Follicular helper T cell signature of replicative exhaustion, apoptosis, and senescence in common variable immunodeficiency

Common variable immunodeficiency (CVID) is the most frequent primary antibody deficiency whereby follicular helper T (Tfh) cells fail to establish productive responses with B cells in germinal centers. Here, we analyzed the frequency, phenotype, transcriptome, and function of circulating Tfh (cTfh)...

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Veröffentlicht in:	European journal of immunology 2022-07, Vol.52 (7), p.1171-1189
Hauptverfasser:	Milardi, Giulia, Di Lorenzo, Biagio, Gerosa, Jolanda, Barzaghi, Federica, Di Matteo, Gigliola, Omrani, Maryam, Jofra, Tatiana, Merelli, Ivan, Barcella, Matteo, Filippini, Matteo, Conti, Anastasia, Ferrua, Francesca, Pozzo Giuffrida, Francesco, Dionisio, Francesca, Rovere‐Querini, Patrizia, Marktel, Sarah, Assanelli, Andrea, Piemontese, Simona, Brigida, Immacolata, Zoccolillo, Matteo, Cirillo, Emilia, Giardino, Giuliana, Danieli, Maria Giovanna, Specchia, Fernando, Pacillo, Lucia, Di Cesare, Silvia, Giancotta, Carmela, Romano, Francesca, Matarese, Alessandro, Chetta, Alfredo Antonio, Trimarchi, Matteo, Laurenzi, Andrea, De Pellegrin, Maurizio, Darin, Silvia, Montin, Davide, Marinoni, Maddalena, Dellepiane, Rosa Maria, Sordi, Valeria, Lougaris, Vassilios, Vacca, Angelo, Melzi, Raffaella, Nano, Rita, Azzari, Chiara, Bongiovanni, Lucia, Pignata, Claudio, Cancrini, Caterina, Plebani, Alessandro, Piemonti, Lorenzo, Petrovas, Constantinos, Di Micco, Raffaella, Ponzoni, Maurilio, Aiuti, Alessandro, Cicalese, Maria Pia, Fousteri, Georgia
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - genetics Autoimmunity B cells Common variable immunodeficiency Common Variable Immunodeficiency - genetics CXCL13 protein Deoxyribonucleic acid DNA DNA repair Genotype & phenotype Germinal centers Humans Immune aging Immune system Lymphocytes B Lymphocytes T Phenotypes Programmed Cell Death 1 Receptor - genetics Senescence T Follicular Helper Cells T-Lymphocytes, Helper-Inducer Telomeres Transcriptomes T‐cell exhaustion
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