MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis

Myelodysplastic syndrome (MDS) is a clonal disorder of hematopoietic stem cells (HSCs), characterized by ineffective hematopoiesis and frequent progression to leukemia. It has long remained unresolved how MDS cells, which are less proliferative, inhibit normal hematopoiesis and eventually dominate t...

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Veröffentlicht in:	Cell reports (Cambridge) 2022-05, Vol.39 (6), p.110805-110805, Article 110805
Hauptverfasser:	Hayashi, Yasutaka, Kawabata, Kimihito C, Tanaka, Yosuke, Uehara, Yasufumi, Mabuchi, Yo, Murakami, Koichi, Nishiyama, Akira, Kiryu, Shigeru, Yoshioka, Yusuke, Ota, Yasunori, Sugiyama, Tatsuki, Mikami, Keiko, Tamura, Moe, Fukushima, Tsuyoshi, Asada, Shuhei, Takeda, Reina, Kunisaki, Yuya, Fukuyama, Tomofusa, Yokoyama, Kazuaki, Uchida, Tomoyuki, Hagihara, Masao, Ohno, Nobuhiro, Usuki, Kensuke, Tojo, Arinobu, Katayama, Yoshio, Goyama, Susumu, Arai, Fumio, Tamura, Tomohiko, Nagasawa, Takashi, Ochiya, Takahiro, Inoue, Daichi, Kitamura, Toshio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Extracellular Vesicles - metabolism Hematopoiesis Hematopoietic Stem Cells - metabolism Mesenchymal Stem Cells - metabolism Mice Myelodysplastic Syndromes - metabolism
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