEklkawLCv6kMVCJgzLmBWMGCK4YZwkTBssaRqzIbrfaxtnvzrwrVqX3kBV6Rps5xVNgg9zhkVA7_6gK9u5OiynqMBCUEl5GqiHPWWc9d5BoRpXrrXbKoJV37gKBahd44G9PRi7bA35kfytOACTPfBdVrD936QW87e98gelpYnC</recordid><startdate>202210</startdate><enddate>202210</enddate><creator>Vuorinen, Miika</creator><creator>Männistö, Ville T.</creator><creator>Salomaa, Veikko</creator><creator>Britton, Annie</creator><creator>Jula, Antti</creator><creator>Männistö, Satu</creator><creator>Lundqvist, Annamari</creator><creator>Perola, Markus</creator><creator>Åberg, Fredrik</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0735-400X</orcidid><orcidid>https://orcid.org/0000-0002-0399-4931</orcidid><orcidid>https://orcid.org/0000-0002-3833-0705</orcidid></search><sort><creationdate>202210</creationdate><title>Attribution of diabetes to the development of severe liver disease in the general population</title><author>Vuorinen, Miika ; Männistö, Ville T. ; Salomaa, Veikko ; Britton, Annie ; Jula, Antti ; Männistö, Satu ; Lundqvist, Annamari ; Perola, Markus ; Åberg, Fredrik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3886-e47cd4b37c3d2f0a1b65149c73bbfe47c3479630943f31c175c35163ac092843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>cirrhosis</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus - epidemiology</topic><topic>Family medical history</topic><topic>Fatty liver</topic><topic>Fibrosis</topic><topic>Genetics</topic><topic>Health care</topic><topic>Health risks</topic><topic>hepatology</topic><topic>Humans</topic><topic>hyperglycaemia</topic><topic>Liver</topic><topic>Liver Cirrhosis</topic><topic>Liver diseases</topic><topic>Mitochondria</topic><topic>Non-alcoholic Fatty Liver Disease - epidemiology</topic><topic>Population</topic><topic>Risk</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vuorinen, Miika</creatorcontrib><creatorcontrib>Männistö, Ville T.</creatorcontrib><creatorcontrib>Salomaa, Veikko</creatorcontrib><creatorcontrib>Britton, Annie</creatorcontrib><creatorcontrib>Jula, Antti</creatorcontrib><creatorcontrib>Männistö, Satu</creatorcontrib><creatorcontrib>Lundqvist, Annamari</creatorcontrib><creatorcontrib>Perola, Markus</creatorcontrib><creatorcontrib>Åberg, Fredrik</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Liver international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vuorinen, Miika</au><au>Männistö, Ville T.</au><au>Salomaa, Veikko</au><au>Britton, Annie</au><au>Jula, Antti</au><au>Männistö, Satu</au><au>Lundqvist, Annamari</au><au>Perola, Markus</au><au>Åberg, Fredrik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Attribution of diabetes to the development of severe liver disease in the general population</atitle><jtitle>Liver international</jtitle><addtitle>Liver Int</addtitle><date>2022-10</date><risdate>2022</risdate><volume>42</volume><issue>10</issue><spage>2186</spage><epage>2194</epage><pages>2186-2194</pages><issn>1478-3223</issn><eissn>1478-3231</eissn><abstract>Background and Aims
Diabetes is associated with advanced liver disease and predicts mortality regardless of the primary aetiology of the liver disease. Even a family history of diabetes has been linked to advanced liver fibrosis in non‐alcoholic fatty liver disease (NAFLD). However, the fraction of liver‐related outcomes in the general population that are attributable to diabetes remains unclear.
Methods
The population attributable fraction (PAF) of diabetes for liver disease as a time‐dependent exposure was estimated in the Finnish FINRISK study (n = 28 787) and the British Whitehall II study (n = 7855). We also assessed the predictive ability of a family history of diabetes for liver‐related outcomes. Incident diabetes data were from drug purchase/reimbursement and healthcare registries (FINRISK) or follow‐up examinations (Whitehall II). Incident severe liver outcomes were identified through linkage with national healthcare registries.
Results
Diabetes was associated with a two‐fold risk of liver‐related outcomes in both the FINRISK (HR, 1.92; p < .001) and Whitehall II (HR, 2.37; p < .001) cohorts, and this remained significant after adjusting for multiple confounders. PAF analyses demonstrated that diabetes explained 12–14% of the risk for severe liver‐related outcomes after 10 and 20 years of follow‐up. Also, maternal diabetes increased the risk of liver‐related outcomes in the FINRISK (HR, 1.43; p = .044) and Whitehall II (HR, 2.04; p = .051) cohorts.
Conclusion
Approximately 12%–14% of severe liver‐related outcomes are attributable to diabetes at the population level. The association between maternal diabetes and liver disease might suggest a mitochondrial genetic mechanism.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>35574998</pmid><doi>10.1111/liv.15296</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-0735-400X</orcidid><orcidid>https://orcid.org/0000-0002-0399-4931</orcidid><orcidid>https://orcid.org/0000-0002-3833-0705</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | cirrhosis Diabetes Diabetes mellitus Diabetes Mellitus - epidemiology Family medical history Fatty liver Fibrosis Genetics Health care Health risks hepatology Humans hyperglycaemia Liver Liver Cirrhosis Liver diseases Mitochondria Non-alcoholic Fatty Liver Disease - epidemiology Population Risk Risk Factors |
| title | Attribution of diabetes to the development of severe liver disease in the general population |
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